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I don't understand the last part of this question stem though... if the mother's TSH *increases* during pregnancy? Wouldn't this further increase her (and/or the fetus's) production of T4 and thus counteract the hypothyroidism?
@neonem no. Autoimmune hypothyroidism is a destruction of the thyroid gland, and a decrease in production of T3/T4.
An increase in TSH means that there is not enough T3/T4 to inhibit TRH, and so TSH is being released to stimulate the thyroid gland.
TSH, T3, T4 and thyroglobulin cannot cross the placental barrier.
@arezpr although those hormones can't cross, the autoantibodies from Hashimoto's can
The baby has its own TSH though
TSH comes from the pituitary, and act on the thyroid. Autoantibodies attack the thyroid, so TSH doesn't work.
I think there is no goiter because the baby's thyroid gland has not fully developed and these immunogloblulins from the mother could attack the thyroid gland leading to issues with it's development.
How do you know the gracile fasciculus is damage?!?!
which parte of the image its damage?, the pink? or black?
the pink park yes
i still don't see where the damage is lol! FML
i finally figured it out lol that was a slow moment i hope im not this slow on step yikes!
@hyperfukus I had the same problem at first, marked it and then came back. If you remember, in the spinal cord the white matter and gray matter are "reversed" compared to the brain. That said, if the butterfly shaped region (ie, the gray matter) is colored (in this case) lilac and the rest (ie, white matter) is blackish, the only thing that is actually abnormal, is the region where the dorsal columns are, because it stains just like the normal gray matter. After that, you have to think about which fasciculus is damaged, the gracilis or the cuneatus. The gracilis is medial while the cuneatus is lateral (picture someone with glued legs and open arms). Hope this helped
Gracilus Fasciculus = Graceful legs
Check out FA2020 pg 508
myelin= black --> color of the normal white matter
no myelin= pink --> color of the normal gray matter and the damaged area
Dorsal columns= vibration, proprioception, pressure fine touch
F. graciLis= Lower body
F. cUtaneous= Upper body