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 +1  (nbme21#49)

The N-terminus is where you have signal peptides which define the target of the proteins (think of them as postal code). Typically, proteins are in the cytoplasm after they are made, but since the have tags at n-terminus, they go to different targets like this case ER. Now, if the protein is retained in the cytoplasm, this means the mutation disabled the tag (no postal code). Hence, it is kept in the cytoplasm.

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