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Welcome to brotherimodu’s page.
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Anki Card I made: Vagina = {{c1::Stratified squamous}} Cervix = {{c1::Stratified squamous --> simple columnar (endocervix)}} Uterus = {{c2::simple columnar}} Fallopian tubes = {{c2::simple columnar}} Ovaries = {{c3::simple cuboidal}}

brotherimodu  For some reason I don't trust you +9  
focus  ^^^ haahahaha. Thankfully the patients aren't seeing these usernames +  


submitted by gh889(94),
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Rnirgreef to sRINT dna RIsNTN sa smtainya of temtrtean

n:aytsaiM ezfranvie N)TNI(R, reinootfv ,N)RTI( dna triitnaecibem )(ITRN

ususmle  I guess he is asking about integrate,,,,, where his should be integrated into host dna to get replicated .. triple therapy includes. 2drugs NRTIs and other one is integrate +  
whoissaad  @ususmle NRTIs would still inhibit DNA synthesis since they mess with the reverse transcriptase which is needed to make viral DNA. +2  
thotcandy  @ususmle HIV triple therapy is 2 NRTIs/NNRTIs + 1 protease inhibitor. Plus, if her CD4+ cunt is already 60/mm, that shit is well integrated in her CD4 cells already, right? +1  
brotherimodu  I was confused because isn't HIV an RNA virus? +  
focus  @brotherimodu yes and therefore it uses a reverse transcriptase +1  


submitted by nwinkelmann(265),
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o,S for soem ensaor, unrtmrstrsineetoa is soienhtmg 'evI SAWLAY dlresgugt it.wh.. lbypaobr abeucse I ns'atw thtuga it lelw os enrev reylal eadenrl ,it jtsu neaelrd ugeonh orf tewahrev eamx. I sjut udfon itsh oob hgthoru CBNI nad tsi S!TCAIATFN t'sI orfm 0021 so imhgt eb ,lod but ti asw e.rgat uoY nca ahrsce uhhrotg eth okob adn ifdn het cpa.esrth I eyprtt umhc sutj twne uhtghro lla of teh tetnoumaerstinrr erc.tpha .Kthon:n1io/cvbwm./i79pwN/nsol/wt0/.hkbsg.9B

My niam e:wkayt-laaase aGutmt = ojrma xyoeriattc rretmiotnen.ruats owT stpey fo rct po)es:r1e tr,biceaptmoo stom fo hiwch era arcynpepist iG ihhcw slaed to scadedeer MDNA opetrrce tiivycat dan rkis fo ooytitxxieitic,c or yocistapntsp qG csrroepte htta leda to sceraine ,+aN ,K+ dna sededreca mtglaeaut usacse zidlioratepona nad decniraes +gM+ sindmtaeclpe nda DMAN perocter atctyvii and rski fo oicetxx,oitytic adn ) 2 rntiooopic achensnl lcudngnii MDNA adn A/MieAnkaPta ,nnhalecs ihhwc all olawl fenincpsoci citona ixlu,nf tbu ylno DNMA alsolw a+C+ nlxfui a(dn ynlo in a etglova tdendepen annrme freat iufsceitnf oolnrapiiazdte has sdldeacip teh ntioirbih +g+M oni ni het .aen)lhnc

BAGA adn ngilecy = iiinobyhrt sutmrent.erriaston )1 BG-AAA dna GAABC- = inioocrtpo schlanne that lade ot flxeu of ,l-C and etpdsei hits ugcsnia r,ineaalopodzti the rneoun tlsil systa olweb esnirgt .anitotpel AABG-A dniigbn tise rfo tirarbstuab,e stid,reos G,AAB dan inorcioptx = isneid rpoe fo ahcneln. AAAGB- gbnindi iets fo eeiaipnzosbzden = tdsoieu of epro of anchl.ne 2) elGncyi nhnelca si a ryve imsrlai l-C lxfue nhn.laec )3 AGBAB- si a roactetomipb achnenl thta ittseaavc Gi gnalied to rdedacese cAMP hwcih atacesitv exlfuf +K hsneacln dan biiisnht Ca++ xlinuf nlchanes aelngid ot arneoyorpi.iphzlat

ncoBiieg eanims = nhamleocacsite dnpaoemi t(dicinoonroa of oydb on,mvmtee ewr,adr mao,ntiotiv ereencorit,fmn) iponnriperehen plees(, ef,wnueslask neto,tatni difneeg ,braeivoh npirehepnie tlewso( ancttocrenion ni ,)NSC lsup rsoeinnot es,e(lp sae,nefwlksu dsesp,oirne yxeatin, naea)su adn itnhmaies a(r,alosu nitt,eoant eaygrl,l tisues ,eagmad dna yma nieuelnfc odlbo arbin f)ol.w Ouo,iyblsv lla of htis is in oditaind ot aiencdegrr nnsoriosesntuarmi dna t,ihglf ifr,tgh nda gtifh pesn.orse

TPA and thore prniseu = iatrytxeco sasnirmons,ti edace-rsleo tihw theor ecllomulela-sm msrstn.reortietnua oseAdenin 'nist icclaslalys riondeescd a stnatrirutorneem bcaesue ti n'tsi aelseo/sdrrdeet ni +a+C tdeednnpe a,enmrn utb idvered ofmr TPA eobrfe vihgna an icyaotxret ol.tptneai

ylAlcthoencei = jraom nertuotmsratenir vdiovenl in oirnsomsnsiuenart iva aunmisrc adn niincctoi s.roeectpr

deitPpe srertesnormttnuia = mcmnoyol darelees as prtpoipeed lraerg sourscerrp htta rea vcadele by scfipeic ensezmy ttha ewre ni het eams ittrtoernanrmuse cesielv uonp lerae.se Feiv ptsey = rb/uitgan p,tsipdee iopiod spied,tpe utypraiit edit,pps yahpolamcthi sielgnare rmen,osho and ethso not ifeaci.ssdl sxmleaEp = urceorrps thta gseiv rsei ot uesctnbsa P icp(hsou,mapp eoexcont,r adn GIT nad sledaree rofm lmsal amdreeit SNP C birfes tath tnaisrtm naip nda epteraruemt ramn,tiooinf rofwpleu ehntyeisovp, nidiihebt yb iidoop ptpid,)ees iknironneu ,A enpurodieept K, nad duerenetoipp gmaa,m adn ioiodp steipedp iidugnlnc tapnl lisdaolak lik(e ,ehroi)pmn tnetyschi oiidop ,sevdvirtiae and nnh,ersdpoi n,nrshdpoyi nda elepaksnnhi. In rgaleen opiiod tesepdip rae sraesdspten i(e.. anlesaagi h,imecas)mn vovdlein in cexmlpo rhsoabive ealxu(s a,noraitctt ggssmveiasuserebi/vis )hrsvbe,oai dna ilmatpdiec (oghuht otn fni)diietve in iphstiycrca sdsor.erdi

Ovallre, reusnomtstiernrat = peyt sety:p elsu-camleomll issmatnrtter and oenpsitrd,uepe erweh ocslllmmau-esel atssmtretirn rea fesrta and itedmea irdpa iysntacp ssiisnmontra ei(.. narnogde NSS hff/f/rlhtgggiitith qkuic eenr)pss,o heewr as ridsptenuoeep ng(loa tihw coilibog iasnem and msoe amsll mlloeecu serrttamni)ts rae soewlr nad tiamdee rlagdau, rldopnoeg rrsmnnioneaoss.iut

meoS p:csteuir kpotihentdow//somtedfphn/twpiulanoe:anrwvvemiasb.isutr_drr.k/ecumth_tue_/rep.e, 3ogegn1uea/Aa1i-e.iG0a31-sh12/Br8dr6taw/sif1e26horbna/gd-o-pas7r-sfaett/ip-2BtebrbR6l-0rAe/prlf-8dp60c4c.mb5t0owrTr3hl44/0gssnaefgu3etPd9ewuiepcc:i, dan hafa--b2aelwae01e/=nrig&ds2-ef_e-ea;h/-xbbntxw4bgit:01g.r-U/gh3a98e7/-dladftu5/ditsp.g.ed#rli3l6a5ocw6bsfw1mt-/=pne1

sweetmed  This is amazing. thank you +  
sweetmed  This is amazing. thank you +  
paulkarr  Woah... +  
brotherimodu  Short video someone posted from NBME-21 answers: https://www.youtube.com/watch?v=4-DuvwoH2zQ +1  
dorischang  Didn't finish reading this, but it looks awesome +  


In a pancreatic B cell glucose enters via GLUT 2 and enters glycolysis. This causes the increased concentration of ATP in the cell causes the closure of ATP sensitive K+ channels. When this happens the cells becomes depolarized allowing Voltage gated Ca2+ channels to be open. The Ca2+ allows for exocytosis of insulin into the blood vessel.

Hence the answer here... Fusion of an intracellular vesicle with the plasma membrane.

pg 324 FA 2019 has the image

brotherimodu  Woah. Who knew the body was so complicated? +  


submitted by soscrying(8),

at my uni, we learnt that at lower GFR, loop diuretics still work. That's why you should use them in renal failure. Thiazides would not work with a GFR of <30.

qball  Dang, you actually learned something at your school? Lucky. +9  
lowyield  At our med school they teach us that Thiazide anti-HTN function is primarily from it's direct effects on vasculature rather than it's diuretic effects. Somehow directly affects the vasculature which is not well understood but this is linked to why Thiazides have greater efficacy in African American Populations. That's kinda why i figured it wouldn't be the best diuretic in this case. +  
brotherimodu  lowyield but interesting +  


submitted by sympathetikey(1029),
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Berett tpiceur - tat-cea/wb8/Bvupw1atecdjo2/mh:Nl1sw/els.c/ancwpotu-.tg/sor.0/0elphnrp

yb_26  @at0xibolic, I think you won this competition on finding better picture lol thanks +5  
drschmoctor  Those may be better, but this is the BEST. http://bitly.com/98K8eH +5  
brotherimodu  god damnit +  
jesusisking  Not again (´∀`) +  


submitted by beeip(118),
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aCn nyaoen anelpix athw eeyht'r gnitget at h?ree woH nca haocbetnhle eb tddecniia and ccdtirnodea?tian

sniperx3  I think it's because Bethanechol acts on M3 receptors which can treat her urinary problems but it might exacerbate her asthma symptoms since there are M3 receptors on the lungs. +32  
suckitnbme  I definitely had to read this question multiple times to understand it. +2  
brotherimodu  I read it like 6 times and gave up +1  


submitted by youssefa(111),
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I nmae hyw wluod a tlesecti runt narduo tlesfi wneh eosoesmn' ilgsee.np Tish caytllpyi ocrscu aeftr potrss/ lccyibe dirnig tc..e

brotherimodu  People can move in their sleep? +1  


submitted by usmleuser007(337),
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iaernoueogtrNnree ni het ipralpreeh rneusov yetsms SN()P ocsurc to a nfatsiciign 6]ee]g[ed[.5r Aerft na ujnyir to teh xn,ao palrepihre ennosru viaeatct a rievtya fo igsglnnia pthwysaa chwih trnu on horgo-rpwt enesg, dagilne to iteromnarfo of a alnufotnci tgrowh econ nda ne.aiernegtro heT gworth of heest nsxao is saol vnoegder yb miahcotetcc cfasort edetrsce form hnnacwS lls.ce uyrjIn ot eht ehreaplirp eusrovn etysms imeialmdtey eciitls eth trniimaog fo aotc,esphgy nnwhacS lles,c nda arsmphgaeoc to eth iolnse itse in drore to rleac aayw bderis cuhs sa agdamde isuets wichh is ytobnriihi ot earnngoet.rei henW a rneev nxoa si ere,vdes het ned llist dcehtaat ot het elcl ydob si ealeldb het ramilxop ge,nmste ihelw eht rtohe dne si acleld the daitsl entemsg. trfAe ,juniry eth paroixlm end lselsw nda reeesnixecp some grreeatord iateeendo,ngr btu econ eth eirdbs si de,alerc it sgibne ot stpuor noasx dan hte nrcsepee fo hwtogr cenos nca eb eeedctt.d heT ilmrxaop anxos are bela ot weorrg as lnog sa the lcle ydbo si ntcati, adn yhte have adme ntccota twhi hte Snwhanc lcsle in het unieraoldne cnaelnh or .teub manuH onax htowrg trsae anc reahc 2 /ymamd in lamsl vsrnee dan 5 d/aymm in lgrea .sr4v[en]e eTh ladtsi g,ntseme ,horeevw pesnecreixe lainlraeW aegnndeetior nwtiih suohr of het uy;irnj eht anxso and myleni ,egnetaeerd btu teh enmduieounr erinsma. In the etral saegts fo ngonerrtieae eth grneinaim iurnlaeoedn utbe ecitrsd nxoa gtrowh kacb to eht octerrc aret.gst nDurig Waaeinllr ,antrneeoiegd hnwacnS sclle ogwr in drereod onmsulc gnloa hte oineanrdlue ubte, trceinga a band of egünnrB o()bB that tcrtoesp dna erpssreev hte uralneoedin nnlchea. lA,os aecmogashpr adn nwnchaS slelc leeesar pethoocurinr fcastro htta neencah .whgt-orre

()iiwk

brotherimodu  That describes Schwann cells' involvement with neuroregeneration, but I don't see how it answers the question "Which cell is blocking reinnervation" +  


submitted by cr(3),
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yhw otn .?C tIs´ ton supeso atht ti evpoimr eht tcifyeitev fo iunn?sil

yb_26  thiazolidinediones (pioglitazone) increase insulin sensitivity (in muscles and liver) through activation of peroxisome proliferator-activated receptor-gamma (PPAR) I think they are asking about primarily mechanism of action, that's why it is E +  
cienfuegos  UW explanation regarding the genes upregulated 1. GLUT4: insulin responsive on adipocytes/skeletal increases G uptake 2. adiponectin: cytokine secreted by adipocytes increases # of insulin responsive adipocytes and stims FA oxidation 3. PPAR family also plays significant role in pathogenesis of metabolic syndrome +1  
poisonivy  Also, I think the word uptake shouldn't be right when speaking about insulin, it does increase insulin sensitivity and therefore glucose uptake +5  
brotherimodu  @poisonivy That's why I didn't choose C and went with E since it was more specific +  


submitted by hungrybox(831),
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nehw fidf ilsegn dantsr aeprir ssniaehcmm rea ed:us

  • irpare lewny seydhnzsiet :ndtras timasmch piarer Lnyhc( )smrnydoe
  • earpir rideymipni eisdrm asceud by dta VU esx:ouper odlueinect coeixsni prarie eX(mrorade ngis)mueptom
  • erapir t/secunptoaxioosn elaniot:rta bsea xisiceno peairr
meningitis  Brca: recombinant repair +  
brotherimodu  P.40 FA2019 lists the different DNA repair mechanisms +2  
teepot123  fa '19 pg 382/3 +  


am i the only one who chose mesothelioma? didnt that look like a pleural plaque posteriorly to anyone?

brotherimodu  That's what I thought too. +  


submitted by hayayah(1000),
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Patotisrtis is aczderarcehit by a,ryidus creequnyf, reyg,ucn lwo back .niap aW,mr e,tdnre eerdganl r.pstoeta

tceAu tbleacair tniarsspott—ii eldro emn mtos nomcmo ricteubma is E. .lioc

ergogenic22  In young men it could be chlamydia but the question stem makes no mention of sexual activity, so it is e. coli +11  
charcot_bouchard  First this guy isnt older! He may incite Daddy issue but not older. At this age people tend to be more monogamous so E Coli the more likely answer. But again cont NBME 20 trend this one was pretty vague too. +1  
monkey  They classify at 35 year old (<35 = Chlamydia or Neisseria and > 35 = E.coli) +3  
mbourne  I put Pseudomonas, as that is a cause of prostatitis in older men, but it is less common than E. coli. Just keep that in mind, if E. coli wasn't an answer choice, the answer should have been Pseudomonas. If he was a younger male, then Chlamydia would have been acceptable. +3  
brotherimodu  @mbourne I think Pseudomonas is the more common etiology for acute prostatitis in the elderly (>65ish for exams), whereas E.Coli is the more common etiology in adults 35-64yo +