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Contributor score: 5

 +0  (nbme21#45)

For this one you just had to know the glycolysis pathway. Stem told you 2,3-BPG is elevated, which is upstream of pyruvate kinase.

 +0  (nbme21#11)

Histology showed coagulative necrosis (preserved architecture of myocardial fibers) with neutrophil infiltration which hinted that the MI was within 24 hours. Most likely cause of death within first 24 hours of MI is arrhythmia. Myocardial rupture would also be visible on gross appearance of the heart, which they described in the stem.

 +0  (nbme21#45)

This one was tricky but I think you could’ve done this one without knowledge of NMDA receptors. Stem told you that glutamate activates both non-NMDA and NMDA receptors but it activated only non-NMDA receptors in the early phase. That means NMDA receptors activate after non-NMDA receptors. That means something was delaying NMDA receptor activating and the only answer that made sense as the Mg inhibiting NMDA at resting potential. Once the cell is depolarized by non-NMDA receptors, NMDA receptors can be activated.

 +0  (nbme21#31)

Hypo/hyperthyroidism is diagnosed with TSH w/ reflex to T4 (this just tells the lab if TSH is normal don’t check T4 but if TSH is abnormal, check T4 too). TSH wasn’t an option so T4 is the best answer.

 +0  (nbme21#15)

Proccess of elimination for this one. Two you can eliminate immediately just from looking at the biochemical pathway chart. The other two required knowledge that eumelanin is more protective than pheomelanin (this is why redheads burn more easily). Because pheomelanin is less protective, there would be more not less ROS from sunlight.

 +0  (nbme21#3)

Capsular polysaccharide vaccines are often conjugated to proteins to improve immunogenicity. Flagellin is the only answer choice that's a protein.

 +3  (nbme21#25)

She’s intaking 450 mOsm per day so she needs to excrete 450 mOsm per day to maintain equilibrium. You can’t just excrete mOsm’s by themselves -- they have to be dissolved in some amount of water.

Let’s say you excrete 450 mOsm with 500 mL of water -- that means your kidneys are concentrating urine to:

450 mOsm ÷ 500 mL = 900 mOsm/L

But the maximum this lady’s kidneys can concentrate urine to is 450 mOsm/L, so she has to excrete more water to get it that dilute. That amount of water is 1 L, because 450 mOsm/1 L = 450 mOsm/L.

Now there’s nothing stopping her from excreting the 450 mOsms in an even more dilute urine -- for example if she drank an extra L of water one day, the kidneys could get rid of that extra L with the same amount of 450 mOsm by diluting the urine to 450 mOsm ÷ 2 L = 225 mOsm/L. But the question asks for the minimum amount of water -- which is 1 L by the kidneys (+ 1 L from the other stuff for a total of 2 L).

 +2  (nbme21#6)

Recurrent kidney stones should include hyperparathyroidism on your differential, couple that with gastrinoma and you’re looking at MEN 1. Lipomas are also associated with MEN 1.