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 +0  (nbme24#42)

Why would you give GMCSF to someone with AML?? Isn't the whole goal of treatment to knock out the granulocytes? I feel like giving someone GMCSF after they were JUST treated for AML is asking for a relapse but what the hell do I know.

drdoom  The problem in AML (acute myeloid leukemia) is that precursor cells “get stuck” on their way to becoming (mature) granulocytes. Giving GM–CSF “pushes” them toward a more differentiated state and, because they divide as they mature, the cells become vulnerable to drugs that disrupt cell division (replication): “Granulocyte–macrophage colony-stimulating factor (GM–CSF) can stimulate proliferation of leukemic blasts and sensitize these cells to the cytotoxic effects of S-phase–specific drugs.” https://www.nature.com/articles/2402368




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