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 +3  (nbme24#6)

The 3-cm ectatic aorta means she has an abdominal aortic aneurysm. Generally, they tend to occur below the renal branches so I went with the two closest branches- SMA (slightly above renal) and IMA (below renal). Also, splenic flexure is a common watershed area supplied by SMA and IMA so involvement of both can cause her symptoms

 +6  (nbme24#12)

Vd = amount of drug in body / plasma drug concentration.

Amount of drug in body = 80mg

Plasma drug concentration = 4 micrograms/mL = 4mg/L

Vd = 80mg/(4mg/L) = 20L

Distribution half-life is 3 minutes so after 30 min we can assume the drug is maximally distributed. Elimination half-life is 24 hours so we can assume a neglible amount of drug lost

 +2  (nbme24#32)

Histamine plays a major role in the cardinal signs of inflammation. It helps mediate vasodilation and vascular permeability (via endothelial cell contraction). These two functions are already contrary to A, B, C, and D. By increasing fluid in the interstitial space, you can reason that there will be increased lymph flow.

youssefa  If more transudates are leaking into the interstitium wont this dilute the interstitial proteins and cause a decrease in oncotic pressure and increase in interstitial hydrostatic pressure?
titanesxvi  @youssefa I think because it is an exudate from increased permeability of venules, the oncotic pressure in the interstitium is not going to decrease
thotcandy  @youssefa transudate is like pulmonary edema due to CHF, no proteins, just fluid congestion and leaking out. That would decrease interstitial oncotic pressure because it has very little protein. Exudate due to inflammation/histamine has a high amount of protein (due to inc permeability) so the IOP doesn't change.

Subcomments ...

submitted by yotsubato(520),

Why is the patient not in pain. I wouldnt expect Incarcerated hernia to present with zero pain, but 1 week of constipation and swelling.

yotsubato  Incarcerated hernia. If the contents of the hernia become trapped in the weak point in the abdominal wall, it can obstruct the bowel, leading to severe pain, nausea, vomiting, and the inability to have a bowel movement or pass gas. Like really? Why is he not in pain? +1  
medschul  I thought that inguinal hernias were reducible? +  
fahmed14  could be a femoral hernia as they are more likely to cause incarceration. They do, however, present more often in females. (FA 2019- 364) +1  
wowo  incarcerated, not strangulated, thus no pain as there's no serious tissue damage/ischemia. Incarcerated hernias may progress to strangulated in which case he would have pain Under section, "complications" https://www.amboss.com/us/knowledge/Inguinal_hernia +3  

mousie  http://www.sparknotes.com/biology/cellreproduction/cellcycle/section3/page/2/ +3  
fahmed14  Cyclins help regulate cell cycle phases. They help with checkpoints before progression to the next phase of a cell cycle. Therefore the checkpoint before mitosis would be in G2 and probably where mitotic specific cyclins are synthesized +6  
artist90  https://en.wikipedia.org/wiki/Cyclin . 4 types of Cyclins and when they rise and fall. +1