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School:

(nbme22#41)

`Maintenance dose = (Css * CL * t) / F`

... where `t` is elapsed time between doses (not relevant here since it’s continuous infusion) and `F` is bioavailability (which is 100% or 1.0 here because it’s given IV).

`(Css * Vd) / F`

... where `Vd` is volume of distribution.

yotsubato  So do we just have to memorize this...
gh889  yep
drschmoctor  @yotsubato Not necessarily. I can't remember a formula to save my life. The Css is the amount you want in the blood. The clearance is the fraction removed per unit time. Since we want to maintain a steady state, we only need to replace what is removed. Thus, maintenance dose = amount present * fraction removed.

(nbme22#33)

Like others have said, I think sublimation would have been better, but displacement from first aid says that it is, “redirection of emotions or impulses to a neutral person or object” so she’s kicking her family by kicking the bag.

submitted by mcl(385),

Pronator teres and quadratus are both supplied by median nerve (C5/C6/C7/C8/T1, so that's not super helpful.) Extension of the forearm is radial nerve (also C5-T1, also not helpful). This does tell us is it can't be isolated median or radial. Triceps tendon reflex is C7/C8, which narrows it down to these two.

Can anyone explain why it's C7 over C8?

joha961  Same question. How could you determine between the specific nerve roots (C7 vs. C8)? +1
mcl  Someone I was talking to (and post below) was saying that first aid mentions triceps is C7, so that's what should've been the big thing for us. +1

submitted by pipter(8),

Does anyone have any specific idea on the mechanism of the p53 mutation question regarding the TATA box (the one with the single amino acid conversion and the different hydrogen bonding)?

I chose the decreased binding of RNA polymerase on the TATA sequence of genes that inhibit cell division based solely on the fact that p53 is a tumor suppressor (aka mutated p53->less inhibition of division->multiple divisions).

joha961  From a random paper I found, “Arguably p53’s most important function is to act as a transcription factor that directly regulates perhaps several hundred of the cell’s RNA polymerase II (RNAP II)-transcribed genes.” So normally it increases RNA pol binding; a mutation would decrease it. +1
estsosa  The TATA box is part of the promoter region site where RNA polymerase II and other transcription factors bind to DNA. A defect would therefore decrease binding of RNA polymerase. +5
mnemonia  Also you can reason it out (I got this wrong because you have to be really meticulous) since we know that loss of p53 = cancer. Cancer = want more cell division = don’t want inhibitory gene = less transcription of said gene. +