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Welcome to jsmoov’s page.
Contributor score: 13


Comments ...

 +1  (nbme21#19)

This patient has ACQUIRED ANGIOEDEMA, which is different from Hereditary. In Hereditary you do NOT present with urticaria as mentioned by some previous comments.

https://aacijournal.biomedcentral.com/articles/10.1186/1710-1492-6-14

Acquired angioedema (AAE) is characterized by acquired deficiency of C1 inhibitor (C1-INH), hyperactivation of the classical pathway of human complement and angioedema symptoms mediated by bradykinin released by inappropriate activation of the contact-kinin system.


 +0  (nbme22#4)

The main differential here is RA vs SLE. They have many overlapping signs and symptoms (including pleuritis and pericarditis - as well as scleritis), but the key differentiating factor is that RA typically doesn't involve KIDNEY damage.

Lupus, however, is well known for causing DPGN.


 +1  (nbme13#19)

Branchial cleft cysts typically occur due to failure of the 2nd branchial cleft to obliterate resulting in a persistent cervical sinus. Branchial cleft cysts will not move with swallowing and classically occur anterior to the sternocleidomastoid muscle


 +2  (nbme13#21)

Positive staining for synaptophysin and chromogranin are immediate buzzwords for neuroendocrine tumors. Paragangliomas are the only type listed here.

Others would be small cell carcinoma of lung, carcinoid tumor, gastrinomas/insulinomas/etc, pheos, medullary carcinoma of thyroid.


 +0  (nbme13#8)

Midline mass that moves with swallowing = thyroglossal duct cyst


 +6  (nbme13#2)

This baby has abetalipoproteinemia. ("without Beta apolipoproteins"). Thus they will lack B-48 and B-100 and have absent levels of chylomicrons, VLDL, and LDL. Infants present with severe fat malabsorption and deficiencies of all fat soluble vitamins (ADEK). Lack of vitamin A renders them vulnerable to Retinitis pigmentosa and lack of VitE leads to spinocerebellar degeneration.


 +2  (nbme13#31)

Halides are the elements in the 2nd the last column of the periodic table (F, Cl, Br, I, etc). Defective MPO prevents conversion of H2O2 into HOCl (a hydroxy-halide) which is aka bleach and the most powerful antimicrobial our phagocytes can synthesize


 +1  (nbme13#30)

Klebsiella has a capsule and is spread through person-to-person contact (e.g. from patient to patient via the contaminated hands of healthcare personnel). "The bacteria are not spread through the air"





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