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Welcome to jsmoov’s page.
Contributor score: 13

Comments ...

 +1  (nbme21#19)

This patient has ACQUIRED ANGIOEDEMA, which is different from Hereditary. In Hereditary you do NOT present with urticaria as mentioned by some previous comments.

Acquired angioedema (AAE) is characterized by acquired deficiency of C1 inhibitor (C1-INH), hyperactivation of the classical pathway of human complement and angioedema symptoms mediated by bradykinin released by inappropriate activation of the contact-kinin system.

 +0  (nbme22#4)

The main differential here is RA vs SLE. They have many overlapping signs and symptoms (including pleuritis and pericarditis - as well as scleritis), but the key differentiating factor is that RA typically doesn't involve KIDNEY damage.

Lupus, however, is well known for causing DPGN.

 +1  (nbme13#19)

Branchial cleft cysts typically occur due to failure of the 2nd branchial cleft to obliterate resulting in a persistent cervical sinus. Branchial cleft cysts will not move with swallowing and classically occur anterior to the sternocleidomastoid muscle

 +2  (nbme13#21)

Positive staining for synaptophysin and chromogranin are immediate buzzwords for neuroendocrine tumors. Paragangliomas are the only type listed here.

Others would be small cell carcinoma of lung, carcinoid tumor, gastrinomas/insulinomas/etc, pheos, medullary carcinoma of thyroid.

 +0  (nbme13#8)

Midline mass that moves with swallowing = thyroglossal duct cyst

 +6  (nbme13#2)

This baby has abetalipoproteinemia. ("without Beta apolipoproteins"). Thus they will lack B-48 and B-100 and have absent levels of chylomicrons, VLDL, and LDL. Infants present with severe fat malabsorption and deficiencies of all fat soluble vitamins (ADEK). Lack of vitamin A renders them vulnerable to Retinitis pigmentosa and lack of VitE leads to spinocerebellar degeneration.

 +2  (nbme13#31)

Halides are the elements in the 2nd the last column of the periodic table (F, Cl, Br, I, etc). Defective MPO prevents conversion of H2O2 into HOCl (a hydroxy-halide) which is aka bleach and the most powerful antimicrobial our phagocytes can synthesize

 +1  (nbme13#30)

Klebsiella has a capsule and is spread through person-to-person contact (e.g. from patient to patient via the contaminated hands of healthcare personnel). "The bacteria are not spread through the air"

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