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Alcohol withdrawal sx (p. 554 FA 2018)
Time from last drink:
3–36 hr: tremors, insomnia, GI upset,
diaphoresis, mild agitation
6–48 hr: withdrawal seizures
12–48 hr: alcoholic hallucinosis (usually visual) 48–96 hr: delirium tremens (DTs)
FA 2019 p. 353: Most common cause of gastric outlet obstruction in infants (1:600). Palpable olive-shaped mass in epigastric region, visible peristaltic waves, and nonbilious projectile vomiting at ∼ 2–6 weeks old. More common in firstborn males; associated with exposure to macrolides. Results in hypokalemic hypochloremic metabolic alkalosis (2° to vomiting of gastric acid and subsequent volume contraction). Ultrasound shows thickened and lengthened pylorus. Treatment is surgical incision (pyloromyotomy).
EBV also targets B lymphocytes
Mitochondrial myopathies—rare disorders; often present with myopathy, lactic acidosis, and CNS disease, eg, MELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes). 2° to failure in oxidative phosphorylation. Muscle biopsy often shows “ragged red fibers” (due to accumulation of diseased mitochondria).