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Comments ...

 +0  (nbme18#21)

uptodate says it can cause only osteolytic lesions too, and because it says "most likely" and breast cancer is the most common cancer in women, it is breast ...


 +4  (nbme18#34)

the radiation therapy caused fibrosis and the myofibroblasts "contract" during fibrosis, causing the closure of airways and thus atelectasis


 +1  (nbme18#27)

chronic bronchitis causes squamous metaplasia of the pseudostratified columnar epithelium in the bronchi and bronchioles

---- these columnar epithelium normally contribute to the mucociliary clearance and smoking also damages this clearance, so can get the clue from that too

donttrustmyanswers  Pseudostratified columnar epithelium is only present in the bronchi. The bronchioles have simple ciliated columnar epithelium.




Subcomments ...

submitted by lamhtu(67),

Stem should maybe say some lesions are lytic and some are sclerotic. Breast mets to bone is mixed type according to FA? If you go off the mets being purely lytic, one could think thyroid carcinoma is the correct primary tumor.

lae  thats also what I thought +1  
pg32  Yeah I didn't pick breast for the same reason. Then I didn't pick thyroid because I doubt serologic studies would be normal in thyroid cancer (if you check T3/T4 and TSH). So I went with avascular necrosis -_- +  
lynn  in the FA index, the only things listed under lytic bone lesions are adult T cell lymphoma, langerhan histiocytosis, and multiple myeloma. Obviously there's more than that but those might be the main ones we need to know. You could also say that a giant cell tumor is also technically lytic, considering they describe it as "osteoclastoma." Idk. I thyroid but looking at FA, none of the thyroid carcinomas describe metastatic lytic lesions. Medullary carcinoma might be the one to confuse you, but it secretes calcitonin which inhibits osteoclasts, so it shouldn't cause resorp or lytic lesions. Right?? +  
prp5c  just a different view - I was between avascular necrosis and metastatic carcinoma, but ended up going with metastatic carcinoma because I figured avascular necrosis of the lumbar and thoracic region would be hard since you'd have the artery of Adamkiewicz as a dual supply to the vertebrae? +  


submitted by ergogenic22(178),

I believe that the question is suggesting the patient has a methanol overdose.

First Aid 2018 page 72: "FOMEpizole—inhibits alcohol dehydrogenase and is an antidote For Overdoses of Methanol or Ethylene glycol."

The reason I am unsure is that wikipedia states most paint thinners are ketones or hydrocarbons

lae  that's correct, I don't know about what the thinner has but the clinics is methanol toxicity for sure +  


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