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Welcome to omerta’s page.
Contributor score: 33

Comments ...

 +11  (nbme22#9)
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I ohugtth tish mgiae asw .fleplhu


Subcomments ...

submitted by usmleuser007(366),
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omSoeen rcea ot peinalx yhw mi[te to atstasdeyte- tnoeotcnrna]ci si otn hte crercot narw?es

omerta  In pharmacokinetics, steady state refers to the situation where the overall intake of a drug is fairly in dynamic equilibrium with its elimination. In practice, it is generally considered that steady state is reached when a time of 4 to 5 times the half-life for a drug after regular dosing is started. The time to reach steady state is defined by the elimination half-life of the drug. So in a patient with renal dysfunction, the plasma half-life is going to be prolonged and the time to reach steady state will increase proportionally. +11  
belleng  loading dose is independent of the concentration of the drug in the plasma and the dose frequency...this is why you give a patient who is seizing a huge dose of anti-seizure meds in order to reach a theraputic range on the first dose despite the high risk of toxicity and side effects...primary objective when seizing is stoping the seizure so you want to increase the dose response curve with a massive load +  
belleng  loading dose is independent of DOSE (should have said dose, not concentration in plasma) & FREQUENCY +  

submitted by jooceman739(26),
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ehT yaipchsni dsia eht boy si ulnyelki ot edplove yna hetor ,snampsoel so eh ntde'so have het eeritnidh bR atu.imtno

In siht ,csea eh has teh capirods nilotarbs.mteoa irdSaocp lrabsateointom eesrurqi otw aoicmts mnsuttiao fo Rb in hte msea letnrai cl.el

tuJs sa a dise enot: hnieretId oalearssonmtibt etdn ot eb crSadiop are aalrenutil.

carls14  aren't retinal cells a type of somatic cell? Why not is the mutation not considered in the somatic cell of the child? +9  
omerta  Although this mutation would be considered somatic, I believe the question is just asking you to be specific as to which cells. If you answered "somatic cells of the child," that's quite broad and could apply to almost anything. +11  
kernicterusthefrog  I had the same struggle and thought process. +1  
eacv  There is a Uworld qx that explain this in detail> ID: 863 +3  
arcanumm  I read the answer options too fast so got this wrong. It is a somatic cell type, but somatic in general implies a higher risk for developing other cancers. The hint here is that the physician stated he is unlikely to develop any other neoplasms, so it is a specific double hit mutation in the retina. +7  
almondbreeze  wouldn't she have any possibility of developing osteosarcoma as well? :( +  
almondbreeze  did some reading and it seems like osteosarcoma only occurs in familial retinoblastoma with RB mutation +  
brise  But how can a 5 year old get two mutations to get retinoblastoma? In 5 years?! Obviously doctor is probably wrong LOL +