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Welcome to soph's page.
Contributor score: 9
If they were measuring risk shouldn't it be a cohort study though? By looking at first aid..
I agree. I was hesitating between the two choices. I still think cohort study is better regarding the "risk". I hope this kind of questions wont pop out on the real thing.
I think key here was they were measuring risk though
I also chose cohort, since it is comparing a given exposure.
Yes! Allergic/anaphylactic blood transfusion reaction is within minutes to 2-3 hours.
(pg 114 of the 2019 FA has a list of them ordered by time)
(also allergy / anaphylactic presents with more skin findings (urticaria, pruritus)
The time through me off too. I though ABO mismatch since it occured around an hour. I thought TRALI would take a little longer.
Guys anaphylactic reaction to whole blood doesnt occur much except for selective IgA defi. so look out for prev history of mucosal infection. And it can have all feature of type 1 HS inclding bronchospasm.
I saw hypotension and though anaphylaxis........ -.-
I just dont understand how that is the cause of his altered state of consciousness. Why wouldnt altered affinity of oxygen from HbA1c be correct? A1C has a higher affinity for oxygen so wouldnt that be a better reason for him being unconscious?
HbA1c is more of a chronic process. It is a snapshot of three months. Also, people can have elevated A1c without much impact on their mental status. Other organs are affected sooner and to a greater degree than the brain. DKA is an acute issue.
Can somebody please explain why 'Inability of neurons to perform glycolysis' is wrong?
Probably because they're sustained on ketones.
@snafull glucose is very high in the blood, why would neurons not be able to use it?
@snafull maybe u are confusing bc DK tissues are unable to use the high glucose as it is unable to enter cells but I dont think thats the case in the neurons?
Synaptobrevin is a SNARE protein. Why they couldn’t just give us SNARE I’ll never know.
Cause they're dicks, and they watched sketchy to make sure our buzzwords were removed from the exam
Oh and they read FA and did UW to make sure its not in there either
This toxin binds to the presynaptic membrane of the neuromuscular junction and is internalized and transported retroaxonally to the spinal cord. Enzymatically, tetanus toxin is a zinc metalloprotease that cleaves the protein synaptobrevin, an integral neurovesicle protein involved in membrane fusion. Without membrane fusion, the release of inhibitory neurotransmitters glycine and GABA is blocked. -rx questions!
I think the distribution half-life and elimination half-life was saying that by the time you checked, it had fully distributed (10 half-lifes) and had not been cleared yet (super long half-life)
1000ug= 1mg and 1g=1000000ug
so then 4ug/ml * 1g/ 1000000ug= 0.000004 g/ml
0.000004g/ml * 1000ml/L= 0.004 g/L
80mg*1g/1000mg= 0.08 g
vd= 0.08g/ 0.04g/l =20L
OR another allele has a diff type of mutation because CF is done by like hundreds of diff type of mutation. SO the 70 types that we screened covered one type from one parent but not another that was inherited from other parent.
I put D thinking there was a mutation in another protein that interacts with CFTR....thus u dont have CF but some disease with similar phenotype. Is this wrong bc its simply not the case ??
@charcot_bouchard I think that makes more sense if I understand what you're saying- Probably had a mutation only in 1 of 2 of the same alleles in the analysis but had another mutation in 2 of 2 alleles at a different location not included in the analysis, right?
Hey thanks for finding the image! Do you know why the answer can’t be Chloroquine resistance? I was b/w that and formation of hypnozoites.
I think it's just that Schuffner stippling and hypnozoites are both specific to vivax and ovale species. These species could be chloroquine resistant or sensitive, but if you have Schuffner stippling or hypnozoites, you can definitively say that it's either vivax or ovale.
Species with hypnozoites is not called chloroquine resistant. Chloroquine-resistant species means trophozoite/schizont cant be killed by chloroquine. We dont have enough info to decide whether the spp in the q is resistant/sensitive. But we do know he moved from Honduras to USA 1 year ago.
UW: in africa most malaria species are resistant to chloroquine. he is from hondruas
Can anyone explain the 1-week history of fever? Ruled out vivax and ovale due to 48 hr cycles. Or did they just throw that in as an unspecific symptom.
Yeah haha I had the same conundrum.
If she's breathing deep as she breathes fast, then oxygen is still reaching the alveoli , so arterial pO2 would not be effected.
lmao i'm so freaking dumb i thought she was having alcohol withdrawals because it was relieved by alcohol
Maybe Po2 is unaffected bc its perfusion (blood) limited not difusion limited (under normal circumstances).
PErioral tingling- due to transient hypocalcemia induced by resp alkalosis.