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Contributor score: 176


Comments ...

 +4  (nbme18#43)

Not very clear, but petrolatum aka petroleum jelly is used as a barrier so stuff doesn't get into the wound when the skin is compromised. This helps with anti-microbial defense and wound repair.

https://www.jacionline.org/article/S0091-6749(15)01194-X/fulltext


 +5  (nbme18#44)

X-ray shows a fracture of the surgical neck of the humerus. This where the axillary nerve and the posterior circumflex humeral artery travels.

motherhen  Additionally, axillary nerve supplies sensory innervation for lateral aspect of shoulder. Radial does lateral elbow and musculocutaneous does lateral forearm. +

 +10  (nbme24#41)

Even if you can't interpret the blood smear, this patient is presenting with malaria after being in the US for 1-year. It's highly unlikely that he got newly infected while in the US. What is occurring is a reactivation of dormant malaria (hypnozoites in the liver) that this dude got while in Honduras.

As such this is plasmodium vivax/ovale. What probably happened was that this patient was treated with chloroquine when he was initially infected. This would clear the infection in the bloodstream, but does not kill the hypnozoites in the liver. Treatment with primaquine is needed to clear the hypnozoites, which this patient likely did not receive, hence malaria while in the US.


 +5  (nbme24#40)

There are two types of pneumococcal vaccines for Strep pneumoniae.

The pneumococcal conjugate vaccine (PCV13) is given to children under 5. It is also given to adults age >=65 who are immunocompromised (PPSV23 is also given afterwards).

The polysaccharide vaccine PPSV23 is given to adults, the indications for which I won't go into.

Since this patient is 2-years old he should have received the conjugate vaccine per CDC guidelines.


 +1  (nbme24#31)

POMC is a prohormone peptide chain that gets cleaved into gamma-MSH, ACTH, gamma-lipotropin, and beta-endorphin. There's a nice figure of this in Costanzo (Fig 9-10).

It may help to remember that pathologies with increased ACTH (ie Addison's disease) can present with hyperpigmentation since MSH (melanocyte stimulating hormone) is produced alongside ACTH.


 +0  (nbme24#3)

Tfw NBME said there's no repeats on 23 and 24 and then you get a repeat.

j44n  The NBME is full of shit... they also say there's "no trick questions" +1

 +3  (nbme21#16)

I was stuck between mitral and aortic and went with aortic because the L ventricle looks enlarged, possibly hinting that the patient had aortic stenosis.

drzed  I went with aortic because it looks like the valve has three cusps, while the mitral valve should only have two. Incorrect logic? +2




Subcomments ...

submitted by niboonsh(357),
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xetnrlea aidtrco nrcbah pleussip eth euoprisr rraodhayitp dlnsga sa .?w...l...e.l

yng  Yes the superior part supplied by superior thyroid gland which is a branch of external carotid branch. +  
llamastep1  No they do not, parathyroids are supplied by the inferior thyroid arteries. https://teachmeanatomy.info/neck/viscera/parathyroid-glands/ +11  
suckitnbme  Superior thyroid artery does supply some blood to the parathyroids through anastomoses but the main vascular supply is from the inferior thyroid artery. +1  
okokok1  https://www.earthslab.com/wp-content/uploads/2017/07/070417_1014_Parathyroid1-1.jpg this shows a great visual of how inferior thyroid artery does most of the supplying. +  


submitted by sinforslide(50),
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Teh inepatt dlewak eobtofar no teh bahce adn dah s,shriiorc hiwch amkes mih vblreunlea rfo .V fucivsnilu cte.mraieba .V fviisnuucl cmtbeaeair hsa a vrey opro rns.siopgo

Frmo etdtp:oaU [V". sfcniuuvl]i is the idaegnl ecuas of stssheafcs-eihodllai headts in hte tndiUe estSta. eInitnsfoc edu to V. ucuvilifns are mots omomcn ni ulvniiidsad owh heav ,hrioncc iegrnundly nlle;ssi duinisdlvia thwi rleiv seiaeds or ohteoicahomrsms are ta agettesr rk".is

sinforslide  Also see UWORLD ID: 15255 +4  
suckitnbme  Vibrio species are mostly non-lactose fermenters except Vibrio vulnificus +6  
motherhen  I thought V.vulnificus could only cause food poisoning from eating shellfish; turns out contact with wound infections causes it too (hence why walking barefoot on the beach is a risk factor) +2  
ootscoot  I think they threw this one in here for all the Sketchy loyalists. Gotta keep us on our feet. +  


submitted by breis(50),
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I am ton 01%0 on isht nigeb ccrtore, but I rebfliy ebmrrmee a ticrhsitaPys igsnay atth the tinepat ahs to be euerszi eref ofr 6 omhnts nmumiim adn reerdpfer ot avhe no erezusi iwhitn hte satl 3 eayrs to eb apmaot.miytsc oD wtih taht tmanifoniro atwh yuo wil.l tbu for :Badros 3 sraey.

suckitnbme  Question stem also implies that the patient has been driving already. "has not had any collisions while driving his personal motor vehicle". +15  
cbreland  Also 10 years is a really long time. Just didn't seem like a good answer +  


submitted by tissue creep(113),
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lMid naijdecu htiw aernsiced cujndgauetno ni na derol wlofel si esdaderce tUrlPeyrcnaosauDfsn-eulrg tavit.icy iyaPrrulclta ni otctnxe of srstse toye(dpeacpm)n

pg32  Went with hepatitis because of his recent surgery. Seen problems like this before where recent surgery means they were given inhaled anesthetic that can cause hepatotoxicity/hepatitis. That, along with the elevated AST/ALT and unconjugated bilirubinemia (signifying liver losing its ability to conjugate bilirubin due to inflammation) made me pick hepatitis. Why is that wrong? +  
suckitnbme  @pg32 AST/ALT are only slightly elevated. The patient also is not particularly symptomatic. He's really not that sick. Hepatoxicity is also most associated with halothane which is no longer used in the US. It would be a different story if the patient had surgery done in a different country (as is common in Uworld questions on this) +5  
mumenrider4ever  I don't know why NBME uses ALT/AST reference ranges from 8-20 u/L when the reference ranges for uworld are 8-40 u/L. So maybe his liver enzymes aren't really elevated since they're below 40 +4  
cheesetouch  Can someone refute 'surgical trauma'? +  
cancelstep  Appendix is pretty far anatomically from the bile ducts. Also damage to bile ducts should cause direct hyperbilirubinemia since there's no problem with conjugation versus Gilbert syndrome which causes impairment of UGT +4  


submitted by pg32(155),
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Cna oneany lipxaen ywh the alspei rtaonotnnceic is os gihh if heetr si na eiuss tiwh PLL ni crer?hnaymhmycliiooep

garima  due to pancreatitis +5  
neovanilla  ELI5? +  
suckitnbme  @neovanilla Type 1-hyperchylomicronemia has increased risk of pancreatitis +  
makingstrides  I don't understand why this isn't hypertriglyceridemia because this also causes acute pancreatitis. Maybe because overproduction of VLDL isn't an answer? +  


submitted by rainlad(23),

How do you rule out Protein C deficiency in this case? doesn't that also increase risk of thrombosis and miscarriage?

suckitnbme  @rainlad Protein C deficiency doesn't cause elevated PT and aPTT. I believe they're both normal and assays for the disease measure protein C activity. +4  
drzed  Protein C is an anti-coagulant, so if you lack factor C, then you have MORE clotting factors. This means that the PT and PTT would not be prolonged. +3  


submitted by majic(9),
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ETH STMO OMCMON ureot fo xoTo irtnnsmssaoi ni dstlau in eth SUA si iositnegn fo uddenkcreoo okr.p nEev fi cta terlit si an ,poiotn euorddocken krpo si llits emor mm.onco

yotsubato  Also another fun fact. Most people in France are infected by Toxo (like 80%) because of how they eat meat. (Very rare) +2  
madojo  To add on might be TMI but most people have Toxo but are asymptomatic because its in its latent form as a pseudocyst and its not untill you are immunocompromised that it strikes +  
suckitnbme  This patient also probably got toxo in Brazil +  
luciana  JFYI people in Brazil love to eat rare meat at barbecues +  


submitted by xxabi(259),
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tenSt rtsmhsoobi sv tseis.-serno enStt siorhsomtb is an teauc iuclsoonc fo a norayorc trryea esttn, cwihh efnot ssrutel in atceu onrrcyao es.yonmdr naC be erdvetpen by adlu nlittatlaeep eayhtrp ro uguretl-ingd nt.tses setosn-Resi is eth aaglrud oainrgnrw of het estnt uneml due to ltnenoamii lpoernr,oiifat gtesnilur ni ngnlaia .pssytmmo

sunshinesweetheart  so just to clarify - it's the "symptom-free for 3 months" that rules out thrombosis? +6  
hpsbwz  It's moreso that at rest there's no changes, but during exercise there is. Like the pathophys of stable angina. +6  
suckitnbme  I think it's more because of the 2-month history of PROGRESSIVE angina sx with exertion. This points to a chronic process rather than an acute event. +  
alienfever  Drug-eluting stents prevent re-stenosis (rather than thrombosis) by releasing sirolimus which by blocking cell proliferation. +2  


submitted by m-ice(340),
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Teh tetnpia shsow on nsgi fo ritccola ,iityvtca but sah emso amenrsbit oicnftun t,anitc whhci ielsipm hes si in a rofm fo tnsrisetpe itvaveetge .estta She hsa a gvilin illw taht gsneadseit hainalccem entiatilnvo oulsdh eb nitsindcodue if that ntouiaist srie,sa so ew umts olfwlo it dan eakm not tatmept to atui.stceser

lfsuarez  Why would the second part of that be correct when there is not mention of a DNR? +13  
ug123  DNI and DNR are different right? This patient had a DNI. Why would we assume it to be DNR too? +4  
sherry  DNI and DNR are indeed different. But it is not the case here. The patient needs to be extubated means she did not sign a DNI or DNR in the first place. I assume her living will is more like terminate supporting treatment in a vegetative state. So there is no need to do resuscitation anyways. But I agree this is not a good question. +2  
shayan  "The patient has signed the living will and is consistent with her directives" but the stem doesnt tell has what is in her living will about the extubation? we are extubating on the request of her husband? this is confusing ! +5  
criovoly  I believe this question was not well constructed... it's one of those! +  
suckitnbme  @shayan extubating at request of the husband because he's following what's in her living will. Following that line of thought, the patient probably wanted withdrawal of care if in a vegetative state. +  
luciana  I understood same as @shayan that she wanted to keep intubated... now reading it again I feel extra dumb with my poor reading interpretation skills +  
coldturkey  @lfsuarez CPR(if the need arises) , for this patient (barb overdose and hospital setting), she will be intubated to get and maintain airway access. However ,she is against any mechanical ventilation as per her living will. Hence, we cannot perform CPR on her. +1  
furqanka  I too believe DNR and DNI are distinct but UW 1124 says - A DNR order indicates that a patient should not undergo CPR. this includes bls (mouth to mouth breathing, chest compression) as well as advanced cardiac life support (intubation, mechanical ventilation, defibrillation, and administering medications such as vasopressor or epinephrine). Additional wishes such as the desire to not be fed artificially or any other limitation of care can be specified. +  


submitted by charlie(10),
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I htkni etr'hse a toyp on ttha usetn.qoi 2HSM nege mtaionut si the lrticup rof CN.CHP Fro MSH2 eg,en conrcgadi to waht I sjtu dcrash,ee suecas Mitanlgan Hihmrepatery Stibypliteu.cis

noplanb  Yeah I think it should be MSH +1  
suckitnbme  Good to know I wasn't tripping out when I did this question +2  
thisshouldbefree  $60 +10  


submitted by m-ice(340),
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HGM oAC eesdutcaR ntirbiohsi rnepevt eht reliv from nheisygstzin sti won esl.erohlcto In drero ot maniniat tsi edne orf cs,eetorhllo teh lveri ash no iocehc yb to sneeirca tsi LLD oprrecte ensrospexi ni drore ot take rhlcoeeltso morf the oodbl.

suckitnbme  Not sure why NBME felt like they needed two questions on statin MOA on this form. +5  
makinallkindzofgainz  because they didn't even realize it because they make insanely low effort practice exams with awful formatting and vague vignettes, yet here we are paying 60 bucks a pop for "high quality" exams, gimme a break. ok i'm done venting +4  
madden875  stop whining. no one asked you to buy the exam^ +4  
neoamin  Why does anyone scramble this site? >< +1  
neoamin  and how about lipoprotein lipase? +  


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How od uoy nhsgtudiisi hist fmor ursitaetlc rioots?n sI ti sujt csaueeb it aersdtt in eth flte klf?na

neels11  and there's no mass in the scrotum, whereas testicular torsion will have that "bag of worms" feel (along with a lack of cremaster reflex) testicular torsion usually happens in a younger age group +11  
medpsychosis  @neels11 I would like to clarify a piece of information. I believe you are confusing Varicocele with Testicular Torsion. Varicocele will present with "bag of worms" feeling. While the absence of cremasteric reflex is a sign of testicular torsion. +16  
johnson  This is the classic "loin to groin pain" of nephrolithiasis. +7  
suckitnbme  Testicular torsion would also tend to have a unilateral high-riding testicle. +  


submitted by sangeles(9),
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To em ti nsdsuo omer lkei esvun .liespxm heT omst onmmoc cplyialar anmiotomarfl is vuens mixpsel, hwhic festafc rome nhat lfah of nisn.tfa esuNv ipl,exms or lamson“ a”ptch, nlosesi rea pkni, nef-delilid tepchas ttha tned to coruc ni ieindlm ,saciolton mtso fryulenteq no the naep of hte enkc, ,alllagbe iesd,yel ,ssieln/po ac,psl dan sarlca geonir ltsracioH,lyi illqloouac setmr such sa osr“kt tbie” ep)a(n adn “aleng ssik” laeheea(dgo/ralflb) ederrrfe ot vensu lixesmp snseloi ni ultrapairc iamatanolc rin.oesg ekUinl WSP nad mtos terho alcsuarv oltrmamn,aiosf msot vsuen lsxepim soniles sserger niwiht the frist 2 saery fo flie ilnilacC tfetnfirinaideo of nevus msxeilp ormf WP,S lpseiacyel on itliain r,nptseneoita acn be itdi.fuflc ieLonss thwi lthreig knip o,orlc diinlem ni,otaloc and ntdiinitcs rodesbr arofv nvues lm.sixep r/nPvsah/.m/ww.m8t56p9l.w:psochc/gb/nMi.51ticei/C3tln

suckitnbme  I agree that this nevus simplex and not a strawberry hemeangioma. Of note, nevus simplex lesions are flat lesions formed from dilated capillaries. Lesions on the face tend to regress while lesions on the back of the neck typically do not. https://en.wikipedia.org/wiki/Nevus_flammeus_nuchae +1  
misterdoctor69  The main thing that bothers me about this question is that if it is indeed nevus simplex, it's definitely a very non-typical presentation. Nevus simplex most commonly occurs on he back of the neck/midline locations plus they are pink in color. The lesion described in this question is purplish (not pink) and it appears on the right side of the face (ie. neither back of neck nor midline). We can definitely rule out nevus flammeus because that is only seen in the setting of Sturge-Weber syndrome, which this patient has no signs of. We can also rule out strawberry hemangioma because such a lesion would be raised, not flat. +5  
osteopathnproud  To add to that, I guess in the NBME world you can not have a nevus flammeus if there is no Sturge-Weber syndrome, in the real world most nevus flammeus are not associated with Sturge-Weber syndrome, but if a patient has Sturge-Weber syndrome then he is very likely to have a nevus flammeus +  
larryd  I think this is an infantile or a congenital hemangioma, based on the fact that they can also be flat/plaque-like, and are found in greater frequency in girls (like this pt). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211219/ +  


submitted by madojo(177),
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nCrycoilsop is an snaunpumotseripsm htat lbokcs T llce tiniacotav by thibininig LI,-2 os we wkno tthsa tno it.rgh mlioapypdhhoeCsc is an llintgkaya en.gta ocinubrDxoi is na ttnrmouai ontiacibit htat geeretsan efer casrldia and secsau bksera ni .DNA orfil5auluc'or si aiteossac ihwt npyriimide nhy.tssise egnLiva isrciinVtne ihhwc is a icsaptoenl gudr ttah skwro no sroumluiebtc t(ehro sgrdu atht do stih ccceii,lohn ixelclta.pa

sA doennmeit eaar,yld the elcl si skctu in mhtaepaes nad nntcao ogruedn eth tisapreone shpana.ae M eyccl asrtre is cdssoeaati twih vsireintinc adn hichw eth cttmiio npeidls ihcwh si hatw sapstaere teh mosscoomhre si nto gi.mfonr

suckitnbme  The funny thing is that the image seems to show that the spindle did in fact form. +11  
spaceboy98  EXACTLY They showed the mitotic spindle is formed, so paclitaxel would be ok, but for vincristine, the damn thing would not even form +4  


submitted by neonem(571),
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hTsee rea ugot slr.atsyc I possepu teh tbes way ot tadfrfeieetin ihts scea mrof getspoduou si that eht arstslcy ear phras pm;&a saepnheeedld- dan tno de.opi-smhbdrhao

sympathetikey  Yep. They tried to throw you off with the picture, but the wording in the stem says its a "photomicrograph" -- not exposed to plane polarized light, where you would see the negative birefringence. +18  
linwanrun1357  Why is NBME so mean to us. Do those mean a lot in clinic? +  
suckitnbme  @linwanrun1357 I highly doubt you would be looking at your own joint fluid aspirates instead of sending it to the lab. +3  
nnp  what those yellow white nodules signify? +  
peqmd  In clinic gout is typically a clinical diagnosis. If you can treat w/ NSAIDs instead of aspirate you would do that. You would aspirate if you are considering septic arthritis so you can get culture. I don't think anyone aspirate for heck of it. +  
lowyield  @nnp, the yellow white nodules are tophus which is a sign of chronic gout, characterized histologically by aggregates of uric acid crystals, can show up as skin nodules most commonly on external ear, olecranon bursa or achilles tendon (pg 467 FA 2020) +  


submitted by gonyyong(108),
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tWa'sn urse atobu ,tsoehr tub agoarphmmym ofr egalner iotnlupoap i'stn odreedmncme tilnu 04

_yeetmasterflex  Also wouldn't mammography be secondary prevention since you'd look for asymptomatic disease already present? +22  
suckitnbme  USPSTF recommends starting screening at age 50. 40 by patient choice if there's risk factors. +2  
j44n  @_yeetmasterflex thats a good point i didnt think about that +  


submitted by ameanolacid(26),
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ilsotsAsocerrhe si eth OTSM mmonco useca fo nrlea teryar sot.ntei.wi.shs sromulbraiucf isapaydls bngie hte ECDNOS toms mmcono eaucs eevn( hhotug ti si pgteitmn to hocose isht toipno riocnsgeidn hte tnpi'esta h.gmaceiprod)

xxabi  Is there a situation where you would pick fibromuscular dysplasia over atherosclerosis if given both options? Thanks for your help! +5  
baconpies  Atherosclerosis affects PROXIMAL 1/3 of renal artery Fibromuscular dysplasia affects DISTAL 2/3 of renal artery +52  
gonyyong  Why is there ↓ size in both kidneys? This threw me off +3  
kateinwonderland  @gonyyong : Maybe because narrowed renal a. d/t atherosclerosis led to renal hypoperfusion and decrease in size? +1  
drdre  Fibromuscular dysplasia occurs in young females according to Sattar Pg 67, 2018. +11  
davidw  Normally you will see Fibromuscular dysplasia in a young female 18-35 with high or resistant hypertension. She is older has a history type II DM predispose you to vascular disease and normal to moderate elevation in BP +9  
suckitnbme  @gonyyong there's bilateral renal artery stenosis. The decrease in size of both kidneys should be from atrophy due to lack of renal blood flow. +3  
tyrionwill  1 year ago, she did not present any physical or Lab abnormalities. This means she must not suffer fibromuscular dysplasia, otherwise she must have presented renal abnormalities for a long long time, or even before DM-2. +2  
rockodude  a little surprised that atherosclerosis leading to bilateral renal artery stenosis and shrunken kidneys could happen that quickly after everything was A okay the year prior +1  


submitted by gonyyong(108),
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ehT kid hsa yantsicaegom deu to yutprbe xssec(e esneostrteot → )shTigenoert s goes wyaa trnyalalu reaa(ptpyln ni 12 to 81 to)snmh

I ihknt uyo o'tdn vaeh ot do dloob ettss abueecs he sah rnmola xlasue demopnteevl for hsi gea dan ehert ear on rhote sg?isn

osler_weber_rendu  How does telling an "embarrassed kid" that he will have big tits for 12-18 months help?! +29  
howdywhat  my exact thought, telling him that it will last for somewhere around a year and a half doesnt seem so reassuring +1  
suckitnbme  I thought it was reassuring in that the kid is being told this isn't permanent as well as that this isn't something serious. It's important to inform him about the prognosis. +8  
thotcandy  "don't worry your gynecomastia isn't permanent, but the mental scars from the bullying you will receive in HS definitely will be :) good luck!" +4  
therealslimshady  What is the gynecomastia is from a prolactinoma? +  
misterdoctor69  @therealslimshady the gynecomastia is from the sudden surge of testosterone during puberty being converted into estrogen => more breast tissue. +3  
mnunez187  My breasts are not rubbery nodules, thank you very much! +  


submitted by lsmarshall(415),
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iMasalpeta - A seeblvrrie dapative psoeersn in ihhcw ehret si ieormRgagnmp"r fo stme aneselprcllemeŽtc of one elcl pyet by aheront atht can apdta to a nwe sss.te"r otBh rae mnroal .lelsc rayiRpeotsr eert sudohl ton aehv msusuaoq clsle tniul yarspiroret oonrhelcbsi or(ebef t;ath diblaocu in m.ter ornb. ;> nmlrucao in rn.obhc g&;t etfpioredisaduts alnourcm ni lreag. ..hcbnr)o

shayan  if its a metaplasia, then how it be normal ? I mean Metaplasia is not normal? +2  
artist90  i got it confused bc the question stated that there was a mass in one lobe of lung and i didn't knew that squamous metaplasia also presents as a mass in lung. i missed that on biopsy they were clearly stating squamous metaplasia. +4  
suckitnbme  @shayan The term "normal" in the answer is used to indicate that the cells appear normal (meaning appropriate size/architecture/appearance). Remember that metaplasia is a normal response to stress. +8  
jurrutia  Metaplasia is not normal (in the sense that you only have metaplasia as a reaction to stress, but under not under normal circumstances), but the cells in metaplasia are normal. When they become abnormal, you get dysplasia. +  


submitted by krewfoo99(93),
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sThi loucd syiael be euocndfs iwth aSouqmus lCel armcCinoa as ehty ear eicbdgsrni a asm.s utB i kitnh eht yek icderfenfe is htta hyet ntoinme LPTAI.EAMAS If ti swa slspyaad,i enht ti owuld eavh bnee eca.nrc

usmlecrasherss  metaplasia also can lead to cancer FA p206 2019 +  
suckitnbme  Dysplasia is not cancer since it is, in theory, still reversible. Only when it becomes irreversible is it a carcinoma. +1  


submitted by snafull(4),
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anC osbydemo lxpanei hyw thsi si tno a eognifr ybod mgl?uraano

yb_26  because they mention scattered fragments of foreign material (pt presents 2 months after c-section, sutures are either removed in 1 week or dissolve in few weeks (depends on type of suture material) +  
suckitnbme  I think it IS a foreign body granuloma. The sutures are supposed to be removed or dissolve but sometimes one gets left in. The question says foreign material and sutures are often polarizable. +5  


submitted by beeip(124),
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Can yeanon xanlipe wath yrhee't tginget ta rh?ee Hwo nac ahonetelbhc eb iedcatnid and tcnidnracaoeit?d

sniperx3  I think it's because Bethanechol acts on M3 receptors which can treat her urinary problems but it might exacerbate her asthma symptoms since there are M3 receptors on the lungs. +37  
suckitnbme  I definitely had to read this question multiple times to understand it. +2  
brotherimodu  I read it like 6 times and gave up +2  
motherhen  I definitely had to read this question multiple times to still not understand it +1  


submitted by sweetmed(144),
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The Hma etts is a tset ueds in the gdasionis fo saxoalrymp cntauolrn onbiroimlgehua NH().P hTe ttes elsnovvi lgpiacn rde bdool llsce in idml iac;d a sitveiop rutels edianercs( CRB irfitgy)al stdaciine PHN

suckitnbme  It's so obscure of a test that wikipedia only has 4 sentences on it. +2  
pathogen7  FA2020 added the Ham test to PNH I believe! +  
pathogen7  Whoops no sorry I am wrong. They did add something called the EMA test to spherocytosis though. +  
snripper  Ham test has been replaced by flow cytometry now. So fck off, NBME. +1  
pseudomonalisa  I remember it like this: PNH occurs at night due to mild respiratory acidosis (slower respiratory rate), which activates complement which destroys RBCs. The test is essentially doing the same thing, putting cells into an acidic environment -> dead RBCs. +4  


submitted by neonem(571),
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nbplreinleeoeCto leang asms = tuiebValrs samnowcnah K(AA uatscioc amru.e)on erDidev mrof nnawhSc ,cllse whhic rae of lrunae scret rgo.nii

yotsubato  Ugh. Of course they dont put schwann cells as a choice. So I pick oligodendrocytes like a dumbass +35  
subclaviansteele  Same^ +1  
madojo  Schwann cells = PNS Oligodendrocytes = CNS +3  
suckitnbme  NBME loves their neural crest cells +4  
wrongcareer69  How much do they pay these testwriters anyway? I can use a thesaurus too +2  
osteopathnproud  @suckitnbme they do love their neural crest cells, I have chosen neural crest cells for every single answer choice I see it in and I believe I gotten 90% of them correct, if something doesn't click or you don't know, I would keep neural crest cells as a very possible answer lol +  
faus305  AMERICA EXPLAIN +  


submitted by urachus(16),
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otn EOP cb sit' kginsa hst'wa emda mrfo hte nobe mrwr.oa OEP is ofrm dneiky

lilyo  Thanks, I was wondering why EPO was not correct. So EPO synthesis would be stimulated in case of blood loss? its just wrong becase they ask specifically what is going to be produced in the bone marrow? +2  
suckitnbme  @lilyo yes because it's specifically asking what the bone marrow is synthesizing. EPO would also be upregulated but this happens in the kidneys. +3  


submitted by drdoom(883),
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eTh stme si dcebsgriin qeasuele fo osrriotep ioferrin clbeelarre yrerta oicucnos,l lisugnret ni enllgareWb meyrsdno. H’eres a neci mahitccse fo eth cetfdeaf icelun dan bnria mste :inrsego

/eixt1ifya.pgt8vmgj/ots9mpAm_th/uc/:is.learg.SBd/pt3

... adn a -6nmutie ubuYoTe ieodv tath kwlas uyo ugrthoh ti:

wt8h/B/?wccoeth.9/paysuwSgv_b.=m31Aottu:wtp

nbme4unme  Great video! Very, very solid review of brainstem anatomy. +  
suckitnbme  This image was surprisingly interpretable for NBME standards +13  
aneurysmclip  and the fact that all you needed to know was the side of the lesion to answer tbh lmao, but other than that localizing to medulla wasn't hard. +4  
medguru2295  Actually, they were quite nice. You didn't even have to know what side. There was no option for left medulla. +3  


submitted by soph(60),
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I kihtn key erhe si ehyt era ennatvitgiigs eth topseshihy fo mmuaotn fo niesacrni etraw esiaersnc RSIK of ..ccraen.. tebs ayw to erseaum kirs si sace ntlrooc.

nbmehelp  If they were measuring risk shouldn't it be a cohort study though? By looking at first aid.. +3  
270onstep1  They both can determine risk. Key here is the time efficiency of case-control studies when compared to cohort. +  
suckitnbme  Case-control only determines odds ratio which is not calculating risk. In rare diseases the odds ratio can be used as an estimate of the risk ratio however. +1  


submitted by keycompany(310),
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Igema oshsw esnCetcr Sgin, a conmmo dnnifgi ni bmlaionAd oAtrci musryensA eud ot amlur outsbrhm oicnc.ouls

happysingh  crescent sign is a finding on radiographs that is associated with avascular necrosis, NOT aneurysms !!! what you're seeing is Calcification of wall of the aortic aneurysm +12  
sabistonsurgery  @happysingh - Thank you. You are correct indeed. +  
suckitnbme  Adding on, this patient is a >65 yo Male with a 120 pack year smoking history. Both are significant risk factors for AAA. +  


submitted by krewfoo99(93),
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VHP hsa ihgh fntifayi for squsamuo i.timphuele Treu lovca csdro eavh sqsauumo miuetlih,pe huts PVH tends ot ogrw etrhe

suckitnbme  Specifically stratified squamous epithelium I believe. +1  


submitted by nlkrueger(44),
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.... lduow we lelary keat hte wrod fo a ierndf owh dyfleiniet ta'nc be dmen?ricof I feel ilke iths is dgiesnlmai

lispectedwumbologist  All the other answer choices make you come across as an asshole. Easy way to ace ethics questions is to just not be an asshole +9  
seagull  I would be a bigger asshole when the family came I'n after I pulled the plug...opps...but the friend said +31  
dr.xx  The patient has no wife, children, or close relatives... +3  
nwinkelmann  @lispectedwumbologist this is going to be my technique, because I've gotten a couple of these wrong, but I completely agree with everyone else's sentiments of suspicion of going off what a friend said without any confirmation about state of advance directives, etc. It's really dumb. +3  
paulkarr  With these questions; you have to take what NBME says at face value. If it says no family, he really does have no family. This friend is also claiming that the 78 y/o said this about himself, so we know it's the patients wishes rather than someone else's wishes for him. (A son saying he can't let go of his father yet despite the patient's DNR type of situation). +1  
suckitnbme  I think the point here isn't that we would take the patient off the ventilator because the friend said so. The answer is saying "Thank you for your input, we will take that into consideration." It's completely non-committal. +7  
vivijujubebe  they say no close relatives, which means he could have remote relatives, relatives must be asked before listening to a stranger/friend's words..... +  


submitted by hayayah(1077),
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rfkeao-WfiecosrnkK .rdymsone notD' hvea to be an aloicohlc to teg s,thi juts alulysu is aldtree ot hmoicsalol / inteaimh cedynei.fic

d_holles  Yeah the negative EtOH screen threw me off +3  
dr_jan_itor  Why cant it be early alzheimers and hippocampus? She could easily have been a former prominent physician and member of city council. Am i supposed to assume that simply because shes disheveled and poor hygeine that she must be an alcoholic homeless person? It also mentions no symptoms of nystagmus, ataxia, etc. +2  
kimcharito  it said broad based gait and nystagmus +9  
lilmonkey  She is/was an alcoholic and appears pretty much homeless, just not drunk at this moment. +  
fatboyslim  @ dr janitor. The question says "physical exam shows a broad-based gait and nystagmus." +  
suckitnbme  NBME questions also stereotype the shit out of their patients +5  


submitted by rainlad(23),
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uwdol we be wrirode ubota isugn FSGC- vgien ttha eh hsa aectu mkeea?ilu louwd ti iesumtlat rohwtg fo his canerc lcel?s

suckitnbme  I think we're assuming that we eradicated the leukemia with the chemo. However at the same time a lot of normal stem cells were also killed off so we give GCSF to help recovery especially since they have an infection. +  


submitted by nuts4med(6),
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I saw kgninhit rCons’h bacseeu fo eth owrgnanri of teh uneml adn eht ircutpe eedems keli erthe saw perigcne f.ta oNw atht I hkint tuboa it tuoh,gh the LLQ dan poacntsiitno udshol aehv edl drstoaw isituiervcltid tytper qkiuy.cl

suckitnbme  Also agree the narrowing of the lumen plus the pic is pointing towards Crohn's. The acute systemic sx of fever and chills is what made me go with diverticulitis (along with the hx of increasing constipation). +1  
pg32  Why does the question say there is NARROWING OF THE LUMEN? Does that happen in diverticulitis? I went with Chron's at the last second against my better judgment because Chron's can cause strictures/narrowing of the lumen. +2  
lola915  FA 2020 pg.383 Most common area for Diverticulosis to take place is the sigmoid colon and diverticulitis can cause obstruction (inflammatory stenosis). The key here is recognizing the risk factors (>60, chronic constipation) and signs of acute inflammation (fever, chills and LLQ pain). +1  


submitted by hayayah(1077),
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Saroedncy rrypsrhhmoyepaitida l(uulasy t/d rhcconi aenlr ).lruaief

abL fnsginid eicndlu ↑ THP (roeepssn to olw lcu,aicm) ↓ usmre uccilam ler(an )lafre,iu ↑ serum toephhsap al(ren aulief)r, adn ↑ eiallakn hoptpahsaes HPT( antiagctiv Btoso.sesal)t

haliburton  also remember that in renal failure, 1-alpha-hydroxylase activity is down, so there will be less activation of 25-hydroxycholecalciferol to 1,25-hydroxycholecalciferol, which is a key mechanism causing hypocalcemia. +2  
cr  why not increased 25-hydroxycholecalciferol?, with the same logic haliburton explain +  
nala_ula  Increased phosphate, since the kidneys aren't working well, leads to the release of fibroblast growth factor 23 from bone, which decreases calcitriol production and decreased calcium absorption. The increase in phosphate and the decrease in calcium lead to secondary hyperparathyroidism. +1  
privatejoker  Probably a dumb question but how do we definitively know that the ALP is elevated if they give us no reference range in the lab values or Q stem? Everything stated above definitely makes sense from a physiological standpoint, I was just curious. +1  
fatboyslim  @cr the question asked "the patient's BONE PAIN is most likely caused by which of the following?" Increased levels of 25-hydroxycholecalciferol might exist in that patient, but it wouldn't cause bone pain. PTH causes bone pain because of bone resorption +1  
suckitnbme  @privatejoker ALP is included in the standard lab values +  
makinallkindzofgainz  @privatejoker ALP is listed under "Phosphatase (alkaline), serum" in the lab values +1  
pg32  Why does AlkPhos increase in renal osteodystrophy? The PTH would be trying to stimulate bone resorption (increase osteoCLAST activity), not bone formation (osteoBLAST activity). +  
drzed  @pg32 the only way to stimulate an osteoclast in this case (e.g. via PTH) is by stimulating osteoblasts first (thru RANKL/RANK interaction), thus ALP increases. +1  


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It sdai ti swa atafl ot lmase in u,orte and eth oeutqnsi deska tauob evli obrn gpsnfro.fi eScni the lemas tenra’ bineg obrn ni teh rstfi pl,eca I dsai 0%5 amfesle adn 0% el.msa

hungrybox  fuck i got baited +31  
jcrll  "live-born offspring" ← baited +23  
sympathetikey  Same :/ +  
arkmoses  smh +  
niboonsh  why is it 50% females tho? +2  
imgdoc  felt like an idiot after i figured out why i got this wrong. +2  
temmy  oh shit! +  
suckitnbme  This isn't exactly right as males can still be born as evidenced by individuals III 6,9,11. This basically an x-linked recessive disease. A carrier mother can still pass her normal X chromosome to a son (50% chance). It's just that the other 50% chance of passing an affected X chromosome results in death of the fetus in utero. Thus all males actually born will not be affected. +2  
makinallkindzofgainz  @suckitnbme, Correct, but if you're a live-born male, you 100% for sure do NOT have the disease, so the chance of a live-born male "being affected" is 0. +3  
spow  @suckitnbme it's not X-linked recessive, otherwise every single son would be affected and therefore have died in utero. It's X-linked dominant +3  
qball  Jail-baited +  
srmtn  correct @spow affected females= X linked Dominant +  


submitted by yotsubato(1032),
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yWh is isht ONT oa?ichcndr hTsree gnhtino ehre atth rlseu it t.ou

drachenx  Chancroid is described as an ulcer.. whilst in this question they mentioned "vesicles". Pretty much only herpes is vesicular +6  
whoissaad  They mentioned ulcers too. I chose chancroid as well, couldn't find a clue to rule it out. Also thought "discharge" was pointing you towards a bacterial infection. But guess I'm wrong :) +  
emmy2k21  I think NBME/USMLE writers make the assumption the patient is in America unless specified otherwise. Chancroid is not common in the US. If the question stem mentions a developing country, then chancroid can make your differential list. +1  
selectuw  for chancroid, there may be a mention of inguinal lymphadenopathy +2  
samsam3711  Also with chancroid questions they want you to differentiate it between chancroid and syphilis, (eg. Painful vs. painless) and is usually described as a much larger ulcer that is painful (not vesicular as in this question) +  
suckitnbme  Also believe that chancroid does not presents with systemic symptoms like in this vignette. +  


submitted by welpdedelp(227),
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tI swa csa,ibse chhwi si trmtiaentds en.o-orpspeorn

welpdedelp  **person-person lol +6  
suckitnbme  NBME loves their scabies +15  
dentist  did you get scabies from "burrows" and "night itching" +  
pg32  My question is where do you get scabies originally? I knew it was transmitted person-to-person, but thought it has to originate somewhere (a pet possibly?) so I went with pets. The internet only seems to say that you get scabies from another person with scabies, so the question remains: where do people contract scabies from? +  
leaf_house  @pg32 , long quote: + "Sarcoptes scabiei mites seek the source of stimuli originating from the host when they are off the host but in close proximity to it. This behavior may facilitate their finding a host if they are dislodged from it and contaminate the host environment. Thus, direct contact with an infested host may not be required for humans and other mammals to become infected with S. scabiei. In the case of human scabies, live mites in bedding, furniture, toys, and clothing can be a source of infection. Sarcoptes scabiei var. hominis have been recovered from laundry bins in a nursing home." + from here: https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-017-2234-1 +  
zevvyt  to summarize leafhouse: Fomites +1  
surfacegomd  FA 2020 p.161 "transmission through skin-to-skin contact (most common) or via fomites" +  


submitted by gh889(127),
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mrFo dSoknanokeryhouHe on idde:rt

athW eht eqnuisot si ienggtt ta is het itymhstcepa hnaci asw .aeprds tI saw a eirlbert ayw of rdwogni i.t

uroY ortirnea opmayslhutah is spielesbrno rof gooclin reeuatsf adn is rdune aesamahtpcyript rltncoo. A eolsni ulodw seauc yip.teahrermh

ruYo ietrrsopo yhsmatluhoap si bnolrepessi ofr tnahieg hwne e'ryuo dcol nda to teeaergn hte vFere oenerssp adn si rendu ctmihtsepay otnclro. A oneils loduw ueasc yrhi.maeptoh

In tsih intoqseu ti is imlpys kansgi a senpro egst kisc, lpatuohmyash was dprsa,e htwa .enphsap

Arw:nes saloyputhmha lliw tlils eb beal ot eaeevtl est dyob emeratpetru ot altbte icnf.oniet

:iHtn IF heyt vgie a setqonui iismlar ot sthi ubt rwedreod to ldunice a eisonl of teh tthycaepmis esbrfi or of hte mshta,yoauhpl oyu lwudo ni utnr TON eb ebla ot egteearn a eefrv ropsesen ot iti.enfnco eTh spalaohhytum owuld eb ilnyrtee eunrd tcramyatphsiape lrontco

hsiT sdda erom xnotcte to hte cfta hte Q ttseas atth het astyemcishtp saw sadrep

oslerweberrendu  So, this says sympathetic also spared and hypothalamus also spared. Then what was wrong with this clinical case?? +  
adong  i think the sympathetic system is actually impaired b/c it's cut before it can "outflow"...at least it's the only way this makes sense +3  
suckitnbme  I agree. I think the question stem is saying the sympathetics were lesioned. Not that they were spared. +3  


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ieiomsmnagn utnco sa cganhnnei inselos? tsih( otnmcem sedne to eb emor hnat 50 rechcsarat lap.)pyanetr

goldenwakosu  I think it’s because meningiomas are able to calcify (aka sometimes they have psamomma bodies). I got this question wrong too but I totally did not completely register that the tumor was in the dura (interhemispheric fissure + central sulcus). Hope that helps! +2  
pipter  the only reason I got this right was because they described the tumour as being near the falx cerebri. +2  
fcambridge  Other hints include being described as round and seen in a female. Both indicative of Meningioma +17  
niboonsh  also meningiomas typically present with seizures or focal neurological signs +  
suckitnbme  I thought enhancing meant it uptakes contrast. Meningiomas are commonly enhancing lesions per Radiopaedia. +  


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urO ttille efidrn ahs a rsruPivavo feontic,ni wchhi snectif otyirdehr urprrs,eosc anuicgs runinrtitoep fo yrreotythec drci.utnoop Tshi is the asme wya it sucsea dshyopr tailfse in nbruon babeis nda ailtsacp inmeaa ni lkcsei lc,el c.te

gainsgutsglory  I get Parvo has tropism for RBC precursors, but wouldn’t it take 120 days to manifest? +  
keycompany  RBCs don’t just spill out of the bone marrow every 4 months on the dot. Erythropoesis is a constant process. If you get a parvo virus on “Day 1” then the RBCs that were synthesized 120 days before “Day 1” will need to be replaced. They can’t be because of parvovirus. This leads to symptomatic anemia within 5 days because the RBCs that were synthesized 125-120 days before the infection are not being replaced. +27  
drdoom  @gainsgutsglory @keycompany It seems unlikely that “1 week” of illness can explain such a large drop in Hb. It seems more likely that parvo begins to destroy erythroid precursors LONG BEFORE it manifests clinically as “red cheeks, rash, fever,” etc. Might be overkill to do the math, but back-of-the-envelope: 7 days of 120 day lifespan -> represents ~6 percent of RBC mass. Seems unlikely that failure to replenish 6 percent of total RBC mass would result in the Hb drop observed. +  
yotsubato  He can drop from 11 to 10 hgb easily +3  
ls3076  Apologies if this is completely left-field, but I didn't think this was Parvovirus. Parvo would affect face. Notably, patient has fever and THEN rash, which is more indicative of Roseola. Thoughts?? +4  
hyperfukus  @is2076 check my comment to @hello I thought the same thing for a sec too :) +  
hyperfukus  also i think you guys are thinking of hb in adults in this q it says hb is 10g/dL(N=11-15) so it's not relatively insanely low +  
angelaq11  @Is3076 I completely agree with @hyperfukus and I think that thinking of Roseola isn't crazy, but remember that usually with Roseola you get from 3-5 days of high fever, THEN fever is completely gone accompanied by a rash. This question says that the patient has a history of 4 days of rash and 7 days of fever, but never mentioned that the fever subsided before the appearance of the rash. And Roseola is not supposed to present with anemia. +3  
suckitnbme  @Is3076 another point is that malar rash refers to the butterfly rash on the cheeks that is commonly seen in lupus, so the face is NOT spared. +  


submitted by marbledoc(0),
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yhW wodul uoy aks hte enttaip to niytiedf eth prso nad co?sn I t’ndo gte teh opaapcrh ee!rh

someduck3  There was a question about this in Uworld. for *stubborn* patients who are "not ready to quit" just yet you use the motivational approach. The technique acronym is OARS: Open ended questions, Affirmation, Reflect, Summarize. +6  
yotsubato  Additionally the guy himself says "I know smoking is bad for me" Like he knows its bad, he doesnt care, but give him nicotine replacement and maybe he'll quit... +5  
usmleuser007  I didn't think nicotine replacement was a good answer choice b/c if he isn't ready to quit then why would he agree to use alternatives. +  
usmleuser007  People who smoke and are addicted like the feel of the cigs and environmental ques. Using replacements would be more challenging. The second best answer choice would have been Rx. +  
titanesxvi  why not detail the long-therm health effects of smoking? +  
seracen  @ titanesxvi: I assume because they always like the most "open ended" response. If you start detailing the long term effects, the patient might interpret that as attempting to convince, and might resist or feel pressured. By having the patient elucidate what they consider pros and cons, you allow it to be an open discussion. +  
suckitnbme  Also because the patient states he already knows smoking hurts him in the long run so it may come off as lecturing on something he already knows. I view this as what is the least-judgmental way to facilitate the patient moving on to the next step of the stages of change model largely of their own volition. +2  
usmlehulk  i choose the option c which is initiate a pulmunary function test. why is that a wrong choice? +2  
makinallkindzofgainz  @usmlehulk - he's asymptomatic, knows it is not good for him in the long run, but is not quite ready to make a change. It is best to talk with him about the pros/cons of cessation so that maybe he will make the decision to quit smoking soon. Ordering a pulmonary function test is not going to be useful. Let's say it's decreased. Ok, so what? It doesn't change management in this patient right now. +1  
rainlad  Think of it as motivational interviewing +1  
tulsigabbard  Still don't like the answer given that the patient already stated that he knows that it can do him harm in the long run. It seems like overkill. +3  


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I tpu iatconpnisot ebaseuc I hogttuh eht atnimdocie nbige sicdbreed mihgt eb C:BC acn esnooem plxeain why rteasitn ovre BCC?

seracen  Wouldn't nitrates be a faster acting drug here? That was my take-away anyway. One is more acute, the other for long term maintenance. +4  
suckitnbme  I also believe it's because CCBs have minimal effect on venous beds and would not cause a significant decrease on preload. +2  
beto  decrease of cardiac preload is another word of Venodilation, so Nitrates primarly venodilators. CCB dilate arteria more than veins +  
zevvyt  also, verapamil is the one that causes constipation. But Verampamil is non-dyhydropiridine, so it works more on the heart than the vessels +2  


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how doulw uoy rlue uot )C eeongin?amidibsyrf I ifrst eudsseg PAS but tsdwcehi ti buescae of eth /PTPTT gnthi

suckitnbme  You should be able to rule it out by the normal Thrombin time. Abnormal fibrinogen would have increased PT/PTT but also increased Thrombin time because the entire pathway is compromised by the inability of fibrinogen to be cleaved to functioning fibrin. +5