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Welcome to varunmehru’s page.
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 +0  (nbme21#14)
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The ohretm has monuauetmi roystdihtii and tartteenm is egniv orf hysdpoithroymi yo.ln hwy oesd it meattr fi teh emts'rho HTS is gihh ro wl?o eitAniobuosatd dlowu lsilt eb reenpst dan htye ludwo aawlys ecsua tsmceinir crsviieretpe of rothem oeomrhsn leelv. tsI'n ti?





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submitted by sugaplum(323),
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Tish iuonsqte si gasnik uatob JDV rataeerngmrne chwhi penhasp ni teh eobn arrwm.o hTe geesn era lla epdpoch up ebuaesc teh B ecll si rtyngi to ageeenrt a enqiuu nioobiamcnt rof sti etpocerr
lies pm cns.eot.cp. odd nwridgo

ephtCar 3 fo "how eht nemimu stsmey kw"ors - weemoas okob

varunmehru  in the question stem, they are asking about a constant region. VDJ rearrangement is for the variable. It doesn't make sense :( +3  
sallz  Both the constant (heavy chains) and the light chains undergo gene rearrangement. The heavy chain undergoes V(D)J random recombinations, while the light chain undergo VJ random recombinations. So gene rearrangement could work for both regions. +6  
azibird  The constant region does not undergo recombination. That's why it's called constant. It's just right next to the variable region though, so they get expressed together as one protein. That's why the constant-labeled DNA region is variable length here. +1  


submitted by sklawpirt(28),
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I htink het iade erhe si msilyp htat eon ludsho htkni bouat rewhe vilcsese are cmiogn rmfo no eirht yaw to teh ggloi mlcxoe.p

T"ow sspet dworrfa dan oen etps "ckba. yailSecplcf hte itqsenuo amy be rrinegefr to a erra crlaiciaafno ddosrre.i an saesnewras of htat sdeaies si ont nsresey.ac taWh si ynaceress is gnrnaundidset the gnoiir frmo eehwr eecsivls era idetacfrk ot eht glGoi srutpa.paa

OIPC nitpeor is eeendd to acto eslcves frmo eht RER ot nesd to g.glio Ts,hu tihw a outnamit ni ttah p,ioetrn the dgaeacpk toiespnr ttah luhsdo elbb ffo nad be tnes to teh ,oiglg isadnet uuacatmlec in the RRE nda lteiad it. hTus the w.anrse

p/ft09glw1/p4h/(Sm0l.2h/c:630/-w.9dje-p2cf17a02d.2)otws

hayayah  pg. 47 on FA got the good visuals! +5  
notadoctor  COPII* proteins are needed to coat vesicles from the RER to Golgi. "Two(COPII) steps forward; one(COPI) step back." Anterograde goes RER -> Golgi -> Lysosomes/Secretory Vesicles -> Plasma membrane +22  
titanesxvi  why not small lysosomes? +3  
varunmehru  and I thought large lysosomes due to lack of enzymes to degrade +  
samsam3711  The size of the lysosome is not affected by the presence or absence of protein, but its function is compromised (eg. protein is getting stuck in the RER) +  
fattyacid  I hope this helps to whomever was lost like me Null mutation: A mutation (a change) in a gene that leads to its not being transcribed into RNA and/or translated into a functional protein product. For example, a null mutation in a gene that usually encodes a specific enzyme leads to the production of a nonfunctional enzyme or no enzyme at all. +2  
pingra  I think you made a typo: COPII (RER -> cis-Golgi); COPI (trans-golgi -> cis-golgi and cis-golgi -> RER), clathrin (endocytosis and trans-golgi -> lysosome) +  
kevin  So my thought process was if there is no COP signal then instead of going to Golgi it would be sent astray into cytoplasm, akin to how in I-cell Dx the enzymes get sent out of the cell since there is no trafficking signal (therefore I presumed large lysosome due to eating the aggregated protein). Are we saying without COP or Clathrin that the vesicle will simply stay put where it is? If I can get a reply before my exam (2 weeks) that'd be much appreciated +