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Welcome to wolvarien’s page.
Contributor score: -1


Comments ...

 -1  (step2ck_form7#3)

Ok, the idea is simple, Celecoxib is a selective COX2 inhibitor that acts only to reduce pain, while indomethacin is a non-selective cox inhibitor which beside reducing pain it also reduce neutrophil chemotaxis, thus reducing the inflammation and tissue damage in an acute attack. This is the trick in this questions+

Aspirin act as anti inflammatory only in high doses.+

Allopurinol used to chronically to reduce future attacks be reducing uric acid+

Dexamethasone is a 2nd line drug used when there is contraindications to NASID+


 -1  (step2ck_form7#3)

Ok, the idea is simple, Celecoxib is a selective COX2 inhibitor that acts only to reduce pain, while indomethacin is a non-selective cox inhibitor which beside reducing pain it also reduce neutrophil chemotaxis, thus reducing the inflammation and tissue damage in an acute attack. This is the trick in this questions+

Aspirin act as anti inflammatory only in high doses.+

Allopurinol used to chronically to reduce future attacks be reducing uric acid+

Dexamethasone is a 2nd line drug used when there is contraindications to NASID+


 +0  (free120#20)
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Nvere tlel any ettianp to apy oenmy or to do nanghity ot so htta teh aopthsil or het orcodt etg p.adi tahT rskiste otu icchseo A a&m;p ,E

rveNe ryt to ascm hte inesranuc thwi elasf fingdsni saeuebc oyu wlli eafc lgela sicsunprose. Thta etrsisk otu ccehoi D.

oIgmnnrif teh ensniracu nmcpyoa tuoab hte et'psniat gohhttus or ohirveba iwll achbre the iyapvrc of eth p.ettian tahT kiserts out ehocic C.

ehT ynol aoliglc hitgn is to oiyltelp pxlinae ot eht enaptit atth oyu anc ont lycmpo tihw hre q.etures


 -2  (nbme21#28)
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the awy I huotthg abuot it, is ahtt eht snseoteesiOg mrIpetcefa srtesul ni efceevdit doiesto uctnooripd ihhcw si a rnoyesdac srrettucu ot eglloanc essnhtyis


 +1  (nbme22#20)
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I am inygtr to irufge hsti uto rfom eht nskil vp.iedrod aCn eonmseo eaepsl lenxaip eht loaarnti ehbndi ihst oqntieus ?

p4p4y4  I believe it's that this muscle everts the foot + runs over the lateral malleolus .. But the phrasing on the question is odd +4
angelaq11  I didn't actually know this one. I just ruled out everything except the fibularis muscles, and then to be quite honest, I think I had never heard before of the tertius one, so...I chose brevis. +6
asharm10  @angelaq11 same here :D +

 +0  (nbme22#29)
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I vaeh eadnrews thsi onituesq thiw itsh ohetehd tm CT is siwngho a mass on hte an dplxpefeti si no teh hgtri os tsih ihceco is Cmonguc wrea si on eth gthri os hsit ecicoh is otrsawochngm is no eht imeldd os tshi oeicch is ouwun edgnmrdo eusttcssuinpnoi erevn ehrda of tsi o eht ylon ightn eltf si nuJemuj





Subcomments ...

submitted by yotsubato(966),

This one made no sense. Celecoxib is already the strongest NSAID. I would rather give Dexamethasone. Which works along a seperate mechanism of action.

jaypat  Indomethacin is typically the first choice NSAID for acute gout flares. Then glucocorticoids. Lastly Colchicine +  
seagull  I also choose steroids since they were on a NSAID. fml +  
creamy  Naw dawg. Celecoxib has anti-inflammatory efficacy hence the categorization as a NSAID. In fact, gout patients treated with Celecoxib have the same treatment response as Indomethacin. Celecoxib is actually listed as an alternative to nonselective NSAIDs for acute gouty flares. This was just a bumbass question. +1  


submitted by lamhtu(113),
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iNgeden hrieg"h c"icnsonetontra of hte 6B fro zemyen vitytiac si haeonrt ywa fo iagnsy Km si gehrhi sienc reom si urridqee rfo 2/1 amxv .acviyitt rdeIncesa mK uvesal urstel ni 1K/m ingbe lsrmale eolcs(r to 0 no teh xa,-)sxi cwihh si dttomeenadrs in renwas hecioc .B

A nao""mrl znyeme yvittaic ni the enpsecre fo hhgeir 6B oracisnontcnet easmn taht xVma is otn gchiann,g tbu mK .is

d_holles  In other words, Normal enzyme activity = Vmax Adding more B6 to a mutated enzyme will improve it back to normal (Vmax stays constant, so Km will decreased due to ↑ affinity of the enzyme). +  


submitted by seagull(1403),
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tuo fo ,troiyscui owh amy ppeloe eknw h?sti o(ntd eb ysh ot asy uoy ddi ro ?idndt)

My rpeoyvt etoidacun dnid't inringa hsti ni m.e

johnthurtjr  I did not +1  
nlkrueger  i did not lol +  
ht3  you're definitely not alone lol +  
yotsubato  no idea +  
yotsubato  And its not in FA, so fuck it IMO +1  
niboonsh  i didnt +  
imnotarobotbut  Nope +  
epr94  did not +  
link981  I guessed it because the names sounded similar :D +14  
d_holles  i did not +  
yb_26  I also guessed because both words start with "glu"))) +27  
impostersyndromel1000  same as person above me. also bc arginine carbamoyl phosphate and nag are all related through urea cycle. +1  
jaxx  Not a clue. This was so random. +  
ls3076  no way +  
hyperfukus  no clue +  
mkreamy  this made me feel a lot better. also, no fucking clue +1  
amirmullick3  My immediate thought after reading this was "why would i know this and how does this make me a better doctor?" +7  
mrglass  Generally speaking Glutamine is often used to aminate things. Think brain nitrogen metabolism. You know that F-6-P isn't an amine, and that Glucosamine is, so Glutamine isn't an unrealistic guess. +4  
djtallahassee  yea, I mature 30k anki cards to see this bs +4  
taediggity  I literally shouted wtf in quiet library at this question. +1  
bend_nbme_over  Lol def didn't know it. Looks like I'm not going to be a competent doctor because I don't know the hexosamine pathway lol +21  
drschmoctor  Is it biochemistry? Then I do not know it. +4  
snoochi95  hell no brother +  
roro17  I didn’t +  
bodanese  I did not +  
hatethisshit  nope +  
jesusisking  I Ctrl+F'd glucosamine in FA and it's not even there lol +  
batmane  i definitely guessed, for some reason got it down to arginine and glutamine +1  
waterloo  Nope. +  
monique  I did not +  
issamd1221  didnt +  
baja_blast  Narrowed it down to Arginine and Glutamine figuring the Nitrogen would have to come from one of these two but of course I picked the wrong one. Classic. +1  
amy  +1 no idea! +  
mumenrider4ever  Had no idea what glucosamine was +  
feeeeeever  Ahhh yes the classic Glucosamine from fructose 6-phosphate question....Missed this question harder than the Misoprostol missed swing +1  
surfacegomd  no clue +  
schep  no idea. i could only safely eliminate carbamoyl phosphate because that's urea cycle +  
kernicteruscandycorn  NOPE! +  
chediakhigashi  nurp +  
kidokick  just adding in to say, nope. +  
flvent2120  Lol I didn't either. I think this is just critical thinking though. The amine has to come from somewhere. Glutamine/glutamate is known to transfer amines at the least +1