invite friends ⋅ share email twitter ⋅ join discord whatsapp(2ck)
support the site ⋅ become a member ⋅ unscramble the egg
free120  nbme24  nbme23  nbme22  nbme21  nbme20  nbme19  nbme18  nbme17  nbme16  nbme15  nbme13 
Welcome to wowo’s page.
Contributor score: 29


Comments ...




Subcomments ...

submitted by ashmash(1),
unscramble the site ⋅ become a member ($35/month)

yWh act’n we meuass atht het pitenta thwi an vltaeeed cretdi ubrbniili sdeo not ahev emos ostr of otrscnbuito weerh het eillaakn tahashpespo owldu eb adtveeel or( veen bdinu sjnonho en)yro?dsm I tidd’n ntkhi of rilbetG saesied ptiedes eth ieentttirmtn csuroe uebecas I dtne to oklo at ietcrd dna atolt librbiiun veells frist to see if hte tecidr nirublibi si eaelvted whchi in htis saec was lteeade.v

benwhite_dotcom  Few things. History always comes first. She also has even more indirect bili than direct. There’s also no other indication of obstruction clinically (such as pruritis), and you can’t infer an elevated lab value (alk phos) and rely on that in order to have everything come together. They have to give it to you. +6  
morelife  I saw this question on Gilbert’s and also put down increased ALP. I noticed the relapsing-remitting history. However, my thoughts were that a direct bilirubinemia is a false finding in Gilberts (since it is due to lower UDP enzyme activity), and would more likely indicate obstruction. As you said, you would consciously neglect this finding in favor of the history? For these specific NBME style questions -- you know, the wishy/washy ones -- would you follow the principle of “history first”? +  
benwhite_dotcom  @morelife, Plethora of evidence first. Here everything points in one direction except one small detail. If you were to make a list of pro/cons for each diagnosis using history, physical and objective data (labs, imaging, etc), the scales usually tip firmly in one direction. +1  
wowo  also, unless I'm mistaken, it's not a direct bilirubinemia - tbili is 3 and direct is 1, so unconjugated is 2. They're both elevated. Even with a decrease in function of the enzyme, it still works, so if unconj bili increases, you'll get somewhat of an increase of conjugated bili +  
kindcomet  @wowo, that makes sense if the unconj bili is due to hemolysis but it doesn't make sense if pathophys is literally the conjugation step. I would have expected DECREASED conjugated bili, if anything. +  


submitted by xxabi(228),
unscramble the site ⋅ become a member ($35/month)

NE is ervtconed to EIP avi TNPM, iwhhc is nciddeu yb tscol.iro

wowo  FA2019 p83 +2  


submitted by lsmarshall(371),
unscramble the site ⋅ become a member ($35/month)

Uear lcyCe Dsrseirod &;tg etdasIlo eesvre ahmoianmyrpmee (;gt& 10;00 i..e, on etroh erseve cmtolaibe bdacetisnsru

enhniitOr ayrtasslmbcrnaea nyccifdeei ;gt& t(osm ommocn ruae ylcce )di.s ctrioo /mdaaaaeiiuidcric, eaieoymmahrnpm

agcnrOi diAsecima ;t&g mreHeya,ioamnmp goai-annp dasi,ocis oisetsk (fmro cgyhayiope)lm

nimeuadc-hiM acyoCl-A egnoedsadhyre idcyefecni &t;g mmampi,yeeronHa teptyoohick ieyaohmpgycl ne(es ni i-βatonoixd eisoddrsr, PECTEX dputeosdohaeryroy)nlk

eivrL fydtoiunncs tg;& p,eHmamnmiyareo FsLT smsede p,u dlore .tp

lsmarshall  Summary of metabolic issues relating to hyperammonemia +6  
seagull  i'm leaning towards Ornithine transcarbamylase deficiency. +3  
notadoctor  Not sure why this isn't considered a mitochondrial disorder since the issue is Ornithine transcarbamylase deficiency in the mitochondria? +2  
charcot_bouchard  if it was mitochondrial disorder no one would escape +2  
wowo  figure in OTC deficiency, they might have to explicitly mention the orotic aciduria AND typically presents earlier, around 24-48hrs of life after they've fed (at least per BB) + also per BB, propionic acidemia and MM acidemia have an onset of weeks to months and lead to build up of organic acids --> acidemia in addition to hyperammonemia (not sure why, but several aa enter the TCA cycle via propionyl CoA --> methylmalonyl CoA --> succinyl CoA, but now this is defunct d/t enzyme deficiencies...?). Anywho, propionic acidemia described on FA2019 p85, but doesn't list hyperammonemia +2  
artist90  i think it cannot be Ornithine transcarbamylase deficiency bc it is XR disease. this pt has a healthy 2yr old brother which rules out X-linked recessive disease correct me if i m wrong +3  
artist90  it is 100% Propionic acidemia Uworld Q-id: 1340. it is an exact copy question of uworld. i got it wrong bc i forgot these are organic acids. But i am still confused on 2 things 1-how does acidosis cause Hypoglycemia and Ketosis. 2-why is Ammonia elevated in these pts bc urea cycle will be fine? +  
yb_26  1) hyperammonemia is seen in all urea cycle disorders except arginase deficiency 2) organic acids directly inhibit urea cycle => hyperammonemia (from UWorld) +1  
yex  According to UW, there is another question # 1341. This one refers to methylmalonic acidemia (ORGANIC ACIDEMIA). HYPOGLYCEMIA results from overall increased metabolic rate leading to increased glucose utilization and direct toxic (-) of gluconeogenesis by organic acids. The presence of hypoglycemia leads to increased free fatty acid metabolism that produces KETONES, resulting in a further anion gap met acidocis. Finally, organic acids also directly (-) the urea cycle, leading to HYPERAMMONEMIA. +9  


submitted by neonem(527),
unscramble the site ⋅ become a member ($35/month)

My btes eugss is htat tihs ieantpt sah a idibcsup trcioa vvela adn ash a umurrm ued to eirneacds vmloue oadrvloe omfr eht enrpnayg.c

charcot_bouchard  Can be congenital mild Tricuspid stenosis also. it also exaggerate during preg +  
wowo  probably just a flow murmur, https://acpinternist.org/weekly/archives/2017/05/16/3.htm +4  
noplanb  Wouldn't Tricuspid stenosis be a systolic murmur? +  
noplanb  I mean diastolic* +1  
centeno  I think that a murmur of grade 2/6 is a clue for flow murmur. Maybe any pathologic cause of murmur would be exaggerated in pregnancy (due to increased blood volume) +  


submitted by ameanolacid(23),
unscramble the site ⋅ become a member ($35/month)

toCnl'ud be SLA b/c eh dha royssen omevAtL.Svln.ne.i si lsicdntyit ynol .mroto Nto Slneygiiroyma hhicw( si urpep exeeitmrsit rneoyss hent otomr eatlr on) cb I udsasme yb hte iorwgnd ttah lal 4 eteimtiesrx reew vled.vnio Obv otn okasirnns,P dan tno ipolo cb agani, he ahs tomor + .sesyonr

sympathetikey  Probably in part due to early age presentation, but I hear you +3  
wowo  FA2019 p518 - process of elim for other spinal cord lesions +  
cbreland  Also syringomyelia wouldn't have a position sense issue +  


submitted by brethren_md(82),
unscramble the site ⋅ become a member ($35/month)

utrmo of liaenP anGld ()laniemoaP ssauce nirdaPua rnodSemy iect(rvla azeg ypsal)

neonem  Due to compression of the superior colliculus in the tectum, I believe +8  
wowo  FA2019 p516 +3  
misterdoctor69  FA2020 p528 +1  
qiss  tectum as in the superior colliculus +  


submitted by medskool123(24),
unscramble the site ⋅ become a member ($35/month)

anc oeosmen xpienal ywh isth is not tn?dunsractoi atLs enbm I iasd uoniacngjto adn got it gronw rfo s.taroctnn.uid this eon I yas turosacnntdi dna ist ouonct.jaing

pseudorosette  I would say because this happened between two bacteria, but in transduction what causes the acquisition of bacterial resistance is coming from a bacteriophage, which is a virus that infects bacteria, but that is never hinted at the question! +4  
medpsychosis  Quick Overview of the involved topics and answer choices that are relevant in this question: Transduction: Involves phage, cleaves DNA and takes a part with it as it is packaged. Generalized is when is happens by accident. Specialized is an excision event. Transformation: bacteria takes up naked DNA around it and incorporates it therefore becoming "transformed" e.g. (SHiN) S. Pneuma, H. Influenza type B, and Neisseria. Transposition: Jumping from one location to another within same bacterial organism (e.g. from chromosome to plasmid) Conjugation: Above mentioned plasmid gets transferred from conjugal bridge from one bacteria to another. +14  
wowo  FA2019 p130 +  
zbird  Easy here...first both are G-ves which likely have a sex pilus and if cultured together as in this case transfer their plasmid. Transduction need phage. Transposition is exchange of genetic material inside the bacteria b/n the dna and the plasmid or vv (FA2019) +  


submitted by yotsubato(841),
unscramble the site ⋅ become a member ($35/month)

Why si eht etpiatn tno ni ai.pn I lwtodnu peetxc daItecercnra nahrie ot tpnsere ihwt oezr p,nai utb 1 eekw of piionstontac and l.geiwlns

yotsubato  Incarcerated hernia. If the contents of the hernia become trapped in the weak point in the abdominal wall, it can obstruct the bowel, leading to severe pain, nausea, vomiting, and the inability to have a bowel movement or pass gas. Like really? Why is he not in pain? +1  
medschul  I thought that inguinal hernias were reducible? +  
fahmed14  could be a femoral hernia as they are more likely to cause incarceration. They do, however, present more often in females. (FA 2019- 364) +1  
wowo  incarcerated, not strangulated, thus no pain as there's no serious tissue damage/ischemia. Incarcerated hernias may progress to strangulated in which case he would have pain Under section, "complications" https://www.amboss.com/us/knowledge/Inguinal_hernia +5  


submitted by neonem(527),
unscramble the site ⋅ become a member ($35/month)

the dybo ssdrpeno to bodlo osls by poahtsoiems.ei isTh cruosc by gitaerupugnl arfernnsrti n(a noir aseoprrtrtn ni hte b,od)ol reiopotenrtihy opoicnudtr a( oomrehn adme lcseulixvye ni teh arnle uulrrtaebip raltienitist esl),lc adn ehme syte.ssnhi rtFis espt fo emhe syshnetsi was ataluylc aedludl to in thnraoe tinouseq on tshi se:tt esacntoidnon fo ygelicn nda nuciylcs CoA inot aita-evndlteme.aliulno This is r-itigemanlit step fo heem h.yntesiss

wowo  FA2019 p417 +1  


unscramble the site ⋅ become a member ($35/month)

nCa eosnemo nxpilea yhw the srawen tlc’odun be enhanaly?inpel

donutsnduodenums  The kid has albinism, which is due to decreased tyrosinase activity. If he has a problem metabolizing Phenylalanine, he would be presenting with the PKU sx like intellectual disability, musty body odor, etc., in addition to his fair complexion. +9  
zelderonmorningstar  I see, so if it was PKU he wouldn’t just be presenting for a routine examination. It would be one of those “oh crap what’s wrong with my baby” ones. +13  
wowo  FA2019 p83 +  
nbme4unme  Just a note that UWorld says phenylketonuria patients ALSO have albinism, it's just that the neuro sx and musty order are giveaways. +3  
pathogen7  Technically, albinism is a problem processing DOPA, and not tyrosine, no? I always associated "tyrosine processing defect" with ochronosis, which is why I didn't choose tyrosine. Guess I'm wrong. +2  
cmun777  @pathogen7 you're not wrong it is specifically DOPA but would any of the other answer choices make any sense over tyrosine? +4  
qiss  @pathogen7 also yes- you can't make DOPA because of a defective tyrosinase enzyme. This enzyme also metabolizes tyrosine into DOPA before it metabolizes DOPA https://www.google.com/search?q=tyrosinase&sxsrf=ALeKk021WaFQzRNr99BZVujxqRii-GzV6g:1585781210231&source=lnms&tbm=isch&sa=X&ved=2ahUKEwjzt-itp8joAhVDMqwKHUGYC3wQ_AUoAXoECBgQAw&biw=1280&bih=720#imgrc=MyxHLTV0gV7BKM +  
qiss  link fixed hopefully +1  


unscramble the site ⋅ become a member ($35/month)

heS sha esieOgontess pItece.armf akA lt“tieBr Bone zD” kaa aloCegln yTpe I eiynciefc.d U deen nlaegcol pety I ot mkea csrsa ia(lgnraotun ueists is tepy III dan thne aelopelomtsaster adn znci ccofoatrs phel sdteig itno teh imrf ptye I l).lneacog

wowo  FA 2019 p51 +  


submitted by stapes2big(10),
unscramble the site ⋅ become a member ($35/month)

m’I tno ersu taobu shti eon btu hte yaw I uhothgt oabut ti wsa thta csnie teh efondiencc nleriavt udledinc 1, it aws ton icinnsfaigt. nAd uths p elvau sutm eb eoabv .050

tea-cats-biscuits  That makes sense! +  
asapdoc  Had the same reasoning +12  
jkan  I get that it's not significant, but why is it 0.05<p<1 and not p>1.0 +9  
jkan  nvm, it's can't be greater than 1 because then it would have a negative% confidence interval which cannot happen (Think if p>0.05 means at least 95% within confidence interval) +9  
charcot_bouchard  p=0.05 means theres 5% chance null hypothesis is true. p=1 means theres 100% chance null hypothesis is true. >1 means >100% chance which isnt possible. +11  
wowo  p is a probability, so can't be greater than 1 +7  
noname  @charcot_bouchard, that is not a good interpretation of p-value. A better interpretation of p=0.05 would be: If in reality there is no increase in risk (RR=1), and if we replicated the same study of the same sample size many different times, then we would expect to find a risk ratio of (X) only about 5% of the time. +2  


unscramble the site ⋅ become a member ($35/month)

Cna naoydby exnapil tsih en?o I put tedaepre ttses suebcae I smseadu na dye8a-lro-3 wnmao si an ualuuns eiadrpgmcho for sisph.iyl

m-ice  83 might seem an uncommon age, but we don't know for sure her sexual history. She only recently (8 months ago) started showing some signs of mild cognitive impairment. She has all these results implying that she has syphilis, so the most likely answer is that she has syphilis, so we should speak to her privately about her sexual history. The tests don't necessarily means she got syphilis very recently, it's possible she's had syphilis for a while and never got treated. +5  
mousie  I understand that she could possibly have syphilis but I also put repeat tests because I know there are a few things that can cause false positive VRDLs but if she also has a + RPR does this make a FP less likely? And also if she has mild cognitive impairment you still discuss with her not her daughter correct ...? +4  
m-ice  This definitely could be a false positive, but before we want to consider it to be a false positive, we should talk to the patient about it privately. Assuming that it's a false positive before asking the patient about it could delay treatment of her syphilis. There's a chance she didn't want to disclose her sexual history in front of her daughter or maybe she was embarrassed or didn't think it was important to mention. And you're absolutely right, she only has mild cognitive impairment, so we most definitely should talk to the patient alone without her daughter first. +3  
seagull  She has dementia. She doesn't have the capacity to determine her own care (23/20 MME). I feel the daughter should have the word on the care since Grandma likely doesn't have the capacity to understand her actions. +5  
sajaqua1  From what I remember, dementia is typically a combination of impaired memory *and* impaired thought processes. There is nothing to indicate that the patient has impaired thought processes, and the memory impairment is only mild. The patient can still reasonably said to be competent, and so her private information should be discussed with her alone. +11  
yotsubato  Elder care homes or elderly communities actually have a high rate of STDs. Turns out, when you put a bunch of divorced/widowed adults together in a community they have sex. +8  
yotsubato  Additionally, you should respect the privacy of a competent adult with "Mild memory" impairment. I know I could have mild memory impairment considering the crap I forget studying for step 1 +11  
drdoom  @seagull dementia ≠ absence of competence -- the two are separate concepts and have to be evaluated independently. see https://meshb.nlm.nih.gov/record/ui?ui=D003704 and https://meshb.nlm.nih.gov/record/ui?ui=D016743 +3  
wowo  also important to note, d) repeated tests is also incorrect as the microhemagglutination assay is a confirmatory treponemal test (along the same lines as FTA-ABS) https://www.uofmhealth.org/health-library/hw5839 +5  
sunshinesweetheart  also.... I think we can assume that "repeated tests" means repeat VRDL, not "additional tests to rule out false positives" +2