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NBME Free 120 Answers

free120/Block 1/Question#5 (reveal difficulty score)
A 24-year-old woman comes to the physician ...
Vascular endothelial growth factor ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—mamed(25)
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Formation of granulation tissue (Day 3-7 of healing): Fibroplasia leads to the synthesis and deposition of type III collagen. Growth factors (ie- VEGF) from fibroblasts and epithelial cells promote angiogenesis. (Credit- Amboss)

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submitted by โˆ—an1(114)
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"pink, soft, granular, edematous wound" describes granulation tissue, which appears around day 3 and last several weeks. At this time, there is also an abundance of fibroblasts, endothelial cells (which contribute to angiogenesis with up regulation of VEGF) and macrophages as well as keratinocytes.

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submitted by โˆ—bwdc(697)
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VEGF is a major tissue growth factor activated by injury, cytokine release (infection, inflammation) and hypoxia that promotes angiogenesis and also increases vascular permeability (hence the edema). This increased permeability aids in the movement of proteins and white blood cells to the site of injury.

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