This patient likely has some form of upper motor neuron lesion or disease - UMN lesions are characterized by weakness, increased deep tendon reflexes, and spastic paresis. Baclofen is a GABA-B agonist specific to the spinal cord, used ot treat muscle spasticity, dystonia, and MS. GABA-B is a G-protein coupled receptor coupled to Gi, so agonism of this receptor causes hyperpolarization of the neurons and decreased release of excitatory glutamate.
kevinstimulates K+ efflux (hyperpolarization) and inhibits Ca2+ influx (no vesicle release)+3
submitted by โneonem(629)
This patient likely has some form of upper motor neuron lesion or disease - UMN lesions are characterized by weakness, increased deep tendon reflexes, and spastic paresis. Baclofen is a GABA-B agonist specific to the spinal cord, used ot treat muscle spasticity, dystonia, and MS. GABA-B is a G-protein coupled receptor coupled to Gi, so agonism of this receptor causes hyperpolarization of the neurons and decreased release of excitatory glutamate.