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NBME 22 Answers

nbme22/Block 1/Question#16 (reveal difficulty score)
An Rh-negative woman, gravida 3, para 2, has ...
O, Rh-negative ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +11  upvote downvote
submitted by โˆ—usmleuser007(464)
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Mother is Rh-neg --> she will generate RH-antibodies 1) fetus affected by Anti-Rh if it is Rh-positive 2) even if O-Rh-Positive is given, then still mother's Rh-antibodies will attack transfused blood due to its cells containing Rh+ 3) therefore, O-Rh-negative is best

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makinallkindzofgainz  you're not wrong, but I think it's better to have put O-negative because that's the preferred type of RBC for transfusion unless you've type and crossed your patient +2
mtkilimanjaro  I think fetus is O+ but if you give them that the RBCs will still be destroyed. You want to give O- as it wont get destroyed and wont affect the fetus in any way. Similar mechanism to giving platelets to someone with TTP, HUS, etc. they just get destroyed so its useless +1
tylerwill33  In utero, should give O- to avoid mom attacking again. After birth, O+ probably better. +1



 +5  upvote downvote
submitted by โˆ—keycompany(351)
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O, Rh-negative blood is the universal donor for blood plasma.

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keycompany  Edit:: Blood RBCs*** +5
peteralamir  I thought the O, Rh-negative blood was universal for Blood Cell transfuion, while AB, Rh-Positive was the universal for blood plasma (Since it lacks Ab to A,B, and Rh+ cells) +



 -1  upvote downvote
submitted by โˆ—humble_station(85)
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The mother is Rh - & fetus is Rh +

pg 397 FA 2019 Administration of anti-D IgG to Rh - pregnant mother during 3rd trimester & early postpartum period (if fetus Rh+)

Prevents maternal anti-D IgG production

anti-D IgG = O, Rh -

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snripper  Not sure why you're getting downvoted, but this makes sense to me. Maybe because you're claiming that the fetus is Rh+ when it's not clearly stated? But take that away and your explanation still makes sense. +2
j000  the question is not asking what to give to the mother. it's asking what to give to the fetus. +3
kani  is the baby not having hemolytic reaction. thats what i thought was happining. and you give a blood type the same as the baby. +



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