alnadiMen ncesG:ite
anM has 3/2 ncecha fo benig a icarrr.e (eH dose ton vhae hte das.se)ie no maW errirac rksi umts eb taludlacce itwh 2p^ + 2qp + ^q.2 ^q 2 = /10,4000 q = /21,00 p is uylhrgo = 21qp = 10/01 = Carrire cqurfynee .
ksiR of ahignv a ilchd stuh aeusql 23/ x /0110 x 14/ = 1006/e3eBs:a u c/2 = naM irrerCa kirs / 0011 = lmeeFa arCirer i 4sR1/k = hecCan yeht hcae ssap no het seresivec gnee ot iterh fpnosgf.ir
hTis the asme as pcy@a'nkyseom taainxeonlp iwth emor lnxaonepait oehst ttha eend ..i.t
ehT tneatip is ffadcetnue by eth altrcrupai uolaosmta ersescvie isesaed nda ihs trbrohe sah eht aauolmtos seesecvri adesise &;-gt- shit msnae eahc fo ehitr enrptsa raecrsi eth RA ll.laee ,owN rof eht enaptti ot eb ueanctdeff gnvei thta hbot hsi pntaser evha eth RA lellea, ti asnem hatt eth ittpnae hsa a 3/2 eanchc atht eh is tsumsyeliolnau nceftdfaue and a ecar.irr
heT t'ntaeips rptaern si eecuadfntf nda marlon eadybeirgnr-HW tsincege (sa dsetat ni het pobe.rwlh)m.en htis si ieyilacpcslf nedoni,tem you are ot ssueam tath eht rpernat hsa a eirarcr ucqeyfenr orf teh RA lele,al hhwic laequ ot p.q2
heT edseisa ash a yucqrfnee in teh otapnpoiul of 0.010/40 shiT is ^2q ;t&g-- q2^ = 40/.0100 nSlovig fro q, you egt q = 120.0/
reraCir rfeeuycnq is q.p2 veowerH, fro a arre aedssie, 2qp ≈ .q2 o,S eth eirarrc ucrenfyeq rof hte nrtprae = q2 = 2 * 12/00 = 011.0/
,owN eth Q asks uabto an ffogrsinp of eht etnapti and his arnterp eibng atefdefc, so ot hvae na fetdafce lhc,di hrete is a 41/ ncaech of ghaniv na efdtcaef ldich sbces(uea teh nettpai and the ntrerpa btoh haev a 2/1 cenhca of sgiasnp the lealle g-;&t- you itmlpelu htees ortgteeh 21/ * 1)/2.
S,o yliptulm /23 * /0101 * 4/1 = 1.600/ hsTi is ti(Pnptae gbeni a crarr)ei * e(pratnPr neibg a re)acrir * Phna(vig an dafftcee goiprfnfs ge)or.ehtt
heT yabiobtpilr of het afrhet begni a riacerr is /23 inesc it is nwkon that he sotd’en eahv eht ei.adsse neTh hte rbpbliiotay of imh spsangi ti on ot sih ikd i:s
/12 * 23/ = 31/
hWti hte riygrWdneea-Hb Pncripie,l uoy nac uegfri out teh iltpabryiob fo teh rotehm ngbie a arr:ceri
q = 0)1/,0q(r4s00t = 1020/
,So 2qp = 2 * 0/021 * 02/9091
, hcihw xoaprp is 001/,1 and eht iblyarbtoip fo eth dcilh gtentig hist lleeal si 01/10 * /12 = 1002/
T:hus
00/21 * /13 = 01/60
ywh htree si rtpioaiyblb fo rthfae ngbei a icerrar si 3/2
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49 65% OFFCctuiolsnala rof dad. eTh lbytprbiioa of eth fetahr bigen a crriera si 23/ ncsei ti si oknnw that he d’netos ahve teh aess.edi nheT het parobybiitl fo hmi ngsapsi ti no to shi idk is /2,1 thus:
nilCuaslacto rof mmo. ihtW teh r-iyWneaHredgb ii,lneprcP you anc ruigef tou het lrbipyoatbi of het mrehto ignbe a irrrc:ae
q = r00/1)(,0q0t4s = 00/12
So,
p2q = 2 * 02/01 * 1029/90
, cihhw is aorxpp 01/.01Fro het clihd to get the lelael mofr ,omm owt gshint eedn to hean:pp )1( mom usmt be a rcrirea zgyo]o[trht”“eee dna ()2 mmo mtsu sasp het eallle ot cild:h
gniPut ti lal rgotteeh. ,oNw eonbcim lla rt:geohte
= lbi(bipyorta of dad nigbe rrceria) * tp(yiirblbao of dda anpsgis on eseadis )lallee * (loyaitirbpb fo mmo nibeg rirac)er * i(brybtoplia fo omm isagpsn no deesasi lae)ell
=
2/3 * 12/ * 10/01 * 1/2
=
1 in 060
$279$49 65% OFF