iaadnnlMe :ntscieGe
naM has /23 ncehac of giben a ecir.rra e(H odes tno aveh hte e)aeiss.d Wna om crairer rski msut eb uadtccllea wtih 2p^ + q2p + .2^q 2^ q = ,0/04010 q = 01,2/0 p is hgourly = 2 p1q = 110/0 = airrreC rfuyecneq .
ikRs of nhgaiv a clhid htsu luqesa /23 x 0110/ x 14/ = 6/010/scBu3e :ae2 = Mna rraeiCr sikr 0110/ = amlFee arriCer 41skR/i = nCchae hyte ahce saps no teh reseivces egen ot terhi rpfnsgf.io
Tihs eth msae as @skepyma'ycon iapalennotx htiw orem ointaxaenpl shteo htta need .i..t
eTh eatntpi si ecnfdaeutf yb the altaprcuir osutlomaa creesvsie dsaeesi nad ihs hrtrobe hsa teh sotuloaam esercveis edessia tg&;-- siht maesn each of ehitr staprne aercsri eth AR lleal.e oNw, orf the inatetp ot eb nauectefdf genvi htat obht shi tsenpra evah teh RA aell,el ti neasm ahtt the ttepain hsa a 23/ ccehan thta he si mutsyeilnulsao afeufetdcn nda a iraecr.r
heT 'ptinatse entrarp si nteffduace nda mrolan iae-edrHgbynWr seecitng a(s statde ni hte brmewhn.eo)pl. ihst si fiepcllisyca mtdonneie, uoy rea ot sueasm taht eth eprrant ahs a eracrri qyerencuf rof hte RA a,leell chwih equal to qp2.
Teh eiasdse ahs a cefueqnyr in eht lnoiputpoa fo 1/000.04 iThs is q^2 -;&g-t ^q2 = /041.000 Snoivlg rfo ,q uoy gte q = 210.0/
rCirare cyeuferqn is 2pq. eoevrHw, orf a rera s,asedie p2q ≈ q.2 So, het iracrer enyqfuecr rfo teh nreprta = q2 = 2 * 100/2 = 01.01/
ow,N hte Q ssak tbaou an fpnsgfoir of teh tpntiae nad sih pnrater gbnie cedteffa, so ot vahe an tfcedfae icld,h reeht is a 1/4 nhccea fo hgiavn na edfcetfa dcihl seueasbc( eth naptiet dna hte rtnrpea bhot vhea a 21/ hcecna of pssagni eht ellale --;g&t yuo elumptil eetsh eethorgt 21/ * ./1)2
,So uptillym /32 * 110/0 * 41/ = 01/06. hsiT si (etPpnati ebgin a ica)rerr * (earPntpr geibn a )erirarc * (igvPnha na acfdteef ffngsopir tgtr)ehoe.
eTh brilayipobt fo teh erfhat eginb a reiarcr si 23/ esnci it si ownnk taht he ’eodtns heva het e.aidsse eTnh teh barbyolitip fo mih sgsnapi ti no ot sih dki si:
2/1 * 3/2 = /13
hitW hte WbeeindHarygr- prPin,liec oyu cna regiuf uto eth tbiyopiblra fo eht rhtoem iengb a iar:rrec
q = 0r,4s01()qt/00 = 2001/
,oS p2q = 2 * 10/02 * 900/219
, hwchi rpaxop is /,1001 dna the tlbayiborip of teh hlcdi getgnit hist eelall is 101/0 * 2/1 = /0012
uTs:h
0/021 * 31/ = 1006/
why treeh si rylbiiobpta of ertahf negib a rearrci si /32
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49 65% OFFtslciuCnlaoa fro dda. Teh tipbbyolari fo hte fehtar geinb a rceriar is /23 insce ti si wknon htta eh oetn’ds vaeh eth aeedsi.s Tehn eht iplibtroaby fo him sinpags ti no to ish idk is 21,/ h:sut
lltiusacCano for mmo. tWhi the adHWe-yiregrbn r,cneiPipl ouy can girfue tou eht rtobiipylba fo het tohrem bngie a aic:rrre
q = 1(r,t004)qs00/ = 00/21
oS,
2pq = 2 * /1200 * 0120/99
, icwhh si porapx /0.011roF eht ldcih to teg the eallel ormf m,mo tow inshtg need to h:peanp )(1 omm mstu eb a acirrer ye“e]gtrztoh”[eo nda (2) omm tsum apss eth aellel ot d:ilhc
uniPgt ti lal teotgehr. woN, cneibom lla eth:oegrt
= lyiarpitb(bo of add gnibe iercrra) * pi(otyrlbbia fo add npaigss on iesdsae )aleell * iraplob(ityb fo mom ingbe ierrrca) * rl(iiatbpboy fo mmo aipgssn no esaeids eellal)
=
/23 * /12 * 0/011 * 2/1
=
1 ni 060
$279$49 65% OFF