horSt aeswnr: All ensge era snptree in htbo B adn T lscel, utb hyet regrraena and sxesrep ptrsorcee thta are eccpiifs to theri e.nigela hreiT rae neneepintdd JVD nsogeir for B lecl rrotecpe ingraneoet adn T cell rcoepetr raogen!neit Tsih kiwi tiraecl sedhs thigl no :ihts
t_o(bckn/nricl/Drel#nikirwoaeitgeaoh_e_:wJi/te..osmtsd/pp)cpeTVrii
I oot lagtilayrc desism s.hti. tub it si aylcautl so emipsl atht we are ssinmig het tfrose hrtuhog eth tsere l-e iW-h obht B dna T cslel dgueorn VDJ tanrna,eergemr the ,V ,D dna J esgen rea RFTIEDNFE NSEGE sdipete gineb gnzeiaord nad teeofrhre icdesifsal ni a iiamlsr ionsfha deu to iterh ehdsar ened ot erneetag sevired tcuutrsre.s To maek tsemtra ermo ncsfiog,un btoh esst of DJV ngese aer no hromomcose 41.
iTsh is ywh the NMBE ifsipeced ahtt they aer gntgagi HTE ESAM J IONRGE wichh is ahtt fo eht B llec oteprcer gnee J gnre,oi not eht T ecll peterorc eegn ebJ-at orngei se(e iwik t.lrieac) ehT B cell pertreoc eegn is otn rardrenaeg in a T l,elc if it w,as T secll wodlu hvae i!ndobtiesa
eTh ayw I tthoghu tobua stih iuteqons saw atth ni MM ehtre si a TON of absiinetdo inbge ,dema so hte DJV tsgemne is iegbn oknber /rnteueedaecplsrear/dg mnya imtse adn ahs nebe ednsothre ot .1k5.b As rof eth T ,selCl ttha gorein n’sti nbgie dsue (incse ethre si on cllnoa opsnxaien or lt)sconeei so ’sti lislt otg the ufll b6k ehgntl tehd.ocnuu
ileWh T elcls do eus het JVD obn,nomietacir het T lecl crtpeoer niscah aer tfeefdnri nsege mofr the B l'lesc vyeah dna gltih csnih.a Scein ethy sdeu a B clel oeriJg-n rep,ob eht T ll'esc andb wlli eb mcuh earlrg sa siht raea of sit NAD eth( B cell aheyv or hiltg hcian sne)ge ehav not neeb neeaardrrg -- ntsdaie tsi T llec tepocrre neesg vhea bene .reaegrnadr
o/7otbolu:l_l/ri.bn_/mnsemdo_hcoptrqrti1bze.2snpr/_xiwee_t_eq2/w/aat4ehnsueetm/smsed/npctwtpnseip
submitted by ∗sacredazn(101)
It can be re-accessed by making a purchase.
Purchase your membership here
$279$49 65% OFFhTe opencct si a evcltdoonu ywa fo siknag fi ouy enkw who JVD nrnemtaooicbi wo,srk wchhi is ttha ti is ayctulal na mepaelx of letirgan hte DNA fo eht T/B ycymeho.tpl
uSrnoteh lobt cu:nqeithe oS ehnw htye use a orbep naatgsi msoe neigor, dna uopitutgnt a zsei fo 5.1 bk ro 6 kb, hsit si telling you eth eizs fo eht NAD nfrtmaeg ni caeh ecll t(es’odn atterm fi tyhe yas J ebrop ro nnaottsc roengi p,beor tehy’re just snayig e’htery tngagtier omes ecutionedl nseceuqe unodf ni the Ig suc/lCToR bate cianh soucl ryetspleveci fro B/T selc).l
I htnki hte onuisgfnc ratp udloc eb inoerdwng woh yuo kwno herhwet ’eoryu pytarl hohrugt eeearanmrnrtg nar(sew cesicho B turh D) or if ti tsah’n cerroudc at lal tey ecocrtr( rsnwea). eHer, the cncopet si htta B lscel drunoeg )(JDV eegrarmratnne ni hte enbo ro,armw iwehl T lslce do ti ni eht mysu,ht dna ti lla phpnsea at oecn. oS a maaspl lcle in eth dloob iekl ni iteMllup oemyMal duwol hvea ullyf euenrgodn taominercboin, elwhi a T lcel in eht bodlo cduol rethie be uyfll cdtaduee (and eavh esiindfh VDJ bmoiar)ecotnni ro teuairmm n(’thsa desrtat J.V)D
cSine het T clel enge aws 6 bk and yteidlnfie gribeg thna hte 5.1 kb egn,e het T ecll ’tahsn oedgnunre nebcootrminia ye.t
$279$49 65% OFF