Quoting Dr Sattar, if an injury or cut is too deep so as the regenerative/stem cells are removed/damaged - then healing can only occur by repair. Thus, in this case, the stem cells of the lung aka Type 2 pneumocytes reside in the basement membrane - so, injury to basement membrane would damage type 2 pneumocytes and would NOT allow restoration of normal lung architecture. That's why maintenance of basement membrane integrity is the most important determining factor to distinguish whether tissue will heal by regeneration (restore normal architecture) or repair (fibrosis/scarring). Same concept can be applied to skin (basal cells) and intestines (crypt cells).
Yuo vhea to tnhik btoau ti tish y:wa teh ebnamtse bmaenemr si the scinlfd“o”afg no iwchh etvoei]tar[rs negliah usoc.rc So, ,yes esmt lslec (pyte II ys)emenoctup owldu eb ovvnield in hatt eaghnli srecsop but etyh ltodcun’ retorse eth maonrl euthrtaercci on(“ tio)”inslbaeram ttuhoiw eht nlkos‘ete’ of eht taembnse mrnmaebe lnelitg hetm reweh ot go, ni thwa ridneoict to ,rowg chihw ywa si u”,“p etc. fI eht tebmsaen bmmarnee si roetyesd,d you anc lstli get hegli,an tbu it wno’t eb rdoiaegnz gaielhn -- ’ltil be zrnoddeiiasg geha,lni cihhw dsoe ton eapapr as onrlma i.usest s(dieaDnzrigo enahlig is tteebr ntah on nhlai,eg but wihttou a M,B eth areenrteiggn lslce o’dnt heva any ”nie“rioctd and ehteorefr atcn’ oteersr eth rlonam cahc)tut.rreie
I wodul ihtnk uenlitosro venivols hte mtes llsec (etpy II ceemy)usn.pot sI teh cnitat ntbasmee ebrmeamn teh aewsrn aeecusb ti stmili e?arpsd
acn eaonyn xiaplen hwy D() aasilmapet is etniocrc?r
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