effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor
decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.
hougT isotunqe.
laleRc taht neetanimM s'az(elhemir udg)r si a DANM terRepco tAnoigtnas taht leshp trpneev ctycexiotxoit yb inoBkcgl 2C+a neytr. hatT's woh I merebrem .isht
a picture for better understanding https://2e.mindsmachine.com/asf04.02.html
^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources
NAMD oepsretcr ni iths seac are binge dseu for onlg temr enpniiaoottt ihntwi eht brina dan tou fo lla fo ehrte cochsei oyln htsi errctepo essu a+C
I pkcide AMND seacbue i’ts tum,atoryisl ubt si eetrh yna pdeere seoran for sh?it
uoY anc nwsrea yb seorcps of atilneinmo.i teiie"povmtC re"aiotisntcn easmk you nihkt uatsltiyrmo T.N rssCo uto GABA nad geln.iyc In teh ctorxe os uama.lgtet oaMporcittbe oudlw eman 'sherte sonedc srmseneges dleivnov adn the erpteroc ouwdl otn tantrmsi imc.lauc nceeH NDM.A
deus in nolg mter tiontpioeant ,(genlaaug eom,ry)m ayM saol yalp a relo ni egne riciasonpttrn in roensun
)1 MDNA si a muattGeal rreotecp epu2t) bsy PAAM si a ysutebp of ADMN atht is ntiliilay taaevtidc by aamttlueg e3e )seral AMND cesreoprt rea ofund rean MAAP setoecprr utb are otn icdvtaate by wol vselel of lmutagtae esleera due ot a gM oin ’‘nkblicgo eht hnal4n e)c qeerFnut Antoci patnoilet —&;gt olnsiuamitt of AAPM ;t&—g eopesizardl ospt antysipc nnerou gt&—; evgtaol enndetepd gM obklc fo NAMD toerprec vemoder 5) niuxlf of Ca guhhrot NDMA —g;t& sceaus neve moer MAAP ertospcre to eb sinedter noit eth rmnemabe NET(O: APMA si nsivesrepo ot aC dna eu)ta6)gm tal ecauBse heetr era moer ocrtrsepe ot pnesdor to i,t teh lcel si mroe oiersvpnse ot lmeatgtau
lla the orsthe a oomtnvnieiectp ecins ythe ahev pfcycis(eceipticsifi sdga,ln)i NAMD si het lyno vectn(hioleceesnen voitecieptm cr)opt,eer has a iagdnl eits nda ac , na dna .enhmec.g. eicmvtetpoi
submitted by ∗nwinkelmann(366)
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$279$49 65% OFFo,S fro eosm a,enros tnrintteusoermrsa is nmiesghot e'Iv WLAASY egldstrgu .tw.ih. ylpaobrb cueeabs I 'stanw gttahu it lwle so evrne llyrea nleeard ti, just eenrald ohnuge rfo erawthve .xaem I tsju fuond htis oob hutoghr CNBI dan its NASFCTTA!I 'Ist mrfo 0012 os thgim eb old, tub it aws ger.ta oYu acn cesarh rhgthou het bkoo dan fnid hte ptraesh.c I prttey uhcm jtsu tenw utrhgho lla fo the tsnmenetturoarir hrp.aect c/w/i1:Bk..l/oivsmwNhp.90Kwg7tbt.nn/o/bs9ohn
yM nami ayalme sGktwatuet-:aa = jrmoa xiotyetcar ntrmateeorurti.sn woT spyte of repseo1:cr) t ci,omrbeotpta tsmo of hwich ear eanprsypitc iG whcih saled to rdceseaed MADN reoecprt acyittiv nda ikrs of ,citxxiiocytitoe ro ptotinascpys qG pstrcreoe atht edla ot nceiaesr ,a+N ,+K dan ceaeddser ugaemttal ucsesa zaapleotniiodr adn sednairec +g+M tpnmlaesicde and MAND eprtcore iyattcvi dan ikrs of ocextiytti,cxoi dna )2 ctonoprioi cnealnsh cunnigdli NMDA dan AMkP/eaiAatn nel,anhsc ihcwh lal loalw inepfnscioc ctoina f,nulix tbu lony MDNA lwasol C++a fnlxiu n(da yoln in a laevtog nepedednt enmrna taefr fiuictnsef oazrioitpnleda ahs idepcasld hte irtnoibih g++M oin ni eth a.heln)cn
BAGA adn eynclig = tbhiorinyi srtoera.itrstmuenn 1) A-AGBA and ACGA-B = nciooiptro nnhacsel htta deal to lexuf fo lC,- nda ieeptsd htis nagcusi ilada,oopnieztr the erunno tslil syast ebwlo gersnit ant.oltiep -GAABA dingbni iets rof bueitabta,rrs odss,trie ,BAAG and rxtinociop = dsniei reop fo .lhecnan ABAGA- bnnidig iset of endzsaipozebnie = idosute of proe of neclan.h 2) eylinGc cnhenla is a ryev lmiairs -lC feulx haelncn. 3 ) BAGB-A si a tbrmopcatoei eclhnan atth veaaictts iG eigandl ot deesdraec MAPc cihhw atatevcsi flfuex K+ snealhnc nda btnisihi C++a xfiunl sncheanl daeglin ot eatproaiyrilphnoz.
cgieBoni namies = asemtclhonecai paieodmn (onocdaontiri fo body mtm,veneo er,wdra m,ioonitvat nrrmfo),teciene noeerppnehirni esle(p, usasnflewek, totnnaie,t edngefi ebavirh,o epnrpnheeii swt(loe notnractcineo ni )NC,S slup nsriooetn ,ese(pl sawlfsenk,eu ne,opisesrd ,tnayxie u)anaes adn ahsiimtne alsor,ua( titntn,oea lageyrl, ustsei aagmde, and yma enlefcuni lodob aibnr w.lof) olvyOis,ub all fo hsti is ni aidotndi to gdrnecriae rimanosnsnsetoriu and lg,hitf gtf,rhi dna htifg .nseoprse
ATP and thore epsinru = ticaytxreo srn,tnaoisism oerldeae-cs htiw retoh s-lmcmaeelulol n.sieoasntertmurtr deoensAni tsn'i aiclyasscll cirdneedso a tsnreeutarmonrit sceaube ti 'tsni oaedsrtd/esrlee ni a++C eetndnpde nena,rm utb vrdeied fmor TPA eberfo hgainv na ecoritxtay tati.eolnp
illncoceeAhyt = aojmr intrueasrormtnet edniovlv ni tosuiimsrenanorsn avi rsumniac and iniconict cpreerto.s
Peedipt srirtutesnantoerm = mconmlyo areeelsd sa tiprdppoee rregal crspserour atht era vedleca yb csicefip symeezn atht eewr in the meas erretatosmtnrniu clsviee onpu elreea.s vFei stpey = ubanit/gr seedpt,ip idoipo eisppet,d yirpuatti idts,ppe yamhthlpcoai enegirlas ohoems,rn dna htseo ton saf.eiidcsl amEpselx = esrrurpoc htta vgeis rise to bcuensast P ipashcpm(u,po tcroen,exo and GIT and esdlerae fmor amlls eteaimdr NPS C ibefrs atht tsmirant pnia dna remeeraptut nnmtoaforii, ruelpowf hsepoiy,tevn ihentbdii by pooiid ies,pt)edp knrinneuio ,A uoerpetdnpei ,K and etripdponuee m,amga adn oipoid edisppte cdlungnii pntal ikadaosll eilk( hp)eorimn, tchisenyt oiidop isev,veidrat nda ,nrpdoeihns yhoprndnis, adn pehklan.nesi In algrnee odpoii tdesppei rea setanpsresd ei..( saainelag msichan,m)e voedlvin in lemxocp esobrhavi eas(uxl naatti,octr ssvgvemr/gseiiabisseu eoi,ashbr)v dna imditlcaep gtohh(u ont ieed)nitivf in yriccptsiah isddserro.
aOvl,elr aetsetisumnrotrrn = ptye spet:y ola-lulsemmcle nsrramsettti nda reos,peuindtpe ehrwe ouesellmcsl-lam netistrmtars rea seatrf nad aiteemd iradp cntayspi raismnisnsto ei(.. grnanode SNS trl/ghgh/itffiigthf uqkic snsrpee),o erwhe sa psoetiepneurd gn(ola whit gbocioil asmnei nda omse almsl llomeecu )esttmatsnrri rae orwsle dan emdeiat ar,gauld rdpogenol r.moiensutsnonrasi
moSe uetp:rics he:hepuadr/tpe/ptt.rmmwnnaivbwos_/ofvutrtu.i/estorr/kedphwceanenoli_.uiesktd_m, rn4iesgfd86sbc1gea-d-tura0ap/0s4e/1Ri5f0baaeopn-rgfrti6m/r27cte-pgAGsburw.cc/spstni/2-034BaeTthlf-:e6ew3oau0o3t18/.rgo-eB9l2-eriPeb1iAhw13hd/pladr6, nad lw03.-/gaa1ee-u_h/t/5r5ed=dwx7/3ee-bbdUt-f;2s=lglnfifaer1iit1.tmsx89wat-rh/4s/agn6i0pad.-fee6hg1#ba-c:bwnlg&abe2p-od
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