effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor
decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.
gTouh qoieusn.t
lRcela taht ennmaietM sealrmi'zeh( u)rdg is a NAMD pcRortee aAgtsnnoti tath lsehp vrnpeet ytetotciicoxx by lkgicnBo a2C+ ytnre. tsTah' woh I ebmremre hi.st
a picture for better understanding https://2e.mindsmachine.com/asf04.02.html
^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources
DNMA tsrcerpeo in tshi sace aer bngie duse for olng tmre opntaienotit itihnw eht bnria dna uot fo lal fo rhtee icohesc yoln sith rpeceotr euss Ca+
I ciekdp MAND besaecu s’ti yas,tolutmri utb si erthe yan eedrep asrone rfo s?iht
ouY cna wanesr yb srcespo fo .oianlitimen pv"eeimoitCt cntoisn"tirae aeskm uyo hitnk mtiuatlyrso NT. Cossr uot ABGA nda lcnie.yg nI hte xortce so tl.maautge aoMeirbtcotp wdoul mnae 'hreset dsonce ngesrssmee vlodevni adn het erecoptr luowd ton nsmtirta c.mciula eHcne .ADMN
duse in nglo trme ntoaitiptneo nug(g,aela moy,e)rm ayM osal plya a erol ni egen poirrsctninat in nornues
)1 DMAN si a ateuGalmt trpeeocr upeb yt2s) MAPA si a pbtseyu fo NMAD thta is naiitllyi avtteidca by ltgtueama leeres)a3 AMND eetocrsrp ear fudno earn MAPA oecrsrtep tub era otn taiavedtc yb wlo sevlle fo agemlutta eeaslre ued ot a Mg ino co‘b’iklng teh nl4 e)ahcn ueerFqtn Acotni toilenpat ;>— atnmstliiuo fo AMPA ;t—g& rslieeopdza sotp tnspiyca nronue ;&tg— tageolv ntpdeneed Mg cblko of NADM oeptcrer vdeermo )5 lixfun of Ca gohrthu ANDM &—t;g usaces neev oemr PAMA cerstoper to eb setndeir onit the ramnmeeb :(OTEN MPAA si oiernssvpe ot Ca adn eaa)6mg)tult Beaecsu ethre are orme ertecrpso ot pondsre to ,it eht clle is rmoe ssnvprieoe ot umatagtel
lla hte tsoher a tnetcpevmoiino ecnis yeht ehav cyseicifipcs(piifcte )ilsng,da NADM is teh ylon (esevltconeinneceh ocevmiptiet re)orptce, ahs a dligna etis dan ca , an and ...gmenceh tevecmiptoi
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$279$49 65% OFFoS, rof smoe sen,oar saurrormsnteientt si ohntsmgei 'evI WYSLAA gdstugerl .h.ti.w bpyrobal bueecas I 'naswt agtthu ti lewl so veren ryllea dalneer t,i tujs earndel ueoghn rfo etaerwvh amex. I jstu dnfou thsi oob ohurgth IBCN adn sti AACITNSF!T tsI' ormf 1200 os ghtmi eb dol, tbu it was a.egrt Yuo anc esrahc guhhrot eht obok and ifnd eht chta.pser I ytprte chum jstu wetn hgthruo all fo eht reutsttnmnraiore ecta.hpr 7vt/sn1o/..ho/tmwpi.snBh0ngbb://wk9.9icwoKNl
yM amin ae tlt:mstwyGau-kaaae = mjora tixortceya aermetsorinnut.tr woT septy of pe ro1e):trsc pti,atcbrmeoo smto of wcihh aer icretnypaps iG hhwci easdl to ecardedes ANMD rptrcoee iiytcavt nda kris fo ootxttiexcyi,iic ro ispsactyontp Gq secperrto tath adle ot cinaerse +Na, K,+ and desdreeac aglttemua sasecu tioazraelndoip dna dincreesa g+M+ lnpseaimcetd adn AMND crorteep yiaivctt dna risk fo oottcxi,iiectyx nda 2) oitpoirnco hnacenls cgdilunni DAMN nad itkMPAaAa/en hcl,nenas hchiw all waoll coesipfninc taionc iu,nfxl tub only ANDM lsalow C++a xifnul dna( olyn in a agtvoel edtnedenp nmeran tafer nffscteuii noezaioliartpd has lcsdadipe eht rothbniii ++Mg nio in the cnlh.)nea
ABGA nad gneliyc = itbihynior trmietsturnr.eosan )1 BAAAG- nda CABGA- = cponritooi hclesnna atth alde ot lxeuf fo l-C, nda septedi ihts cugsnai zrdoi,oplineata teh nouren tllis tayss leowb tsgnrie ta.opnleit A-AABG bigndin seit ofr trbeatsirbau, toseds,ir ,AGBA adn conorxtpii = sinied epro of .hnaceln GAA-AB nibgdin seti of peaenbzisizdneo = eostudi fo erpo fo enn.alhc )2 lcGynie anenclh si a vyre silmrai Cl- fxeul hnlan.ec 3 ) ABB-GA si a becpooattrmi ahnncle tath taveicats Gi degilna ot adeeesdrc MPAc hwhic teavcsita lfexfu K+ anlnches and bniisith a+C+ xlufin naslnhec gandlei ot tairn.plroopizeyha
ecoBingi ismaen = aacecemhtinsol iandepmo nd(oonriacoti fo yobd mm,eeotnv rde,rwa ittomaio,nv ofctenire,r)nem nnhriepeonripe ee,l(sp we,skasenulf ean,ttntio edienfg iavbo,rhe ieepiprhnen lwe(ots nocroeatncnit in N,SC) splu nnoeitros ,epsle( kawuslsee,nf ,eeisprndos aeixt,ny uen)asa and menithsai ,(uasralo a,inoenttt gelayl,r ieusst ,gdamea nad amy felcenuin boodl inrba wl)fo. luvsyi,obO all fo hsti is in tionidad ot ecieargdnr ounsrnnmearoistis and lfti,gh tirgh,f dna ftgih ps.eosren
APT nda rtohe psnreui = taeyocirtx snionsm,isart oe-csledear tihw htoer lemu-eaollsclm .utennsrtrsrtmeiao iAdneenso tsin' ssllcialcay ndroecised a isaerroentnurttm besucae ti 'nsit roteseleda/resd in +a+C neddpneet ,narenm btu dedierv rofm APT eerofb ivnahg an extrayoict atnt.eliop
hncloeltiAyce = ramoj ttetmnoinrrarues lveodnvi in rnesinsarisnoomtu vai smanriuc dna nniioccit rreps.oetc
Ppediet sttsrneetroimnura = mlmocyno selrdeae as todpppiree gerral eprsrucrso thta rea declave yb iespcfic zmnsyee thta erwe in het same rreonnisrtttumae vceslie opnu a.eslree eFvi tepys = agr/binut spdepte,i ipdioo ,deeipspt trtuiapiy ,sppteid thoayiaplmch linaseerg rmoon,ehs adn ethso ton l.icdeassif psxEmeal = cuosrperr htta sgive rise ot tncseusab P psuap(cmhoip, xoren,toce adn ITG dna ledarese ofrm lsmla eradtime SPN C rbsfie ttha tmrtnasi pnai dna aeuetptmrer tonormn,aifi wlrpefuo eoyesvnp,tih hibdineit yb podioi t)eei,sppd rinunknoei ,A oreednpiutpe K, dna idouertepnpe gm,aam dna oiipdo eepsdpit nngldciiu tapln akoalisdl k(eli ehpn,moir) ynetiscth idpoio ie,vdatsvire dan dpoh,nniser py,hroidsnn dan i.eepansklhn nI argelne oodpii edesptip era earsnpsestd .(i.e nieaagals hen)mcmi,as dvvelion in lpeoxcm isohrbvae uleax(s tiaoct,rant rvsgeigsevm/iasuisebs eabri),sovh nda ipedciltma ohhgt(u ton tend)viieif in scpacirhyti ris.esdodr
lv,eOlra rmeonnrrseistttau = teyp spe:ty ecloslmaell-um enttmtrisrsa nda iepunsprt,odee rehew olmleassluc-eml rsitrntatems rea tsafre and amiedte dipra syancipt nstrosaiinsm ei.(. enrnagod SNS g/itlhhtf/ghffirtig ciukq ose)ns,epr hwere sa ieernepsodtup (gonla iwht ooblicig maiens adn omse smlla lemucloe r)rtemitastsn era welsro nad iadetme adu,rgal onreldgpo nnsto.eironrisausm
moeS ipuects:r s_td:ipkpdnu/wmrnoivet./ru.st/ktewempmre/hcurtldnfwtea.sviena_htouoibhepe_oa/r, 1usfptee6p4Afw-aapl1iuiB/-6hosntd.g1p2f7b/cn-epog90t/B-b/3:ddcsrr.narib-4raet/ae4gluT0ess18/tmfeaaw2Pacdw1o033gee385Arcihgro/s-i-tr0eri6-r06h2GRebl, adn patg6ecwbx-eud3ae/.rn/et&/bhig.-b55_ao6l1a3;dr-ied:e9fwf8-s2d1e4-01rgg=m-taf/-h2la-Ubgtsani7/di1p#=xnethswwl/e.l0baf
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