effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor
decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.
ohTug u.qnostei
llcaRe atht aninMtmee zs(ei'emlhar ur)dg si a ANDM teeocpRr onitaAtsng tath plhse veptrne tooycxetcitix by iloBkngc aC+2 ntrye. T'ahts hwo I rebeemmr s.iht
a picture for better understanding https://2e.mindsmachine.com/asf04.02.html
^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources
AMND otesrcrpe ni itsh csae rea ngbie sdue ofr nolg etrm eoatinpiotnt ithwni the nbari nda uto fo lal of ether ohiecsc nylo siht trpeoerc sesu C+a
I cpdeki DANM bcsaeeu t’si romyutatls,i tub si rehet nya eredep soerna orf ?this
Yuo cna asnwer yb ssepcro fo lntniami.eio ivtoetipeCm" nittnacs"ieor aeskm yuo hktin royitulatms TN. srCso tuo AGAB and egcyl.in nI the cxrteo os l.eamauttg tobctMoapier ldouw aemn seter'h csnode gsnesrmsee vvinoeld and eth crptroee ldouw not tnrasitm ui.mccal ceHne AND.M
sedu in glon ermt ianpootetitn (luanaeg,g eyr)m,om yaM laos alpy a reol in gene rnanittpirosc in rnsneuo
)1 MADN si a tmtaleGau crrtpoee bt2)yes up AMAP is a yutbpse fo MDNA tath si lynliaiti aivceatdt by getaamtul 3a)eerls e ANDM trrseopec ear undof rean AAPM rcrtsoeep ubt are nto aciatedtv yb low elvsle fo lagemtuta elresae eud to a Mg oin kgl’bic‘on teh nac n)h4el nreteuFq cnotiA tplatione —tg&; nmtisltauoi of AAPM g;&—t pederzaolsi ospt cstpaiyn rnoeun &—;gt glvtoea etednpedn gM ckbol fo MDNA oerrptce emrvdoe ) 5 fiunxl fo aC hrgutho DNAM —t;g& cssaeu eenv mroe AMPA oerrtcsep to eb tisndree tion eht bameenmr T:OE(N APMA is eonispsevr ot aC and l6gum)a )taet caBeuse htere aer eorm reptroecs to rsodpen to t,i het lcle si rmeo rnvesoiesp ot aeagmtult
lla eth tosrhe a npoettoimvcein nisce ythe avhe siecfsciepcif(ctpiyi )glnsd,ai NMDA si teh nloy eecv(soenceinelnth pemovcteiit ee,)rporct has a aglndi seit dna ca , an dan e.mce.hgn. epicmtvetoi
submitted by ∗nwinkelmann(366)
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$279$49 65% OFFS,o fro omse s,rnoea nrrnieustsoremtta is nohstgeim 'eIv AWSAYL ggdserltu it..wh. lpabrboy saeceub I 'wtnsa utghta it wlle os erven aellyr aleedrn ,it juts rnaldee ohueng orf avweterh ae.mx I stuj odunf stih boo thugohr IBNC adn tsi AATSTF!NCI Ist' ormf 1020 os mitgh eb ,dol ubt it swa ragte. uYo anc ecahrs ohtruhg hte obok dna ifnd eth crahe.tps I tptyer muhc jsut tenw hurtogh all of hte tnreumrtanisrteo tahpcer. m./t.n:i.vBolwws9hbkcinoNs1og//t.bpK0w/h79/n
My main t- aGtetausaylwamea:k = moarj toyxraiect suirmeanet.rntort Tow yepts of ) tcp1seore:r epto,iobtacrm tsom fo wchhi ear inyscetrapp iG ichwh sdael ot eecsaeddr ADNM eepotrcr vaitiytc dna kisr of ,ctxiixotiotycie ro acpsiopytstn Gq rcpesreto htat dael to eiaerncs aN+, +K, dan caedresde tmetualga saucse przloaadniteoi nad resdnacie g++M tdspnaemilec and DNAM rperteco yivittac adn sirk fo icieoiyxtcxott, nda 2 ) ptiocnoior elsnchna cdinulgni AMND dna MeiaPa/tnAkA sae,cnhln wichh lal wloal inescnopcfi atonci lunxfi, tbu onyl ADMN lwlosa +Ca+ unflix a(nd lyno ni a tevoalg eepdtnden amnern tefra cuifftiesn zrlaanideoiotp ash eisldpadc eth toniirbih ++gM ion in the haenc.l)n
BGAA dna einclyg = otibhiinyr tnutsrnai.sermreto ) 1 AAGAB- adn CAGB-A = iocipoortn chnalesn htat leda to xfleu fo lC,- adn dtsieep stih nsaguci ozipltorda,iena eth oneunr tlsli tyass elwob nrsegit ntite.laop -BAGAA bidnnig iets ofr rbebuiaat,str sitrdeo,s ABG,A dan rnotoipxci = isendi oper of ahnlnce. A-GABA ingndbi seti fo einzisnpbeozaed = ietosdu fo erop fo ce.nalnh 2) eniylcG hlenanc si a revy lsairmi C-l lxfeu hl.ecnna 3 ) GAAB-B si a mctibortoepa calnnhe htta tvaitsace iG dniglae ot sadeedrce PMcA hihcw atcetsiva ulfefx +K snnhecla adn htinsbii +a+C xiunlf lshnance andelgi to oyr.ionphaepiarlzt
iBgoneic nmasei = catoesimlnheca dneamipo tircondaoni(o of dboy met,veonm wrare,d ,ntiomtiavo ern,nmfcero)tie ohnepirierpenn e,sep(l sunsalef,wke inoanett,t gdeinef hboeirva, hrppieennie lsoe(tw incatcetoronn in C)S,N uspl nstiornoe p(esel, ue,aswnkesfl doiern,seps texian,y )usanae adn nhsmteiai soa(,uarl ntani,etot y,aglrle sisute ,amgdea dan may cuelneinf doolb rbina wfl).o vObyo,suil all fo hsit si in niddioat ot gnreadiecr sitsiunarosrennmo nad iflh,gt htirfg, dna tghif ss.neorpe
ATP dan oreth neisurp = ytaicexort osmis,rnnisat l-aerecseod iwht ehtro csuo-lleammlle ermrsirtnuos.etnta osndeAien inst' ccayslialls eednircods a tirtremnstaroeun esubcae it tin's esededal/strroe ni aC++ enteedpnd mn,nrae btu revdied omfr ATP oerfeb navhig an trtaecxyio teaiot.nlp
Aoeycncilethl = omajr arotesrniterutnm ilveondv in nrossarniiutmoesn vai sarcmiun and oininctic t.seeprcor
epietPd ersanmnutertstiro = mcmnlyoo lsedeear as tideopppre agrerl usrorrpcse that are caveeld yb isecicpf eyensmz hatt ewer in eht mase trsteetnimrnraou sevciel unpo elsaere. viFe ptsye = taigrnub/ ppedtsie, dpioio ,ppseetid pttiiuyar tp,psied lpathomchyai niesaergl sro,monhe adn steoh ton laiissde.cf Eelxspma = uopesrcrr atht igsve seri to ucanestbs P hoc(pupams,pi rceo,oxetn dan GTI dna aerdesle orfm sallm traeiemd PSN C fsierb ttha stmnriat pain adn tumraprteee o,tmfanrniio fulworpe enei,ytpovhs iniedihtb yb iipodo tppi,e)des nriekonnui A, erdeenpputio ,K dna tpoireunpede maagm, adn odpioi seditppe ciiugndln aptnl aksaolldi el(ki ep)r,nomih csetnthyi iidoop dtr,iesvavei and priehns,ndo noi,shnrdyp nda ehka.neinslp In enraelg doopii peieptds aer pnsseaserdt (..ei eagasainl ncmsi,hae)m divnovle ni pmolcxe hisavboer axue(ls tiaont,ratc e/sgusvisrvbegiamsies eaibvhor),s and medciptail guht(oh otn deiv)ifitne in cyihaisptrc ssrdd.orei
,Oerlalv ntrrriaonemesutts = pyet esp:yt -aslluellceomm temrrtitasns dna prede,eiptsuno hreew ocmlla-sslmeleu attemnsirstr rae arstfe adn mtdeaei pradi tynapcis srtmoisnains e.(i. ngndreoa SNS hri/hfihgf/tfgtgitl iucqk sreospe),n wehre as etueosinperpd nlo(ga hwti ogiilcob anemis nda moes almsl ocleuelm amtess)rritnt rae elorws adn eatdmei ,laargdu ledoropng nnuinoseisamtr.sor
oSem ipc:restu tdltvdrneftshu/:swd/woesriaiir_ernpoeh.upneakikum./mahwert/pv_.pbtu_ncmtet/eoo, pie3n06f:6swptel-/bip.u0/66u054eaar/raaoaB9/7hc3Pa2heAro-d-4dep/rre0iwg-ea1fecsst0tAden-1s33d1cb2mgofh8Rgti.fc4blgg/ruprliasiw-/-Te8n2rGrBbo1t-s1et, dan tn=wafepliem-daa9ad1eih3-Ur/w6b#.es/.gfgd8ubbl/1shflrb6neb;t-/wd/p-g4ot2-:r.ghx-2ex-d1-linf7e5i0wt=30ctsaae1e&aa_/5g
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