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NBME 24 Answers

nbme24/Block 1/Question#23 (reveal difficulty score)
A 50-year-old man comes to the physician ...
Generalized malabsorption ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +11  upvote downvote
submitted by โˆ—karljeon(140)
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A man with a Hx of EtOH dependence and chronic abd pain as well as X-ray findings of "calcifications in the mid-upper abdomen" is most likely referring to a chronic pancreatitis.

This leads to a lack of lipase secretion hence, pale, foul-smelling stools with oil droplets per pt Hx. This pt's pancreas also doesn't secrete other enzymes, such as amylases, proteases, nor trypsinogen (to activate other enzymes), so the answer is "generalized malabsorption".

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karljeon  p. 367 (FA 2018) +12
usmlecrasherss  pancreatic insufficiency FA 2019 p375 , +2
almondbreeze  FA 2019 p391 on chronic pancreatitis +
almondbreeze  UW: in chronic alcoholic pancreatitis, alcohol induced secretion of protein rich fluid precipitates in pancreatic duct--> forms ductal plugs that calcify +3



 +8  upvote downvote
submitted by โˆ—hungrybox(1277)
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(D) Portal hypertension: Portal hypertension is a complication of longstanding alcoholism, but it is not the cause of acute or chronic pancreatitis.

In acute pancreatitis, alcohol transiently increases pancreatic exocrine secretion and contraction of the sphincter of Oddi (the muscle regulating the flow of pancreatic juice through papilla of Vater).

This leads to activation of pancreatic enzymes and acute pancreatitis follows soon after.

In chronic pancreatitis (as in this patient), alcohol increases the protein concentration of pancreatic secretions, and this protein-rich pancreatic fluid can form ductal plugs.

Made this explanation in case any of you were dumb enough to think "pancreatitis โ†’ alcohol โ†’ portal hypertension" like me.

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hungrybox  oh my source was big robbins btw +
regularstudent  I was definitely dumb enough +4



 -6  upvote downvote
submitted by โˆ—linwanrun1357(17)
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F**K this question!

Know exactly what the disease is without knowing what the f**king "generalized malabsorption" means!!

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tiredofstudying  Hope your day got a little better after this +7
ineedhelpwitmed  generalized malabsorption = malabsorption, generally +



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