For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I ahve na esusi with hsti sqeuotin ihwch osla cfcntisol hwit WrUlo.d In reodr to eb rddgeade by esormeosopt hte selfidomd nroipet odlwu ende to eb rseentp in eht soyltco rof n.iuuaobtni It ti tlduemuccaa in hte RER neth who dose ti etg gde?tga loysHt,en os i.no.tclcf.ed
Teh TFRC erptoin si a mnasberraemnt ineotr.p ieLk lal rtes,poin sti irsnlottaan ebsign in teh oolc;yts atht i,asd CTFR nanitcos an rieusn-mNt lgs“ian e,ceq”senu ihchw msnea as it si niegb edtltrana,s it dna( the esmroibo animkg it)! liwl be anroeptrtsd ot teh iEanpdcmlso uui.^ecRlmtotooftn!e
sA ti gest d,snrtlaeat sit ryodopcbihh ftiosm lliw eeemg,r hihwc besmed hte RCFT onpitre thwnii the ilhdihpposop yblraie fo eth ER ef!tisl taTh snmae eth rnptioe illw veren ginaa be nfduo in“ eht lcostoy” eucabse ti gtes edhaterd urghtoh eth yblaire hiw(hc ,si in fca,t owh lla ensmnetarmrab oprtnsei oebmce mrtbnrasenmea iertposn ta hte lecl faursce -- hyet avhe ot eb edma inot bmnarrmestena eiptnsor ni eth RE !.)iftrs
,So ye,s tilelm,tayu tsehe slfdodmie oesrptni liwl eb terddcei rtwoda a omepsortea orf rndglteici/oen,cryadag btu ttha wlli ppeahn as a liltet eecsvil or( o”);“ilspmoe hte ieomdflds oprntei, in htis ecs,a is tno balwtoerl-esu sc,n(ie yb ,nieitndoif it has rhocdbpihoy itomsf chwih egt “drtedeha gt”ohhru a lbrieya to atrece eht narsmteanbrme )rpe,atnt hchwi easmn uoy own’t indf it ni the lo.scoty
\ oontet!of \ hTe ihtighnc fo iavce*t obmeosirs to the psdomalEnci ictlmuueR si hyw we lcal that raea of ER hg“oru ocpianEsmdl litemuuRc ”(RrE;) on terolenc iy,opscmrco htta oneicst swa cesekdlebp iwht leiltt t;sdo trlae, we mua()shn doedevsrci ttah ehset odts were msoos!bire
\ * \ By ceta“vi s”ms,ooribe I tjsu naem ermsiboos in eht orcspse of rgnctveoin ARNm to tnprieo! (aWht ew alcl ta“osnn”tialr );
rFo a eatrg ltltie ruamsmy of het dcpaElionms etuuilmRc n(da ymna hoter cstcnpeo in amlerluco libo,y)og! ees ihst rmfo rbs’elAt ulrclMaeo yioglBo of eth lleC:
wB4o40cnkvimps:2//2Nbho18ow#/6//bt2gtw.A.s.nKlhin.
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
When serintpo eginb aedm in hte ER oil,dmsf heyt acuactumel ni eht ,ER iwchh tneh gtesgrir mhet ot eb spti otu inot hte coosylt nda bmceeo edraegdd yb pssmoet.aore suh,T teh tlimucnauaco of eth dmlfeidos reopint in the ER is drriquee orf mhet to lytumielat be daegtg yb uutiiqinb nda be garedded ni mao.eostpres
Evne fi you egaru atht thye will be catcilgnumua in eth tylcsoo ceeubas eomrapsteos rae ni eth sotylc,o the utioqesn si nskagi wereh rea eth niorptse algmicacnuut, not iebgn redegdda. So ythe ta'nc etccmuuaal in st,oeaemopsr ueacbse hyet rea tyddseroe ni mt.eh
hTis is omfr m:aosbs detMuta TFRC gnee 850Δ(F m)ittuaon → deidlmfso iteopnr → eeectdvif tprnoie is ateernid in het uoghr ipocemsanld uerulimct R)E(r ofr aodtdaignre → PtTd-geaA ehdorcil cnnleha is nbseta no hte ecll recfuas of ieiethallp ecsll thuohugort het obdy .ge.(, telininsat dna pyaerorisrt ipheltae,i wseta angsl,d ncrexoie ac,rpesna eirecxno sndlga fo toduvercriep soga)nr
TLRAU ILP.SME
1r.hete rae nyma iavsanrt of cyctsi riiosbfs so hsit nsoteuqi si ton uoatb shtp.hyayp of CF
opin.t2 fo otqeunis : hrewe does erionpt ildnfog uoccr ? rews)an ERR
PTI : IF OYU EEKP RGNIERCSAHE NO ASVANTIR FO C,F YOU RAE NO A PHTA TO DSLEENS OMOD
plfu elhnfopibnX&ca=huc/cahyv.i3b:ysauGalgtQwlhtso/toew/jnmIopea=_y.;gmBewNt?uwHs
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$279$49 65% OFFI ikhtn mero elarln,yge oernpti lfdoing ppnshea ta the RER nad eth mtse ssay eth orntepi tnos’ed flod ylpo.prer ilSal,cpfeiyc eht tsom conmom FC mottniau is a ldmsifeod pieortn adn hte ntiroep si radetnie in eht RER adn otn endrorstapt to teh lcle eernmbam - AF 1920 gp 06.
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