For a great little summary of the Endoplasmic Reticulum (and many other concepts in molecular biology!), see this from Alberts’ Molecular Biology of the Cell: https://www.ncbi.nlm.nih.gov/books/NBK26841/#A2204
I aevh an essiu ihwt itsh sunteoiq chwih oasl tsnciocfl whti oUWrdl. nI rdeor to eb deedardg by ooesoetmsrp teh mddofiels enioptr wlodu dene ot be trpeesn in het ocosytl orf anu.nuitibo It ti ulctuaemcda ni teh RRE nteh who sode it get ?teagdg ,yHeslton os ni.e.c.ctldof
The CFRT rpetion is a rrmeamtbnesan oprni.te eLik lal epsitrno, tis rttsnoalnia gibnes in hte cyotso;l ahtt dias, CTFR cnotsain na unmNtseir- gasni“l ,esqu”ncee chhwi enasm as ti is nbegi dret,tnlaas ti (dan the eoirbosm ngaimk !)it illw eb narteptosrd ot the slonacmpdEi ^eicltu.muReot!fnoot
sA it segt ,elnrdatsat sti bcdprhohoiy ofmtsi lwli em,rege iwhhc embdes hte FRCT eorntip hnwtii teh dholispoipph eabylri fo het RE !ieltsf tTah anmes het tropnei illw veern gnaai eb onufd n“i the cyloots” sbecuea ti tsge therddea touhrhg hte alerybi chiw(h is, in ,catf who lal bmrntsnameare nopsiret beceom bnsnarmameert pinrsteo ta hte lcle rufeasc -- yhte evha to eb adme noit aeernmsarmtbn stinproe ni eht RE if.r!st)
So, ,eys iylttmauel, sheet odmsidlfe irsteopn liwl be dtdierce tdwrao a petseoroma rfo rrdgainyldetc,gaci/eon btu ahtt wlil aphepn as a teiltl cseievl (ro ”om)ls;ioe“p eht sdlimdefo reoitp,n in sith ca,es si tno e-lsblaowretu in,e(cs by tinndi,efoi it has opbhiyhcrod oiftms iwchh gte etrd“hdae tuh”hrgo a erlbaiy to recate teh eetnrmamsbanr tn,)rteap hciwh sanem yuo wnto’ dinf ti ni eht tsloco.y
\ o!tntoeof \ hTe igcnhiht of tvica*e obiomsers ot eth ascidmopnEl uliRmucte si wyh we alcl atht aaer fo RE guhor“ opndaEmlics tlRuuecim r()”R;E on cnolrtee y,scrioopcm atth snictoe asw ksedbceple hwti llteti ;dtso ta,erl ew nsha)u(m sceeidordv ahtt ehtes dost rwee r!osmiobse
\ * \ yB “vctaie seb,moso”ir I juts aemn mbsseooir in teh spceros of otcrenngvi RANm to petr!oin taW(h we alcl trt”nslnoaai“ );
orF a egatr elitlt ammuysr of teh npmsEdcoali leuiRmcut (dan nyam eorht stncocpe in rlmuecola g,ybool)!i ees htis rmof serl’Abt eralMlcuo ioloByg fo teh lelC:
n2w/ob.t4Bg/m/hp.8214h:nvt2o.owsc0kiisnbl6w/NA#/K.
A mini-discussion of protein transport within the cell is here: https://nbmeanswers.com/exam/nbme21/742#257
enhW rnpeitso bngei eadm ni het RE lsdmo,if ehyt eatumcaucl ni eth RE, cihwh hnet gsrietrg temh to eb ipts otu itno teh ylctsoo adn ebocme edgeddar yb emrpsoeoa.ts hu,Ts hte uaoalmcctiun of het sdflimdoe neoptri in hte RE si ueirqder ofr htem to lemytatlui be gegdta yb iqiuubtin nad eb edardedg ni somp.reotesa
venE if ouy eagru taht htey illw eb gitlmcnuacau ni hte oclyost eacsube aposoetmser are ni het s,tcoylo teh inetqsou is kiangs ehewr are eth oeisptrn mtaniuugclca, ont negib dderedag. So hyet cn'at tuelmucaac ni ssompteeo,ra ebcsaue heyt rea esortyded ni htm.e
hsiT si omrf sos:amb eaMdtut FRTC egne 0Δ8(F5 )aiutntmo → fmdsoledi renopti → vcefeidte netpori si taeniedr in eth roguh spdelmcaoni cmiluuret (ERr) rof odiaatgendr → dteP-gAaT lierohcd canhenl is enstba no the lecl afcuers of lhilepaite lscel oruhtoghut teh dboy e(..g, tniitanesl and rsirortaepy ilieha,pte sweta lndasg, oexcenir ,resacnap norixeec salngd fo pvceurotierd oa)rsng
RATUL L.EMPSI
1t.ehre rea anym vtasnrai of cctisy isrbosfi os this qoiestnu si nto oubta sathyp.hpy of FC
2tponi. fo esuqtnio : weerh odes neotirp lginodf occur ? asenw)r RRE
IPT : FI OYU EEPK SEICREHRAGN NO RSANVATI OF FC, OYU REA ON A HTAP OT SELNSDE MOOD
fu plelhua/jegnc.two:ct=yhpu?_wynmipwltslhovfHoe;wbgQesB=ni3t/mNGsXaoacIaub.&hay/
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$279$49 65% OFFI iktnh eorm nl,yaglree ioretnp inodlgf epnahsp ta hte ERR and het mste ayss the eprniot stdnoe’ dofl yp.roerpl leciafcpl,iSy eht osmt ocmnom CF muiottan is a dsfldeiom iponter and teh epnoitr is ndteiaer ni het ERR and otn nrpsrotetda ot hte lelc mrenmabe - AF 1902 pg .06
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