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NBME 15 Answers

nbme15/Block 2/Question#39

A 43-year-old man with a 10-year history of ...

Decreased glutathione

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submitted by ergogenic22(28),

NAPQI is a toxic intermediate is formed by in small amounts by metabolism of acetaminophen. Depletion of hepatic glutathione stores by NAPQI leads to acute APAP toxicity and acute liver injury.