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NBME 20 Answers

nbme20/Block 1/Question#16

A 30-year-old woman with multiple sclerosis comes ...


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submitted by strugglebus(69),

The pons has nerves 5-8, so the trigeminal would be affected here

masonkingcobra  Thalamic pain syndrome would involve dysesthesias on the entire contralateral body so more than just the face. Also it occurs often after post-stroke. Additoinally, these dysesthesias appear weeks/months later +2  

 +2  upvote downvote
submitted by sympathetikey(303),

Principle Sensory Nucleus of the Trigeminal is located in the Pons, as is the Motor Trigeminal Nucleus of the pons. This presentation is probably dealing more with the Principle Sensory Nucleus.

 +1  upvote downvote
submitted by whossayin(5),

The mnemonic I like for remembering the locations of the cranial nerves is the "2,2,4,4 rule"

Above brainstem= CN I + II Midbrain= CN III, IV Pons= CN V, VI, VII, VIII Medulla= CN IX, X, XI, XII

 +1  upvote downvote
submitted by feliperamirez(1),

I do understand that the principal nucleus of the trigeminal nerve is located at the pons. But since this patient is having trigeminal neuralgia wouldn't you be disrupting the pathway involved in pain and temperature, which in this case would be the spinal nucleus (located in the medulla)?

Besides, I found this at an article

A recent hypothesis attributes the pain of trigeminal neuralgia to a central mechanism involving the pars oralis of the spinal trigeminal nucleus.[5]


I also choose medulla, b/c this patient presented w/ pain, but not any abnormalities in sensation. Pain is mediated by spinal trigeminal nucleus located in Medulla, not Pons

+/- ssc505684708(0),

 +0  upvote downvote
submitted by woodenspooninmymouth(0),

MS is a demyelinating disease. That's why I didn't pick cortex or thalamus; they are grey matter. I picked medulla because I the spinotrigeminal nerves traverse the medulla. I guess we are just supposed to assume the demyelination is happening in the pons? I don't know.

woodenspooninmymouth  Sorry, I meant to say that the pons would have the cell bodies for the pain/temp neurons, no? +