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NBME 20 Answers

nbme20/Block 2/Question#6

An 18-year-old boy has just been diagnosed with ...

50%

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submitted by celeste(32),

While the lifetime risk in the general population is just below 1%, it is 6.5% in first-degree relatives of patients and it rises to more than 40% in monozygotic twins of affected people. Analyzing classic studies of the genetics of schizophrenia done as early as in 1930s, Fischer concludes that a concordance rate for psychosis of about 50% in monozygotic twins seems to be a realistic estimate, which is significantly higher than that in dizygotic twins of about 10–19% (ncbi.nlm.nih.gov/pmc/articles/PMC4623659/#ref3)

imnotarobotbut  How is one supposed to know this before having read this article? +3  
imgdoc  This question falls under the either you know it or you dont category. It isnt in FA or Uworld +  
jaxx  So why would these A-holes put it on there as if prepping for this exam isn't stressful enough :-| +  
doodimoodi  Lol just why seriously +  
champagnesupernova3  This was mentioned in the Kaplan behavioral videos +  




 +0  upvote downvote
submitted by babydoc(0),

Inheritance pattern is autosomal dominant. Patient has 50% chance of inheriting and if she does inherit it, she has about 100% of developing colon cancer. 0.5 x 1 = 0.5 thus, 50% chance.

babydoc  oops wrong Q +  
usmlephile  This one makes more sense and its pretty direct! +  
usmlephile  sorry wrong Qs +