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NBME 21 Answers

nbme21/Block 1/Question#18

A 61-year-old woman is brought to the physician by ...

Donepezil

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submitted by ergogenic22(42),

elderly lady with slow, progressive memory loss, normal physical exam, no signs of depression, this is most likely Alzheimer disease.

AChE inhibitors are used for treatment because Alzheimer's is associated with low ACh. Also used are NMDA receptor antagonist (memantine)





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submitted by step1soon(8),

During the Mental Mini State Exam (MMSE), a health professional asks a patient a series of questions designed to test a range of everyday mental skills. The maximum MMSE score is 30 points.

-20 to 24 suggests mild dementia -13 to 20 suggests moderate dementia -less than 12 indicates severe dementia.





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submitted by divya(1),

Currently Alzheimer's disease treatment includes -

1)Enhanced Ach transmission (Donepezil, Rivastigmine, Galantamine

2) Neuroprotection via antioxidants (Vitamin E)

3) NMDA receptor antagonism (Memantine)