NBME 21

nbme21/Block 3/Question#7

A 65-year-old man comes to the physician because of ...

DNA fragmentation

Login to comment/vote.

 +1  upvote downvote
submitted by feronie(1),

Orchiectomy = ↓ testosterone production = ↓ DHT => prostate cells undergo apoptosis. (This mechanism is similar to using 5α-reductase blockers to treat BPH.)

Apoptosis is characterized by DNA fragmentation (pyknosis, karyorrhexis, karyolysis).


 +0  upvote downvote
submitted by _pusheen_(0),

Alternatively, all the other options pointed to things that would actually increase testosterone production and its effects; orchiectomy would obviously not do that.


 +0  upvote downvote
submitted by cytocoins(0),

With the drop in testosterone (and therefore DHT), some of the prostate cells will undergo apoptosis. Apoptosis = DNA fragmentation (180 bp segments).