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Retired NBME 25 Answers

nbme25/Block 1/Question#10 (reveal difficulty score)
A fetus is exposed to an infection at 22 ...
Maternally transferred spirochetes replicating in fetal tissue ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—shak360(20)
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In these questions, we should recall the TORCH infections.

Congenital syphilis is caused by the maternal transfer of the spirochete Treponema pallidum through the placenta after the first trimester. It often results in stillbirth, or hydrops fetalis (which is also seen in Parvovirus B19) and presents with facial abnormalities (notches teeth, saddle nose, short maxilla), saber shins, and CN VIII impairment or deafness (which is also seen with Rubella, hearing loss is also seen in CMV).

The main symptoms linking it to Treponema pallidum are rhinitis, periorificial fissures, and dental malformations. Note that hearing loss, seizures, petechial rash, and intracranial calcifications can also be seen in CMV.

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