(FA 2021, Pg. 527)
This question is testing knowledge on the clinical reflexes, specifically the Achilles reflex.
One of the key things to pay attention to in the stem is that the patient has a left Achilles tendon reflex that is absent. The Achilles tendon reflex involves S1, S2 ("buckle my shoe").
This question is testing your knowledge on sarcoidosis.
It is not referenced in First Aid, but this is neurosarcoidosis. You can find a small amount of info on it in AMBOSS:
Sarcoidosis can present in many other areas besides the lungs which is the typical question stem we are all used to seeing. One thing to note about it, is that where ever it implants it will cause symptoms in that region (e.g., CSF -> meningitis).
(FA 2021, Pg. 416)
This question is testing your knowledge on neutrophils.
In the stem patient has a right hand that is tender, erythematous, and edematous with an intact wooden splinter embedded in the soft tissue. Then the description of "white exudate" is given. This white exudate is pus and is generated by neutrophils. Additionally, neutrophils are the first responders to most insults to the skin.
Another very important thing to know is the neutrophil chemotactic agents: C5a, IL-8, LTB4, 5-HETE (leukotriene precursor), kallikrein, platelet-activating factor, N-formylmethionine (bacterial proteins). Make sure you know this, the test makers love to test this!
This question is testing your knowledge on gout.
In the question stem the examiners are showing you a picture of a hand with extensive tophus formations (often these appear on the external ear, olecranon bursa, or Achilles tendon).
Strongest risk factor for acquiring gout is hyperuricemia, which can be caused by:
Treatment:
This question is testing your knowledge on microtubule inhibitors (all are M-phase specific).
Specifically, this question is asking you about Vinblastine. One important adverse effect to know about vinblastine (blasts the marrow): myelosuppression. Therefore, you would see a significant decrease in the numbers of neutrophils.
This question is testing your knowledge on T- and B-cell activation.
My specifically it is asking about B-cell activation and class switching. The following steps occur during this process, and step 4 is what you need to know in order to answer this question correctly:
1) Th-cell activation as above. 2) B-cell receptor–mediated endocytosis. 3) Exogenous antigen is presented on MHC II and recognized by TCR on Th cell. 4) CD40 receptor on B cell binds CD40 ligand (CD40L) on Th cell. 5) Th cells secrete cytokines that determine Ig class switching of B cells. 6) B cells are activated and produce IgM. They undergo class switching and affinity maturation.
This question is testing your knowledge on ovulation.
During ovulation there will be increased estrogen, increased GnRH receptors on the anterior pituitary. Estrogen will continue to rise and then eventually this will stimulate LH surge --> ovulation (rupture of follicle). Increased temperature will also occur and this is (progesterone induced).
Also, keep in mind that there are two phases of the ovarian cycle:
This is question is testing your knowledge on the pudendal nerve (S2-S4).
Is this patient the the motor component - external urethral and anal spincters. Injury such as stretch during child birth, prolonged cycling, and horseback riding could cause this. Patients will present with decreased sensation in the perineum and genital area; can cause fecal and/or urinary incontinence.
It is also important to know that the pudendal nerve can be blocked with local anesthetic during childbirth using ischial spine as a landmark for injection.
(FA 2021, Pg. 675)
This question is testing your knowledge on cryptorchidism.
This condition results in descent failure of one or both testes; impaired spermatogenesis (since sperm develop best at temperatures < 37°C); can have normal testosterone levels (Leydig cells are mostly unaffected by temperature); associated with increased risk of germ cell tumors. Prematurity increases risk of cryptorchidism. Decreased inhibin B, increased FSH, increased LH; testosterone decreased in bilateral cryptorchidism, normal in unilateral. Most cases resolve spontaneously; otherwise, orchiopexy performed before 2 years of age.
This question is testing your knowledge on Candida albicans. When CD4+ is lower than 100/mm3 then the patient is at risk for a normal flora candida skin infection.
This question is testing your knowledge of being aware that when a patient is experiencing symptoms/pain that it may be due to a depression or a major depressive episode. This patient is experiencing symptoms but there is no apparent medical evidence for those symptoms.
This question is testing your knowledge on Lyme disease. The stem describes the patient as having a rash and flu-like illness 2 months ago, and now he is presenting with pain in multiple joints and fatigue. The stem is describing Stage 1 and 2 of Lyme disease.
Stage 1—early localized: erythema migrans (typical “bulls-eye” configuration B is pathognomonic but not always present), flu-like symptoms.
Stage 2—early disseminated: secondary lesions, carditis, AV block, facial nerve (Bell) palsy, migratory myalgias/transient arthritis.
There us also a Stage 3 which was not described in the stem:
Stage 3—late disseminated: encephalopathy, chronic arthritis, peripheral neuropathy.
Also, when it comes to treatment know that doxycycline is 1st line, and if you have a pregnant patient then you would prescribe amoxicillin or to patients who are under 8 years old. Additionally, IV ceftriaxone is required.
This question is testing your knowledge on the respiratory/conducting zone. The bronchioles are comprised of the (bronchioles, terminal bronchioles, and respiratory bronchioles) which all contain smooth muscle, the respiratory bronchioles have the most "sparse" amount of smooth muscle though. Together, these comprise the largest amount of smooth muscle in the respiratory tract and therefore would be most susceptible to flow limitation due to smooth muscle contraction during an asthma attack.
This question is testing your knowledge on tetracyclines. The patient in the stem is taking tetracyclines and had spent the day at the beach (a big no no) while on these meds. One adverse effect with tetracyclines is that they cause photosensitivity.
Make sure you know all of the adverse effects of tetracyclines and many of them have very bad outcomes.
This question is testing you knowledge on skeletal muscle adaptations (specifically atrophy). The patient is described to have cachexia and significant muscle wasting, these are manifestations of atrophy. Atrophy occurs via:
It is important to know the molecular mechanisms of atrophy above as these are what the test makers love to test your cellular and molecular knowledge on many concepts.
This question is testing your knowledge on Severe Combined Immunodeficiency (SCID). When considering a SCID diagnosis consider these aspects:
Defect:
Presentation:
Findings:
I believe this question is just testing your knowledge on type I pneumocytes and is you know that these are what comprise a majority of the alveolar surface area.
To be more specific, type I pneumocytes are of squamous cell origin and they cover 97% of alveolar surfaces. It makes sense that they would be made of thin "squamous" tissue as this is what makes them optimal for gas exchange.
This question is asking you about one very peculiar fact about Hepatitis E, and that is that is can cause fulminant hepatitis in expectant (pregnant) patients. This leads to a high mortality in pregnant patients.
Some other important things to know about Hepatitis E is that it is enteric and epidemic (e.g. in parts of Asia, Africa, Middle East), and that there is no carrier state.
This question is testing your knowledge on acute cystitis caused by Chlamydiae.
Chlamydial cell wall lacks classic peptidoglycan (due to reduced muramic acid), rendering β-lactam antibiotics ineffective.
Labs will demonstrate a (positive) leukocyte esterase. (positive) nitrites (indicates presence of Enterobacteriaceae). Sterile pyuria (pyuria with negative urine cultures) could suggest urethritis by Neisseria gonorrhoeae or Chlamydia trachomatis.