tri-CyCliC antidepressent - anti C holinergic, C ant stand up (a1 block), C ardiotoxic (prolong qt by messing w na channels)
Tricyclic and tetracyclic antidepressants, also called cyclic antidepressants. The peripheral anticholinergic complaints of dry mouth, constipation, ocular side effects and urinary hesitancy are described and specific clinical guidelines for their effective management are provided.
So, most common reason for noncompliance with cyclic antidepressant therapy is its anticholinergic effect.
https://www.ncbi.nlm.nih.gov/pubmed/3290996 https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20046983
Note: Please if im mistaken, or my approach is mistaken, correct me... Thank you
SSRI's make ya peepee not work, man no like when peepee not work. man stop taking SSRI. Point and Shoot: Erection= parasympathetic, so Ach is used for erections. Anticholingeric leads to lack of Ach which leads to no erection.
my best guess for why anti-cholinergic is worse than adrenergic or histaminic was just b/c they stick atropine with diphenoxylate to prevent abuse (tbh tho idk if this logic stands at all but eh)
Let's tackle down this question step-by-step: -C can be crossed-out (because TCA causes anti-M, not cholinomimetic side effects); -E can be crossed-out because TCA does not cause sympathomimetic ADR; -C can be crossed-out because anti-H effect is sedation (which is caused also by anticholinergic effect) + increased appetite/weight gain (which is something that, in my opinion, can still be under control by the pt-eg by correcting lifestyle); -the last 2 options are antiadrenergic and anticholinergic: both cause side effects that are difficult to keep under control; moreover, speaking in simple terms, anticholinergic cause a much higher number of ADR than antiadrenergic (alpha1 antagonism= ONLY orthostatic hypotension). Therefore, anticholinergic is the answer.
idk about yall but sketchy pharm: that table with the rabbit and stuff is HY. Pay attention to those
submitted by โseagull(1933)
Which of the following reasons is why this question is bull?
1) Using the word "cyclic" instead of tricyclic for clarity
2) Knowing all of epidemiology of all drugs
3) having to reason out that anticholinergic effects are probably the worst over alpha1 or H1 effects to no certainty.
4) The crippling depression of studying for days-to-weeks on end to probably do average on the test.