NBME 22 Decreased binding of RNA polymerase (NBME Answers)

Retired NBME 22 Answers

nbme22/Block 2/Question#35 (reveal difficulty score)
A 45-year-old man with Li-Fraumeni syndrome ...
Decreased binding of RNA polymerase 🔍 / 📺 / 🌳 / 📖
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+67 upvote downvote
submitted by ∗seagull(1933)

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Ddi oaenny eend ot drae htat salt esncetne ilke 50 tesim sceeuba teh otahur ssruefe ot ues erbtet gamarr.m uJst tgtsr.uraifn

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link981 uAorht oltaerna:i ath"W si ?agrmrma" +6

qfever dDi yenona eadr keil 50 ietsm dna ltils etg it ngwo?r L,L(O e)m +22

drbravojose ltyacAul eevrn anrdstuden wtha hte rauhto insagy ta any .imet LOL +3

alimd uhSc a syitth siu.neqot Do we lyrale vaeh hcsu ssietuqon on eth aerl ?eaxm nI ym noiinop tehy tjsu wroht jknu oneitqsu to tehso tsnamsesse +1

nootnootpenguinn hO my g-odonsse nakht yu!o I asw os adm ta rovehwe otrwe this ihtsyt !ntsiqeou Gto( it rogwn oll) +

xmen EYTH GEIV OTSMEIEM RIEWD OEUNTSISQ RUNDIG THE ELAR MXEA !N!A D! IST' XANPMEITEELR +

+12 upvote downvote
submitted by ∗hello(429)

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The aagrmmr fo teh autalc Q wsa cogifu.nsn

oT ekam rtbeet ,sseen ti udohsl yas "hWhci fo eth nlwilgfoo is teh mots kiylle lretus on the rinsatprtonci fo egsen atth itnhiib elcl idnvosii dan atth nanoict hte sscennuos useeqenec A.."T.AT

,oS het Q si gnakis oatbu eth 35pt nege dan lfiyscaelipc btaou het p5t3 eneg otrreomp eoignr.

oemtorPr siogner vhae a TAAT box o(ov,yulbis ingaenm hrci ni -AT asbe )arpsi. -AT baes iginarp ash 2 ydorengh nd,obs hicwh kmase ehtm ieares ot acleve t-&;-g lwolas orf DNA nnriatritcosp to ccuro orme liea.ys NAR loP osde anprntioisrtc fo NDA itno NA.R

eTh eirent sQmte- saltk oautb woh nLia-uemrFi si ued to a otmunita in p3t5 n,gee ldeaign ot a lack of turmo rpsuinoseps tvaiityc.

,oS fi eht reotporm engoir AATT bxo of the 3tp5 eegn is audttme, enth the 53tp egne liwl otn tge icrarebtdsn g;-&-t tish is wyh heter lwil eb seeaedcdr ARN olP igdinnb. ARN lPo wlli hvae a deuerdc itiabyl ot nbdi p5t3 -gt-&; essl tmrou erssruspo neeg pronctatriins ;-gt&- slse omutr epiosupss.rn

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jcmed atht udwol eb ovryel yeas fo meth htohgu eye orll +

whk123 eBts oen.ptianxla +

fhegedus dan udnlydes ntihvgeery amsek esnes D: khnTa oyu for a trega n!lexitopnaa ): +

+8 upvote downvote
submitted by ∗fenestrated(32)

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roF htsi noe I hknit athw oyu dah to wokn si taht ctoisrprnTnai D&Ng-A-NR;(A)t si poerrmedf yb RAN tlsempy.Ia eor was tno NDA raeesmpylo aeebucs ihts noe eslpeatirc DA-&tgAN;D-N()

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fenestrated eewebnt ieanredcs or rdasedece nnbgidi I dceipk edaedcrse useabce ti aws a tuiotanm whhic aedftfce het gynodrhe snobd iwhch si who censdoeltiu nidb ot ahce thero +1

makinallkindzofgainz isht si woh I ogt ti hrgit +

+4 upvote downvote
submitted by ∗yotsubato(1208)

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35p is uteadtm dna tcna nbdi het TAAT ob,x os ahtw hnepspa ot istprnacrinot of ihrbiyinto iopn?rtes

sI yaalscibl what sith utosnqie si intrgy ot .s..ak

So on ATTA xob orprmeot g;&t= scdaereeD bngidni of ANR osyeaprmle

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link981 uoY dsai ,it yhte era nigtr"y" to sk.a hlSudo ues beettr ga.rarmm +3

titanesxvi ihTs is no ifrst ad,i nad sysa ahtt hte rmotorpe roeign is rhewe mNAaselRrepyo dnbsi +1

nootnootpenguinn kuaanH OT-TAAN .ob..x nhakt oyu fro siht loann!ieaxpt +

+3 upvote downvote
submitted by ∗d_holles(218)

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Thsi is a oogd riuctpe of an entpexmire hsownig :tshi

en/terr1sgt2t2m6.st91/wua.r:ipae//lswiuhwc/1f0oc/

eonnegcO uemolv 2,6 gapes 2222912–1 ()2007

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+3 upvote downvote
submitted by dantescuttlefish(7)

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hyW si tihs nto cdnreiase dnbiign of NDA ers?pemaoly

isTh itmnuoat hlosdu saecu ulcalrle snoiidvi ie ADN piarlictnoe adn esacu drasnciee ginbdin to griino ceniitarlop squesecne ei TTAA by DNA eal.ryspmeo

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brise sI't gntliak aotbu utontmsia no the rsnatnciprtoi of eesgn atht iithnib hte llce .ondsiivi Alos ANR eopylsmaer dibsn to the optmeror r.oeing +

nwinkelmann o,lsA eht tenuosqi sfycaleiilcp oh(tghu ni a vyer rw,oyd otdnvoeclu ayw) edask twha hte fcetfe fo the tounmait no cinitnoprtrsa .saw NAD pol is tno used in isiap,norrtntc it si used in .celoiptrain ARN pol is udes in nstrotciarpin. In mrset fo nrcseedai ro ceeaedsrd b,ndnigi rgiinnga is paeotyvirloil/sp aderghc dan opelrin si rln,/epnoatunarol so rhete aer feerw nngoHidb- ,tesis dna uhst rdecaeesd bgnidin of the NAR .plo +1

medn00b ulodC tihs dnculveoto etonqsiu lsoa .hte..t. na.a..m... icsne eth eneg to kaem 3p5 si eedmss pu due ot eht enhgoyrd s,dobn NAR peamleysor illw tno eb leab to idbn to emka hte mNRA ... oS etreh lilw eb nccaer? esBucea 3P5 si a moutr s.os.r.ppesur mlmee kown ntahsk usyg +

+3 upvote downvote
submitted by ∗jessikasanz(9)

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tlo of dowr voimt to ask hwat" ndbis ot teh TTAA "box

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+0 upvote downvote
submitted by pipter(10)

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oDes nneyao ehva yna iscpfiec daie on eth isemcnamh of teh p35 imatunto netuqosi igdanregr eth ATAT xbo (the oen iwth teh ilgens oanmi aicd inrvscnooe nad teh rfftinede dohnreyg dnig)b?on

I ceohs het ceadeesdr gibndni of RNA semyearopl on eth ATTA ecusneqe of negse ttha ihitibn clel nivsidio dbsae sleloy no eht ctfa ttha 3p5 is a rtuom speusrsopr ak(a temudat s&;tlp5esg-3 oiitnbiihn fo eosutmni-tdgp;vii&lli .iosnidvs)i

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joha961 moFr a dnarom arepp I d,fonu Alrgaybu“ p’3s5 smot iamtrpnot untcifno is ot tca as a nspairtncriot tcfoar thta dyrelcti eatrgsuel appresh elvesar ueddrhn fo the el’cls RAN eoserlmyap II RNP(A IitncIdarr-s)be g.nese” So lyalmorn ti nsaciesre NAR lop ;nnigdib a umioattn would eacerdse t.i +1

estsosa eTh TAAT bxo si tpar of hte mortoepr goinre etis ewreh ARN esaropmley II dan roeht iiarcopntsntr fcorsta dbin ot A.DN A feectd wduol oeterehrf dacsreee dnibngi fo NAR mr.poayeles +7

mnemonia oslA yuo acn osaern it otu (I tgo shit gwonr becseau yuo veah to be aellyr )usmuilteco sncie ew know ttah lsso of 35p = canrc.e Cacren = ntwa orem ellc iidosvin = ndo’t twan oniytbrhii gene = sels spatrnitnrioc of sadi .eegn +1

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