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Retired NBME 22 Answers

nbme22/Block 2/Question#35 (reveal difficulty score)
A 45-year-old man with Li-Fraumeni syndrome ...
Decreased binding of RNA polymerase 🔍 / 📺 / 🌳 / 📖
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 +67  upvote downvote
submitted by ∗seagull(1933)
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iDd nynoea dnee ot read htat astl nesecten eikl 05 imste beaeusc eht auhtor sfresue to esu rteteb mmraa.gr Jsut .uftgrsatinr

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link981  urAtoh laoi:naert aW"ht si ag?"marmr +6
qfever  idD aynone ared lkei 50 semit nad tlsil get ti ?wrgno ,OLL( m)e +22
drbravojose  tyalAulc reevn duaetsndnr ahtw eht urhtao ynsgai ta ayn te.im LLO +3
alimd  Scuh a ithyst .intqeuos oD ew lrlyae avhe hcus qeotssinu on eth laer emxa? In my oioinpn ythe usjt trhow jkun ienquost ot oseth mssasenets +1
nootnootpenguinn  hO ym o-gdoessn hnakt o!uy I saw os dam at vreheow rotwe htis ihttys nq!toesui ot(G ti ronwg )lol +
xmen  ETHY GVIE ETSEMIMO WDERI USTOQEINS NGRUDI EHT RAEL AMXE !!NA !D 'TIS EMXEPIANTLER +



 +12  upvote downvote
submitted by ∗hello(429)
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ehT ragammr fo eth tulcaa Q was osicgnu.nf

oT maek bttree snes,e ti sdulho say hcWhi" fo het lfiolgwon si the otms ylikel sultre on het rtoisntparcin fo geesn thta niitihb elcl ividison adn thta toncina het oeusscnns eecueqsne TTA".A..

S,o eth Q si kgisna ouabt het 5tp3 geen adn cisplilyecaf bauto het 3tp5 egen rmoetpor giroen.

emPrtroo oesrngi ehav a ATAT oxb ,lsb(iooyvu gnneiam cirh in AT- aesb ia)rsp. AT- ebsa gnriiap ash 2 enodrhyg onbds, chihw sakem tehm erseia ot evclea g&-t;- slwoal for NDA ncsirtnipotra ot urocc orme ley.sia NAR Plo dose asnnitptrrioc of DNA iton AN.R

eTh rinete msQt-e ktasl tauob woh mLnieariu-F si due ot a imttoanu in t5p3 ne,ge aegnldi to a lakc fo tmrou esppinrosus iciaty.tv

So, fi eth ooptremr onrgie TTAA box of the 53pt egne is ,emudatt ehtn eth 35pt egen wlli not tge rcntsabedir -t-;&g htsi si ywh hreet lwli eb asedcered RNA oPl dnnigb.i ARN oPl will veha a ercdude iayibtl ot idnb 53pt ;g-t&- ssle muort usrrosesp egen anorinctirstp ;t&g-- sels rmtuo ness.iuporsp

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jcmed  atht doluw be lyorev eays fo meht htuhog eye llor +
whk123  estB pennio.axlat +
fhegedus  adn eldduyns rteeyhvgin mskea esens :D kaThn oyu orf a eagrt l!nenatxopai ): +



 +8  upvote downvote
submitted by ∗fenestrated(32)
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oFr itsh noe I nikth wtah ouy ahd ot nkow is ahtt stciiapTrnnro N-)A(gAND-R&;t is defmeprro yb ARN rye.posaIeltm aws ton DNA mlesorpyae saecebu stih one leeptiacrs ND(t&)g-AA;ND-

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fenestrated  etbewne eiradcnes ro drecdeaes nignibd I idkcep cserdadee ceubsea it saw a utoinatm hhcwi edtacffe eht yndehrog odsbn iwchh is how ieunedstcol bind to ahec ehtor +1
makinallkindzofgainz  ihts is who I got it irght +



 +4  upvote downvote
submitted by ∗yotsubato(1208)
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35p is euatdmt dan tanc dnib teh TTAA xob, so twha sephnap ot atrtniicprons of inohyribti iestr?opn

sI ailylcasb twha shti etoiunqs is tygirn to .s..ak

So on AATT bxo potoerrm tg&;= esDeaedrc bnnigid of RNA oapyserelm

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link981  Yuo sida it, yteh rea tyg"rni" to sa.k ldoSuh use trebte agrrmam. +3
titanesxvi  iThs si no isrft a,id dan sasy taht eht ortmpreo ngroie is weher oeNarmAseyRlp isdnb +1
nootnootpenguinn  aunHak NTOA-AT x.b.o. htnak oyu rof sthi i!etlnnoapxa +



 +3  upvote downvote
submitted by ∗d_holles(218)
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shiT si a odgo ucrietp of na epxmritene wnhiosg thsi:

hputrm/nc/s.erwst06/:/f91w1tatlu1osiairw/c.ege22/

cgOeneon mouvel 26, easpg 1122229–2 7020()

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 +3  upvote downvote
submitted by dantescuttlefish(7)
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hyW is ihst nto sradnciee gbnidin of DNA ?respayelom

hsTi iuatntom lohdsu suaec crllaelu sidiinvo ie DAN tclpioearin dan eacsu nrdcaisee nidnbig ot ngirio nicoelitapr unseceqse ei TTAA yb NAD eymoas.elrp

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brise  'sIt ntkgila outab tunstoima no eth irspotancirtn fo gnsee ahtt ihibitn hte llce .idinoisv lsAo ARN oeypalesmr bdnis ot het teorrpom onegri. +
nwinkelmann  s,Alo eth seiuqtno iaicflcslepy uhto(hg ni a ryev yd,rwo letnvdoouc w)ay asdek awth the ceetff fo the nutatmoi on tnotircspiran .saw DNA opl si tno sued ni iistcptrnrnao, it is edsu in rlacnetoiip. RAN olp si deus in roriaspct.nint nI sertm of srdeicnea ro eercdesda gnnbi,id ariiggnn si p/paoyrltovsieil dragceh nda lorinep is nparno,utenar/lol so ereth are eefwr oH-ngibdn sties, adn tuhs eeeddacsr ibdginn fo teh NAR l.po +1
medn00b  ulCdo tish udvnetoocl ousneitq laso .ae. ..hnt....am.t. ncies eht geen to mkae 3p5 is meessd up ued ot het ynghedor ,nbsod RAN laoypmsree lliw not be aleb to nbdi ot akme het mRNA ... oS teerh wlil be ?cnreac eaBecsu 53P is a rmout susos.pr..rpe emmel onwk nhktas ysgu +



 +3  upvote downvote
submitted by ∗jessikasanz(9)
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tlo of rowd tmovi to ask aht"w bnids ot eth TTAA xob"

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 +0  upvote downvote
submitted by pipter(10)
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seDo nyeaon hvea any scecfpii diea on het icehmasnm fo eth p35 inmoatut tsqeunoi ardgginer the AATT xob t(he oen with het lsnige naomi aicd nnrieocvso and hte itfeerfnd yhgrdeno n?giodb)n

I sheco eht ecdedsaer dnbingi fo NAR emplyaeors on eht ATAT seeenuqc of eseng htta tbiinhi llec iisvdino debsa lysloe on teh actf taht 53p si a trmuo urpespsosr aa(k uemadtt se&3s-tl;p5g hininibito fo ;eiomstgil&iputdvi-ln sii)nvo.dsi

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joha961  romF a naomrd rpaep I don,uf Aglrbay“u s53p’ stom npaimtrot cfnoitnu is ot cat as a rprtsnnitaoci oafcrt ahtt dlcyrite trlsaeuge spearhp ervasel uhrdend of the cel’sl NAR yrelsopame II N(PAR )ecatIbidrI-snr nse”.eg oS rnloymal it naesiescr RAN lop ngdib;ni a anmotiut owldu ecaereds it. +1
estsosa  eTh TAAT obx is aprt fo the oroemtpr einrog tise rhewe ANR yprsmoeale II nad hrtoe rintporsntiac rstaocf bdin ot A.DN A tcdeef dwoul trorheeef eaceerds inngdbi of NRA .emploersya +7
mnemonia  sAlo you cna enrsoa it tuo (I tgo tish gworn cusebea ouy veha to be eylalr lmoec)sutiu ensic we wkon hatt olss fo 3p5 = n.cacer aeCcrn = awtn eomr lcle oisindvi = otn’d anwt rinohitbyi ngee = sesl snraircnpotti fo asid eng.e +1



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