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Retired NBME 22 Answers

nbme22/Block 2/Question#35 (reveal difficulty score)
A 45-year-old man with Li-Fraumeni syndrome ...
Decreased binding of RNA polymerase 🔍 / 📺 / 🌳 / 📖
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 +67  upvote downvote
submitted by ∗seagull(1933)
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dDi nnyoae ndee to eard atht tsla cnesneet ekil 50 tsmei abeecsu teh rthoua fsreseu to use trtbee gr.rmmaa sutJ it.satnufrrg

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link981  truAoh ietalnoa:r "athW si "maarmg?r +6
qfever  Did nnoeya edar elki 05 tseim dna siltl teg it rgo?wn L,LO( em) +22
drbravojose  laylAtcu eervn drtandnseu wtha the rhtoau gaysni ta yan .eitm LOL +3
alimd  chuS a ihsytt tnies.uqo Do ew arlyel heav csuh netuqsois no teh rlea ?xema In ym niooipn hyte sutj tohrw jnuk eqntiosu ot oehts sssanmtsee +1
nootnootpenguinn  Oh my ogeso-dns haktn yuo! I saw os mda at hevwoer erowt shit ihstty eio!qsntu (otG it grown ll)o +
xmen  EYHT EIVG OMMTEESI IRDWE NEUTISOSQ IUGNDR HTE ELAR MEXA !!A N!D IS'T EXRENITLEMPA +



 +12  upvote downvote
submitted by ∗hello(429)
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hTe rmargam fo eth tuacla Q asw ocisgfn.nu

To aekm ertebt nsees, it ohdsul say "hihcW fo eth nligwlofo is teh mots kelyli tursel on het ciraoristptnn fo eengs htat inthbii lcle nviiodis dna atht iocntan hte seunscons eenucsqee "AAT.T..

o,S het Q is kasing tboua the 5pt3 egen dna llcsypacieif atubo eht 53tp egne topmoerr egionr.

mPoteror sorgine ahve a AATT oxb ul(obyo,vis niemnag crih ni T-A baes spr).ai A-T baes ngaipri ahs 2 dogynreh nsd,bo iwhhc ekasm mthe isaeer to alveec g;t-&- lwosla fro NAD antprnctoriis to crcuo eomr l.seyai ANR Pol osde ptirnitroancs of DAN oitn R.AN

Teh etnrei -setmQ lstka oabtu owh FeriiLumna- si eud to a tatumion ni 35pt eegn, laidgne ot a lcak fo tormu rseiospnsup tivycat.i

,So if eth oortpmer gieonr ATAT oxb fo teh 3tp5 geen is umttdea, ethn eth 53tp gnee lwli not egt dsbranicret ;--> this is hyw eetrh ilwl eb adseredce NAR Pol i.gnbndi RNA lPo iwll vaeh a eeurcdd ailitby to nibd t5p3 g--&t; sesl mortu susreopsr egne irncsttanrpoi -;t&g- essl otmru srenpsi.osup

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jcmed  htta ulwdo eb ylvore easy fo mhte utghoh eey lrlo +
whk123  esBt etaxn.lionap +
fhegedus  dan yeddsunl veyihertng seamk esnes D: hkanT uyo ofr a ategr epanox!antil :) +



 +8  upvote downvote
submitted by ∗fenestrated(32)
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roF itsh neo I kthin thaw yuo adh to kown si ttha oinriaspctTnr -gA-tNA&RDN(;) si erofmredp by RNA eepamotIlr.s y saw ton ADN yerpmsealo esubcae htsi noe rplceatsie gN&--)NDDAA;t(

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fenestrated  eentbew deniasrec or rseddeace gbinind I ikpdec derecades euesbac ti saw a iumtoant ichwh fdcafeet the orgeyhdn bosnd hhciw si who dnelueocsit dnib to ache etrho +1
makinallkindzofgainz  thsi is woh I got it rgtih +



 +4  upvote downvote
submitted by ∗yotsubato(1208)
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5p3 is admttue adn ncta ndib eth AATT xbo, so atwh spehanp to orpncrtasiint fo hribiynoti rion?spte

Is sclbalyai twah hist soqteniu is girnyt ot .ak..s

oS no ATTA obx opretmor g=;&t esceDarde nbginid of RAN omrpaslyee

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link981  ouY idas ,it hyte are "ny"tgri ot a.sk dlShuo use eebtrt aargm.rm +3
titanesxvi  sihT is no sfrit ida, and assy atth het ootrepmr nierog is rheew lereAyRmNaosp bnisd +1
nootnootpenguinn  kHuaan ATTANO- b...xo hnkta yuo for tihs x!aotipnlena +



 +3  upvote downvote
submitted by ∗d_holles(218)
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Tshi si a ogod eritupc of an neerempxti nwsihog si:ht

o/wa./ehts/ercist/r2f.autrmn90e21iwgpts:w6u/c1l/1

eenoOcgn oumelv 2,6 egpas 922212–21 002(7)

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 +3  upvote downvote
submitted by dantescuttlefish(7)
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hWy is tihs otn enrdciaes dibngin of AND ye?lrsapoem

iTsh omtutian olsdhu ucesa elllcaru ionisdiv ei DNA itcipanorle and acuse neaedrcsi gdnniib to igorni arnicietolp cesqnseeu ei AATT by ADN empsyelar.o

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brise  Ist' lntgkai aubto itnmtsuoa on het tiiosnprnrcat fo negse hatt inhtiib hte cell iso.diniv Aslo NRA mpeaylreos inbsd ot het rmoeprto rnoie.g +
nwinkelmann  ,solA eht nqsoiuet yaflcilisecp tg(ohhu in a ervy do,ryw vnolcteoud awy) daesk twah het efecft of eth toaitmnu no tnrtrsinaiopc .was ADN lpo is not euds in rcnot,sitranip it is sude ni eilrntoaic.p NRA olp si ueds in ratsncnpiort.i nI mestr fo ecrnaisde or dreaesdce d,gininb gingianr si lrpsoptlyiv/eioa dahgrec nad rpoinel si rr/antlaonpe,lonu so eerht era eferw bH-indong isse,t nda tush eerseadcd nibdgin of teh RAN plo. +1
medn00b  uolCd siht ovedntclou oqtsniue olas hme...na....a..t.t icnse the nege ot aekm 3p5 is essedm pu deu to teh doegrnhy dbso,n ARN psloymeare lilw not eb bela to dbin to make the mRAN ... oS eterh iwll eb c?anrec aeBseuc 5P3 is a tmoru pp.e.r.srossu elmme wkno hntsak sguy +



 +3  upvote downvote
submitted by ∗jessikasanz(9)
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lot fo odrw viomt to kas "hwta nibds ot hte TTAA bxo"

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 +0  upvote downvote
submitted by pipter(10)
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eDos oenyna vhae nya ipiefscc eadi on teh iancmsmeh fo hte p35 onitatmu nquostie adgnrigre eth ATTA box (eth eon iwht eth lisgne noiam daic encoisnorv nad het neefirfdt ydrnhoge n?iodbgn)

I hecso hte eescreadd dbiignn of RAN rlyomsaeep no eth ATAT esnequec fo esgne tath bnitihi clle iiidonsv bseda olelsy on het tcaf ahtt 53p si a romtu usespsorpr aak( tueatmd -s;3g&pst5le ininibitho fo gipuitnllioi&;t-vsedm ivs.i)dions

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joha961  rmoF a rodman parpe I ,ndouf gr“Aaylbu s’p53 msot rptniatmo ntoiuncf si ot act as a ptironcntaisr ofrcta ttha citredly atgrseeul rhpeasp esvaerl dhrendu fo the lcle’s RAN reomsapeyl II NA(PR bIiascr-)dInter eneg.s” So nolaymlr it acnrssiee NAR plo d;nbngii a aiutmtno wulod edsreeca .ti +1
estsosa  Teh TTAA box si rapt of the reoopmtr ogreni siet reewh RAN yroesmlepa II adn throe iirtncnstorap trofasc dnbi ot .ADN A edftec lwuod eherfrteo cdeeeras ingdnib fo RNA oryme.slepa +7
mnemonia  loAs uyo acn rnesao ti out (I got thsi worgn ecabeus oyu vaeh ot be aylrle eiu)lsmucto niecs ew onkw that olss fo 35p = caecr.n renCca = wnat rmoe cell isionvdi = t’ond atwn tyhibrnioi eeng = less pnatconirirst fo dsia ege.n +1



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