NBME 22 Decreased binding of RNA polymerase (NBME Answers)

NBME 22 Answers

nbme22/Block 2/Question#35 (reveal difficulty score)
A 45-year-old man with Li-Fraumeni syndrome ...
Decreased binding of RNA polymerase 🔍 / 📺 / 🌳
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+76
submitted by ∗bubbles(79),

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stuJ sa oiar,tafiiclcn ycprlalia roicystthad purresse loudw cderasee aseecub fo cssytmie coiiotctnvroassn ni enosrpse ot criaot /ecumsptytisurre eypnsono?thi

+67
submitted by ∗seagull(1923),

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Ddi eoynna eend ot erad thta alst etnsceen lkei 05 esitm ceaeubs eht truoah esufser ot seu reebtt rmma.gar utsJ fiu.snatrgrt

link981 truoAh a:altneori W"hta is ?g"raammr +6

qfever dDi aneoyn adre ekil 50 isetm nad tslli teg it n?rowg L,OL( )em +22

drbravojose caAullty vrene eanrtdsdnu hwat teh rouath gsnayi ta yna emi.t LLO +3

alimd cuSh a thtsiy n.ieqsuot oD we lylaer haev shcu siustqnoe on eht lrae ea?mx nI ym oioipnn thye usjt hwtor njuk uteqnois ot ehtos eesanstssm +1

nootnootpenguinn Oh ym osgno-des anhkt uyo! I wsa os amd ta heoevwr oetwr thsi tyhsit o!isnqeut Got( it grnow llo) +

xmen HETY GIVE SOEMMTEI RWEDI SENUQTSOI GIRNDU ETH ARLE AXME D! !N!A STI' ETMXALNPEIRE +

+12
submitted by ∗hello(428),

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ehT rgarmma fo hte acatul Q swa n.cisuofgn

oT akem tebtre sn,ese it losduh ysa i"chhW fo the giowlonfl is hte msto ekllyi erstlu on eth trsptanrioicn fo egnse atht tiihbin lecl ivisodin dna htat tnaicon the suscesnno nsueqceee T.TAA.."

o,S the Q si ginska btoau hte p5t3 egen dan ilpacfesliyc obuta hte 35tp neeg romroept eorgin.

orrPomet nsriego haev a AATT obx is(uvloo,yb ennaimg cirh ni T-A esba .iap)rs T-A ebas npriagi sha 2 hdenyrog bsdon, hwhci aeksm htem eaeris ot elecva t-&-g; alwlso rof DNA aptroitsncirn ot crcou mreo .yseali NRA Plo soed cnotsrrtpaiin fo ADN onit N.RA

hTe enteri stemQ- altsk buota who ranuiiFm-eL si deu to a toaunimt in pt35 e,eng daegnil to a ackl fo urotm eipsrospsun ctviit.ay

,oS if hte meotrorp irogen ATAT xob fo eht 35tp eegn is temu,atd tenh hte 35pt gene iwll otn egt rdtirsnecba -g;-t& hsti is hyw ethre lwli be saeerddec ARN Pol ninb.dig ARN olP lilw heva a eerdcud ialbiyt ot dnib 3p5t -g;-&t lses rmout sepruorss eeng tniaicntpsrro g;-&t- slse trmou sss.rpniuope

jcmed taht duwol eb lyrevo ysae of ehtm huhtog eey llro +

whk123 Bset pa.naoixtenl +

fhegedus nad nddlusye irvgeneyht kemsa sesne :D hkanT yuo rfo a agetr tlepoin!axan ): +

+8
submitted by ∗fenestrated(32),

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orF shit oen I nhitk wath oyu had ot onkw si hatt orTracniispnt g&NDt)(ARN--A; si rrmfeoedp yb ARN yp.eaI stlroem saw ton NDA aoplsyeemr asbceue htis eon tesliecapr -NN&t-AD;(A)gD

fenestrated nbwetee iseendarc or dsdaeerce nnigdbi I ckepid ceedsdrae aseubce ti wsa a ttaiuonm cwhhi aftefced eht ohndgyer ondsb ihchw is owh dtenisclueo ndbi ot hcae ehrot +1

makinallkindzofgainz hits is who I got it rhtig +

+4
submitted by ∗yotsubato(1204),

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53p si tmutaed nad tcan bidn het TATA oxb, os thwa spnheap to crnprnsotiati of itoyhriibn erptn?osi

sI cbsilyaal twha hsti uetnqiso si gynrti to k.sa..

oS on TATA box etrmpoor ;>= seadDecer gidbnni of NAR empeolyrsa

link981 ouY isda ,it yhet ear yngr"t"i to ak.s uldSho use tetber mrara.mg +3

titanesxvi Thsi si on tisfr ,aid and syas atht teh otropemr ingoer si rwhee leymRsroeApNa dbsni +1

nootnootpenguinn Hnuaka ON-TAAT bo...x nhtak ouy for sith anpinxletoa! +

+3
submitted by ∗d_holles(219),

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This si a odog crepitu of an exmnrietep hsowing si:th

uew22swmtcu.r/9esr6/w/1tolt./gs1a/nirptei0cf:1/ha

Oennocge ouemlv 6,2 pegas 121–92222 )070(2

+3
submitted by dantescuttlefish(7),

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Wyh si ihts ton cdaeierns nngiibd fo DNA eprao?slmey

hsTi intamotu dolshu cuase lralcule niiiovds ie DAN lciineotrpa dna eucsa iedesrcan nngidbi to riiogn clotienpira unesecqse ie TAAT yb AND myrpaoel.se

brise 'tIs nailgkt otuba unmasttoi no the ipcirtasonrnt fo nseeg htat biinhti eth ecll oidnvsii. lsoA ANR ealyesoprm sbdin to eht roetopmr eo.irng +

nwinkelmann Ao,ls eth itsonequ liyclsaecfpi (ohhutg in a yrve rywdo, neovtodluc a)yw asekd awth eht etffce of teh titunoma on tiirnorcanpts a.ws NAD lpo si nto dsue in tsniotic,aprnr it is edus in ilatc.erpnio ARN olp is sude in tcr.aopninrsit nI rtsem fo cnreeiasd ro eedesdacr ,nbinidg ignirgna si lielop/vaispotyr caedghr adn nepolir is opnl,/nltnoaurrea so ereht era ferwe iHb-dnnog t,isse nad hsut edeesadrc dgnniib fo hte RAN lop. +1

medn00b uolCd ihts lecnoduotv sinoteuq also ha..e....t.mn ..a.t icsne eth ngee to emak 35p is emsesd up edu ot het nerodygh sdonb, RNA epoeysarlm will tno eb bela to dbin to meka the NRAm ... So erteh wlil eb accr?en esacuBe P53 is a omutr sesop.u..prsr lemme nowk nsakht gysu +

+3
submitted by ∗jessikasanz(9),

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lto of rwod vomit to sak athw" sinbd ot eth AATT o"bx

+0
submitted by pipter(10),

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soDe anonye aveh nay icfipsec eadi no het saenihcmm fo hte 5p3 tiotamun isunetqo grgdierna eht TAAT xob hte( noe hiwt het iesgnl imona adic nvecisoorn adn eth eeitffrdn dghrnoey gbd)oi?nn

I eohcs eht cdedeersa dibginn of RAN asleypemro on teh ATTA uqnceese of eseng that itniihb llce diiisovn dbsea elylos no hte ctfa htat p53 is a ormtu pesosrrups aa(k atduemt t;l&sgp3e5s- inoitihbin of ;ivipimittldgoe-nslu& osisid).nvi

joha961 oFrm a ndoarm apper I d,nfou lbyr“Auag ’35sp osmt raotmtnip coniftnu si to act as a cannpitsortir rtcfoa ttha tdirycle tsueagrel apepshr ravlese rdhunde fo het cle’sl RAN esyleoamrp II ANRP( crr-bseIIi)ndta e.sg”ne oS mnlyoral it sscrienea ARN lop ndg;nbii a unomitat wdoul deeascre .it +1

estsosa ehT TATA xob is tapr fo eht mertpoor rngoie teis rweeh NRA rlmapsyeeo II adn rothe srtrpnanociti stfacro indb to D.NA A tdeecf owlud eterhefor rdaesece nniidbg fo NAR so.lraeempy +7

mnemonia sloA uoy anc sneaor ti uot I( gto hits orgnw uceeabs yuo ahev to eb layrel tlscuomui)e icsen ew ownk hatt ossl fo 53p = c.eranc rceCna = atwn rome lecl vnosdiii = on’dt tanw ybnrhtiioi egen = sles nasoinirtptcr fo siad gen.e +1