eTh cpnotec si a eovoctndul way of ksanig if uoy wken owh JDV nmrtbicnaoieo kowr,s whcih si atth it si lltyacau an epaxmel fo lgneiatr eth NDA fo teh BT/ opeythclmy.

untSroeh lotb iqhet:ceun oS ehwn yteh use a beopr snagita osme rneig,o dan tuittnupgo a zies of 1.5 bk ro 6 b,k sith si illnteg yuo teh zise fo het AND gmtreanf ni each llec nst(de’o ermtat if hyet ysa J prebo or stnnacot ngorie roe,pb ’eryeht tusj yasign rhytee’ atengtirg oesm dtoeluicne neeeucsq oundf in eht Ig uCTsocl/R etab nhcia lousc clvitryseepe fro TB/ ecl)s.l

I hnitk the ofgucnins arpt cdulo be ngidenrow owh yuo wokn erhehtw ueyor’ lprtay rhhguot naemtrarnrege aesw(nr coeshic B rhut )D ro fi it snat’h rdueorcc ta lla yet (ecrtroc e)s.nrwa eH,re het otnpcec is htat B slcle oergnud )JVD( rmteaeeargnnr in eht bneo rmraow, ilhew T llsec do it ni hte uhym,ts adn it lal ahpnpse ta .noce oS a mpasla elcl in het blood eikl ni tlleuMip Mmaeoly udolw have ulfly dneonruge itenmobnicroa, iwleh a T lcel ni het bodol uocld reteih be llyfu uadtdeec n(ad eahv fsnidieh VDJ oibrcn)niaomte ro meamirut (stn’ah tdstaer VD.J)

ieScn teh T lelc ngee wsa 6 bk dan fiyetinedl bgreig hant the 15. bk e,gne the T lcle nt’ahs edoeugnrn coanribeoinmt tye.

othSr aewrn:s All gsnee rae eetsnpr ni obht B dna T lelcs, but eyth rrngraaee nda pexsres tprsoceer taht ear iescifcp ot teihr ai.nleeg hTrei aer ennntddiepe VJD egsirno rfo B lcel teorcper tnaeginoer dna T lcel reetcpro gor!ieteann Tsih kiiw rticeal hdses tligh no sht:i

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I oto rtyagalilc ssiedm .ihst. ubt it is uaylaltc os imeslp tath we rae smnigsi hte toerfs thuhrog eht tseer Wle-i -h tobh B nda T clsel gdneruo VJD mtaenanee,rrrg het V, ,D and J esneg are NFEFEITRD GESNE etpdeis gnibe iorendgza dna efrhrteoe ssaidlcfie ni a irlimsa oihasnf ude ot hrite saerdh dnee ot ereagnte redvsei rsuctert.us To kame rtsetam rmoe sgifu,cnon tobh stse of JVD gsnee rae on msomoeocrh .14

Tihs si hyw hte NBEM esifcpide htat eyth aer ggtiang THE EASM J NGERIO wcihh si htat fo hte B ecll eprector egne J gonir,e nto eht T lelc cetrproe neeg taJbe- rngoei ee(s kwii tcl.eira) The B clel erceotpr egen is otn gaeraerdnr in a T ,elcl if ti aws, T leslc uldwo eavh boen!idtisa

hTe ywa I thouthg baout shit ntiseqou saw ttah in MM heert is a NTO fo dntasibeio nebig a,mde os the DVJ netgmes si bieng onrbke es/ednpatergucreea/drl anmy itesm nda hsa neeb snhrteedo to k..b15 sA rof hte T ,leCsl atht inrgeo nit’s ibgen usde c(isen tereh si no loclan einoanpsx ro e)scoeiltn so ti’s slilt otg the lful k6b gnlteh e.chnuoutd

Wilhe T celsl od sue eht DJV emontia,inocrb teh T lcle eteprorc nihcsa era derfntfie ensge omrf eth B celsl' yehva and glith nishac. ienSc tehy dsue a B clle geinrJo- ,rpoeb hte T 'sclle dnab illw eb much arregl as isht arae fo tis ADN (teh B lcle vhaye or htgil hican enegs) heav nto eebn areardrneg -- diaetns sit T clle ereocrtp neseg heav bnee de.eagnrrar

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