The tcencop is a ctdneuloov yaw of sankig if ouy nekw woh JVD orcinmaotiebn rkw,so hcihw si ttah it si aallucyt an mlpeaex of arnitelg teh NDA of het /TB et.oypylhcm

rthouSen tlob euhectni:q oS nhwe yteh esu a erobp asantig mseo in,roeg nda ignputoutt a eszi of 51. bk ro 6 bk, hist si lilngte you eth isze fo hte DNA amftnrge ni ahec lelc ’dseno(t atemrt fi yeht asy J eobpr ro tcotnsan nrgeoi poerb, erhe’yt sutj nsgyia yte’hre gagtnrtei meso lnuietcode esuecneq dounf in eht Ig ClTosu/Rc eatb ianhc lcous leteecirpyvs ofr T/B sl.)lec

I htikn hte usfocngni rpat cdolu be gowdneirn who uoy owkn hertehw oy’rue aptryl gothrhu ramtreeangnre srwe(na seicohc B turh )D ro fi ti ts’ahn dcreuocr ta lla tye trceoc(r ).ranews e,reH the cenotpc si ttha B slelc godrnue VJD() grretrnanaeem in eht eonb wmo,rar leiwh T lscel od ti ni the sty,muh nda it lla psaenph ta e.ocn So a maspal cell ni het obdol iekl in puleiMlt Mmoeyal dlwuo avhe ullyf unegoednr eic,omnnribota iwelh a T llec in teh lbdoo odlcu ieerht be llfyu tuceeadd (dan vhae sifhenid VJD oitabeo)icrnnm ro umteirma hsa’(tn ttresda )V.DJ

Seicn teh T lecl geen saw 6 kb dna fiyeneidtl rgibeg anht het 5.1 bk neeg, the T lcle n’hast nenodegur bearinocotmni ey.t

othrS aswern: llA gesen era eetrnps ni tbho B and T sellc, utb tyeh gerranrae nda ersesxp rcpoteres htat aer cfsiicpe to etrih a.eenilg rThie rea pedntinnede DVJ engsior rfo B lecl ceoetprr ritgnnoeea dan T clel teorrcep no!iegarnet hTsi kiiw aictler sdesh tihgl on hi:st

lt/i.tnci_iti.ieebelope_wopgmDonsertciwokJVrkn/r_cid(r)#aep:a//hsT

I oot tcylraglai ssemdi ..hsit tbu ti is yuctalla os smeipl tath ew rae nmgiiss eth etrfso hotuhgr het erste ieW hl-- tbho B nad T lecls udoreng DJV tremr,ragnnaee het ,V D, dan J eegns are DFEIRFETN EEGSN epetisd gnbie eiagodzrn nda efheroret alciidfess in a rmsilai osnfhia edu to eihtr ersdah ndee ot enratgee disvere .custrstuer To aemk rttaems orme onfu,igsnc btoh stes fo JVD sgene era on heomocmors 41.

siTh is ywh hte BMNE pefceisid ttah tehy are itgngag EHT SAEM J RNGEIO chhwi si atht fo het B cell ptocerer eeng J neroi,g tno teh T clle rctrepoe gnee baJ-et inergo ee(s ikwi cr).iaetl Teh B ecll tepecorr gnee is not gnreeradar ni a T le,lc if ti s,wa T lelcs dulow evha d!aenisoibt

The ywa I tthough utboa ihst iunosetq was ttha in MM eehtr si a TON of bioteaisnd ebgin ,dmea so the VJD smetneg si egnib krnobe pedeet//lenerrrsadcuag naym smite and has eneb ehtrneods ot 15.k.b sA fro eht T C,esll tath rinoge s’tni igben udes nis(ce terhe si no olacln oapnixnes or oil)tcsene os ’its stlli tgo teh lful k6b lhtneg uotneh.ucd

ehiWl T cllse do sue eht JDV mcanieirn,otob eth T cell copterre saihnc rea ideffnetr nesge rfom eth B l'cesl hevya dan htlig sh.nica Seinc yhet euds a B llce nigroJe- perob, het T lsc'le band lliw be much lerarg sa shit area fo ist DNA eth( B llce avehy or hgitl canhi eseg)n hvae nto nebe rderenraag -- iedtsna sit T lcle perocter enseg vhae enbe a.dreenrrag

n/tro_bs2bqtpo.1pq4rbmen7wos2/ea//eler/iwn/um_xs:csolnh_isestirm_apzldtc_pen/tetw_nietou.et/medhp