Sroth wans:re llA gnsee ear penrste in thbo B nad T ,ellsc tub tyeh egeranrar nda srxeeps sperocret ahtt rae iiecfcps ot irhte l.aeigen Tehir era ennteiepndd DJV segniro ofr B lcle rperteco oiangnteer dan T ellc rcpetreo r!eeitnaong ihsT wiki reitcal sdehs ilthg on s:thi
rtee/_.crbweociegr/_rc/tko/nDpdo#kliwipehTVtnisaisini(J_t)o:aplme.
I oto tygairclla misdes .t.hsi btu ti si yaltacul os epsmil thta we ear iginssm eth ftores tgrhhou eth erste W-h-il e boht B and T scell udgnero DVJ rgnaremnrteea, eht ,V ,D nda J egsne are DRFTINEEF GENSE stpiede iebgn idgoarezn dan orreeehtf cadiisself ni a isiralm hfoansi eud to rthie hdesra need to geeertan sievrde us.srcettur oT eamk atsrtme orem nfgcosn,iu boht tsse of VDJ egsen ear on hrcmosmoeo 41.
hTsi si wyh teh MNEB seidepfci thta they rea ggaingt EHT SMEA J NEROGI hhciw si htat of hte B llec coperetr gene J ro,neig otn het T cell rtoecrpe gene -tJeab ioreng ees( kwii tclaie.)r Teh B lcel eetrpcro nege si otn rrgneerdaa in a T el,lc if it w,as T cesll lduow eavh todiibsne!a
Teh way I ghhttuo obtau shit tuqiones asw ttah in MM three is a NOT fo beintisaod gnbie ,eadm so teh DJV enemgts si bgien rnobek pet/ed/gaesurarcelnrde naym timse nad ahs nebe edthreons to 1.5k.b As rfo hte T ellsC, htta noegri s’nit eingb udes c(snie erhet is no clloan pieoxsnna or leinco)tse os ti’s tilsl ogt eth full 6bk hnlegt huot.cunde
While T slcel od esu eth VJD cobitanmeio,rn eth T ecll tecerrpo hcsnia aer tnefeifdr genes mrfo eht B csel'l vahey nda tlhgi is.canh eciSn yhet udes a B lecl Jreo-ign pobr,e the T s'ecll adbn illw be cmhu argrel sa tshi aera fo ist DAN eth( B clle vehay or iglht hanic e)gnse hvae nto bene redagnrare -- dseatin its T lcle rtopreec nsgee eavh eben .ngrrdaeear
eesescmon.r://en1/lt_/hmtloelpq/hbmr_uq7oxsnoe.aibirebn__suiwn2/_2ttee/cap4drneswoiw/tmstdpt_pptz
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$279$49ehT pocnect is a ocldutvone ywa fo gnaski fi you wkne owh DJV itniorambecno sk,wro cwihh si that ti si yctalaul na elpmxae of itlnreag the DAN of eth T/B eylhmpcyt.o
uoSrnteh olbt cueniqthe: oS newh ehty eus a ebrop sangtai eoms egior,n dna gtiuonpttu a ezis fo .15 bk or 6 bk, htsi si eltlign yuo hte seiz fo teh NAD emafgrnt in ache lecl d(’eonst ermtat fi yeht sya J ropeb or ttnaonsc iegorn boer,p ’treyeh stju ngyasi yet’rhe itgerntag esom etonicledu uqnescee unofd ni hte gI lcuRosTC/ tbea achni csolu etlpirsyvece for TB/ .)clles
I tnkhi eht sugconifn part oucld eb ownrdgeni ohw uyo nwko thwheer eoury’ laytrp gourthh ntreeargaemrn (ewsarn oiecchs B thur D) ro if ti ’snaht rccreduo at all yte t(reocrc .rns)wae ,Heer het peocnct is ahtt B elcls rugdone DJV)( mrngtaearneer ni teh nboe ,romwra lwieh T llecs do ti ni hte m,ystuh nda ti all pehpans at o.cne So a almasp lcel in eth lobod klei in ilMetupl olyMmea uldwo ehva ullyf nneudgoer mtoaicno,enbir hweli a T lelc ni hte olodb cdoul eeirth be flyul duteaedc (and vaeh dishnief DVJ tiiononercba)m or muritmae (ansh’t aresdtt DJV.)
cienS hte T elcl geen aws 6 bk nad fleyieintd igegbr anht teh 1.5 bk ne,ge eth T cell t’nash onreneugd mtoocbaeininr t.ey
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