poeh stih mgaie hple ot atsrdndune i,t the ppmsu 'ondt orwk eascbue alkc of TAP

In ralulcel isciem,ah eth +Ka/N+ aPTeAs upmp ostps gwnkoir due to ereedcads TPA lvels.e uneClosey,ntq sdmiuo si tno duppme uot dan mtsopaius is ont updmpe iotn hte llec, liadegn to an ccuuialmotna fo oidsum ni eth lcle dna siaptoums oiteuds the el.cl hormtue,rFre het parlicsosacm trclumuei aAPCaTse- pump ia,lfs chhiw dlsea to na rnaeiesc ni ilccuam in hte clel.

otBomt el,in ccsiehim stsuei: eerht si a luipubd of udsomi dna aucmlci ni the clel.

I egt atth teh rweans is trrocec orf a eilebversr rnuiyj ewher rehte is lelc swlilgen escbuea fo hte eiransecd eatcurnlarlli aN+ dna Ca2+ edu to ierimpda K/aN dan pamrscacisol muuceritl vyititac ...

uBt if etehr era inceesdra racdcia sneyzme in het obldo giidnancit cell aedth nad abmenrem e,daagm w’tudnol eht rlrlcntlaeaiu etocsrtllyee eb owl cnesi yeth ear laeersde oint eht bd?olo

I hgoutth siht swa a terypt dogo mrsuamy rfmo kpiidaeiw.

etpSs -41 inplaex eht :suitnoqe

1. kcaL of nxgoey sausce het [scricaomod'teyy] ranlom cesospr orf niamkg PAT orf egenyr to li.af
2. eTh lcel tshicwse to beoicraan omslmta,eib gpncodiru cltaic ca.id
3. -lneAraPTti noi ptaorsrnt upmps a,lfi iucansg teh llec to ecebmo zdroa,eieldp lngwalio isn,o nugdnilic iacumlc C2+,a() to lwof nito eth c.lle
4. ehT oin uppsm anc on ngorel rtnrsotpa ciluamc uto of eht lcl,e nda raecillluartn cumlica slelev get oto hh.gi

rnoAteh yaw to ntkhi utaob hist si sutj atht seredacde O2 alesd to sucydofntin fo teh Ka++/N eAaPTs sa tohres vhae o.deeintnm

ihsT is prteyt mhcu dincleiat to eht mchmiesna of i,dgioxn chihw locbsk the KNa/ eTaAsP dan amlcciu tacuumeacls ni eht ellc cebsaeu it antc eb hdecengax rof erutlcllraaxe +aN hchiw( is ton nilrurcalltea deu to cfeevtide Na/K ePTAs)a

If yuo wkno teh OMA fo nxigido uoy ludosh be lbae ot teg this ituoesnq r.hitg