eohp tsih meiga hlpe to sddeaurnnt t,i het pspmu tdon' rkwo aceuseb alck of TPA
In cellular ischemia, the Na+/K+ ATPase pump stops working due to decreased ATP levels. Consequently, sodium is not pumped out and potassium is not pumped into the cell, leading to an accumulation of sodium in the cell and potassium outside the cell. Furthermore, the sarcoplasmic reticulum Ca-ATPase pump fails, which leads to an increase in calcium in the cell.
Bottom line, ischemic tissue: there is a buildup of sodium and calcium in the cell.
I etg atht het raenws si rrcotec ofr a erivbleres irnyju wheer hrete is ellc nwlilges uceasbe fo the cadineser atirlearlucln N+a and a+2C ued ot rpediima a/NK adn ccsaiaomrlsp trimcuuel ictitavy ...
tBu fi ehret rae dacienrse acacdir ezymnes ni eht oolbd dtgininiac llec tahde nda brmmneae maad,ge tdlwn’uo eht nrulrlatlaiec retetllcoesy be wol iscen yeht are eesalder oint hte l?obdo
I thought this was a pretty good summary from wikipedia.
Steps 1-4 explain the question:
Another way to think about this is just that decreased O2 leads to dysfunction of the Na+/K+ ATPase as others have mentioned.
This is pretty much identical to the mechanism of digoxin, which blocks the Na/K ATPase and calcium accumulates in the cell because it cant be exchanged for extracellular Na+ (which is not intracellular due to defective Na/K ATPase)