aMnidlane Gs:eicnet
nMa ahs 3/2 cnchea of nigbe a er.iarcr (He dose tno ahve the esia.e)ds aW mno cerarri rsik mtus be ucalletdac htiw 2p^ + q2p + 2.^q 2q^ = 400/01,0 q = 00,1/2 p is guhrlyo = q 1p2 = 010/1 = eairrrC urqfnecye .
sRik fo ivghna a ihldc thus asuelq /23 x 100/1 x 4/1 = 0160/s a3e e2uc/B: = aMn erriraC rksi 0101/ = eFamle arreiCr R/ i1k4s = heCacn ehty ahec spsa no the csieesvre enge to tehir offipg.nrs
sThi eht sema as cnoaym'yskp@e teonialxpan thiw ermo pnaiaxloten shteo hatt need ..t.i
Teh paetnit si nfecutfdea by teh atucparlir tmaalouso sreivecse sseedai dna sih heotbrr sha hte utmooslaa eeeiscvsr aesdsie -g&-t; hist nsaem ceah of itehr tasrpen raiercs teh RA .lleael o,wN orf the tiaepnt ot be ntfecfeadu gievn atht btoh sih esatnpr avhe het AR lleeal, ti nsame hatt het eptiant has a 23/ hceanc ahtt he is snmtlayseouuli ducfaentef nad a e.criarr
heT tse'iatpn rteaprn is eufatedfcn adn malron -WgaybrdHenrei itsencge (sa seattd ni hte ..erwbn)mhpleo hsti is fplclcsaeiiy mden,otnei yuo are to ssamue atth teh eaprrtn ash a arrcrie ncquefyer rfo eht RA ,llelea whcih alueq ot 2.qp
ehT dsesiae ahs a eerqyfunc ni teh nuoipaoltp fo 00/410.0 Tihs is ^q2 tg;--& ^q2 = 0.04/010 ovlniSg rof ,q uyo etg q = 20/1.0
rCriera feuyqnerc si 2q.p Hervwoe, for a raer iesds,ea qp2 ≈ 2.q S,o het rceairr efeyunrqc for hte rrpetna = q2 = 2 * 2/100 = 1/10.0
o,wN the Q assk uatob na infgpsorf of eht pinatte nda ihs tpearnr ibnge ffdeteac, os ot hvae an ecaftfed ,dhlic htere is a 41/ nacehc of navhig an teafedcf lidhc bcesas(ue teh taipent dan het aenrtpr hbto heva a 21/ cneach fo anpgssi eht eelall -g;&t- uoy ulleitpm hstee etrhgoet 1/2 * /)12.
S,o tmlilupy 3/2 * 01/01 * 41/ = 6/.010 shiT si ian(tePpt ibegn a criaer)r * e(tarrpPn gebni a rce)rrai * hiPnagv( an effedact nfpgfiors h)etter.og
hTe liptirbbaoy of hte rfhtea nibge a rricare is 23/ isenc ti is oknnw htta he ’nsedot eahv the dse.easi hneT het bliypitraob fo ihm nspgais ti no to hsi kdi is:
/21 * 23/ = 13/
hiWt teh eWHaredgriybn- rpilenPc,i yuo can rugief uto the tpaibobriyl of eth htmreo egibn a ercai:rr
q = (40rt0,10/0s)q = 201/0
So, 2qp = 2 * /0201 * 92190/0, whcih paporx is 11,/00 adn het bioilrybtpa fo teh hilcd itggtne this lleeal is 100/1 * 12/ = 2/100
u:Ths
/0012 * 13/ = 16/00
hyw rheet is ryliabtbopi of ehftar egnib a rrciera si 23/
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49aaCltlusoicn fro dda. ehT rpbbioitlya fo eht tfehra binge a rcerira is 32/ iscen it si wnnok atht eh eto’snd veha the .sdeseai ehTn eht aoliibpybrt fo hmi isasgnp ti no ot hsi dik is 2,1/ u:tsh
sicaolantCul ofr omm. itWh het enWHriydeba-gr rnelcipPi, uyo can uigref out eth iaroypiltbb fo teh teomhr gebin a er:rriac
q = t/qr410,0)s(00 = 120/0So,
p2q = 2 * /2010 * /109902, hchwi si pprxoa 0101/.oFr eht dhcli to teg eht laelel mrof omm, two gstinh ende to hppea:n (1) mmo usmt be a rerraci h]y“[ee”zteogort adn 2)( omm mtsu apss eht lelael to cl:hdi
gitnPu ti lal eretthgo. wN,o coibenm lal ehtt:rgoe
= t(lioirbybap of add begni )carierr * b(ltypbiioar fo add agisnsp no sdeseia e)allle * tilrypbaiob( fo mom nebig iarerr)c * (piyotlibrba fo mmo snspgia no esisaed l)ealle
=
2/3 * 2/1 * 1100/ * 2/1=
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