naMidnlea s:Gneeict
Man sha /23 chnace fo iengb a raeir.cr (eH eods nto heav eth eea.dssi) W maon aerricr sirk utsm eb uacldaltce tiwh 2^p + 2pq + 2q.^ 2q^ = 01/,0400 q = 0/2,10 p si yguhlro = 2 p1q = 110/0 = arrCrie eecnfuqry .
ksRi of vhagin a cdhil uhst usleaq 23/ x 110/0 x 4/1 = 0/601e/ cu2:3Bse a = Man rierCra rsik 1 /001 = maleFe iaerrCr 4/R1i ks = heancC hety heca psas on eth recsievse egne to tehri .fisfnpgor
Thsi eht mase as yspyeko'@mnac ilxaaonpnte hitw roem piletnnxoaa teohs hatt ende .it..
Teh aetitnp is fteefaudnc yb hte tcrialprua autslooma vesscerei eisedas adn sih rhtbero hsa eth saalouotm vseisreec eadisse t--&g; tsih aemsn aceh of rhtie sptearn casrier het RA lel.lae No,w rfo het eatintp to eb eceftanudf nevig htta hotb ihs astrpne heva het AR eel,all it mnsae ttah eth tnaietp sha a /23 chance ttah eh si lomsuiaylneust ndftceafeu dan a cairr.re
hTe pita'sent ernpatr si dunfeacetf adn malonr riyg-WneaHredb gtsnceei (sa dastte in eht epmobe.rh.l)wn ihts is iafslpycciel ,neontdeim you rae ot essuma atth eht errpant ash a arcrire eufnqcyre rof eht RA ellael, hcwih queal to 2qp.
ehT sdeasie ash a rceyenfqu in teh lipuaptnoo fo 14.000/0 siTh is ^q2 &-t-;g 2q^ = 1/.40000 ilgoSvn ofr q, uyo teg q = 102./0
eirarrC enfeqyurc si .qp2 vrweoeH, rof a erra ,asieesd qp2 ≈ .2q ,So the arirerc yferceqnu orf het trrnpea = 2q = 2 * 1/002 = /10.10
wo,N teh Q akss aoutb na fgoprinfs fo teh eitnpat nda his aertnrp iegbn dcetffea, os to avhe na faceeftd ,idchl eerth is a /14 ahncce fo hiagnv an caedftfe cilhd ubaseces( teh entipta nda het arnrtep tboh aevh a 1/2 ahencc fo aipnssg teh aeelll t-;&g- uoy lmpietul hseet htrogeet /21 * /12.)
So, ypillmtu 3/2 * 1/100 * 14/ = ./0160 hTsi is eip(tatnP geinb a recirar) * rtepr(anP nigeb a )eirrrac * ahnvi(Pg na ecetdfaf offpngsri o)hrgetet.
hTe iiybtlrobap of hte fethra igenb a cerrrai is 23/ cesni it is owknn ahtt he eo’tsnd haev eht iedseas. ehnT eht ipobyrtliba of hmi snpaigs it no ot hsi kid s:i
2/1 * 2/3 = /31
tWih eth gn-dareirybeWH cP,reilipn uoy nca fgeiru otu hte biirbaltypo fo eht treomh enbgi a a:reirrc
q = )0qs(0r,1t04/0 = 00/12
S,o 2pq = 2 * 201/0 * 1090/29, hwich papxor si 0110,/ nda teh paobiyltirb of eth hdcli nggttei sthi eaelll si 100/1 * /12 = 0012/
su:hT
12/00 * 3/1 = 10/60
hwy rhtee is ylribtaopib fo hferat gbeni a arcrire is 23/
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49oallutnaCics for dad. The ibtlapirboy of het tarfhe beign a arrceir si 2/3 iencs ti is nkonw atht eh snoetd’ heav eth dsesa.ie nThe teh obitriaplby fo ihm nisgpas ti on ot hsi ikd is /,21 usth:
aullsaoinctC for omm. tWih hte drireg-HayeWnb rnPl,eiicp uoy nac frieug tuo eth oyabiptlirb fo the thermo enigb a rr:ecira
q = 0rts0140),(0/q = /2100So,
p2q = 2 * 01/02 * 19/9200, hhcwi is pxrpao 1.1/00roF hte ichld ot teg hte llaele from mo,m wto nigtsh ndee ot p:eapnh 1)( mom umts be a icrerar rgee[”zthoo]ty“e nad 2() omm umts spas hte leelal ot h:ilcd
uitnPg ti lla htteoegr. w,No emconib all erg:httoe
= otyibi(brapl of add nebig r)cerari * tly(aipbbiro fo add agssnip on seiades le)lale * b(ioliryaptb fo mom bnieg ic)rearr * iybialorbt(p of mmo npssgai no sedsiae lale)le
=
32/ * 12/ * 10/01 * /12=
1 in 006$279$49