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Retired NBME 22 Answers

nbme22/Block 2/Question#34 (reveal difficulty score)
A 30-year-old man and a 24-year-old woman ...
1 in 600 ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +27  upvote downvote
submitted by โˆ—drdoom(1206)
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lcsaCunloita for dda. The lioapbrbiyt of hte etarhf bngie a acerirr is 2/3 senci ti si nwnko htta eh sdenoโ€™t heva the seadsi.e hTne het oritlibaybp fo him snspiag ti no ot sih ikd si 21,/ :thus

  • tbiPiboayrl of dda gbeni caerrri = 32/
  • bribaolPtyi fo dad gsinspa no sideeas elalle = /12

uliacaCntols rof mmo. hitW eht gWaHb-nyriered rPnii,pcel you cna gifrue otu eth btbipailroy of eth toemhr neibg a aer:irrc

q = sq410,/00)t(0r = 00/12

o,S q2p = 2 * 200/1 * 02/9019, wcihh is opaprx 01/.10

For hte lichd ot get het lelael fmor ,omm tow sntghi eend to npph:ae 1() mmo tmsu eb a crreira zt[eeegyt]โ€ohโ€œor dan (2) mom msut spsa het ealell ot icldh:

  • aPrlyoibitb of omm nebig airercr = 1/010
  • iioraybPtlb of mom ssipang on sesdiea llleea = 12/

iuPngt it lal rgeeotth. ,owN nbeiocm all oetghte:r

= lory(tbiabip fo dad bgein riercra) * tibaboiylrp( fo dad ngpasis on ssdaiee lalel)e * pbiytlroaib( of mom gnieb rar)icer * (iapybotbril fo mom sainsgp no aeissde e)leall

= /32 * 12/ * 0/110 * 21/
= 1 in 600

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kernicterusthefrog  oT ueqot gohTyr orhT, argd uenq:e e,"w Jesus, os"sgr +52
niboonsh  hsTi nostiequ sakme em ntwa ot voitm +14
drdoom  lol +
5thgencephalosporin  kyoa wwo +
tekkenman101  You cna meka hsti a tlo kuecriq yb snigu selipm selur rfo umotaoasl esrecsvie ds.se asi)1e endffUcaet rnepat ihwt cadfeetf lngeeia llwi be a ecrrria 23/ fo eht teim 2 )aA)( curynfeqe in iloppntuoa si esupr owl os oyu nac roinge P and tjsu use 2q)( in rreod to caceutlal eicarrr u.crfeqeny oS kate teh quraes orot of hte homzoosuyg ecsvrsiee fqneryuec 0,1(0)040/ adn tujs gplu it ni: .(500)2 = . )130 hTe sodd fo ehrit cildh niegb tafdefec thwi teh otw enstpra ibeng ussdaem tcetioyhlhpa racsirer is 1/4 a)a( or d.52.sD 'a rrareci ncehac 32/)( x oMm's reiacrr nehcca 10)(. x hlis'cd neacch fo nbieg rscieevse 5()2. +1

Instead of doing all those calculations for the mom, you can also just multiply the dad's probability by 1/200 โ†’ q, the probability of the allele in the general population

+1/- hungrybox(1277)


 +4  upvote downvote
submitted by โˆ—keycompany(351)
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aanindMel sieeGtn:c

anM hsa 2/3 chaenc fo enibg a rricaer. He( dose ont vaeh hte sesdia.)e onmaW arerirc riks ustm eb eccullaadt wtih p^2 + 2qp + .^q2 ^q2 = 410000/, q = 0,02/1 p is grluhoy = 21qp = 00/11 = rraerCi yeeuqnrcf .

Risk fo naghiv a dhlic hstu asuleq 3/2 x 01/01 x 4/1 = 10/06c 3eaBe/2 :us = Mna ierraCr krsi 0 /101 = Fmeela rrrCaei 1s /Ri4k = cehanC ehty chae spas on the esrveisce nege to trhie ornf.isfgp

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hello  eeS my nitopelnxaa if yuo ende mroe oswdr ot nxelpia sith axeolniatnp +2



 +3  upvote downvote
submitted by โˆ—hello(429)
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hisT hte same as o@enkampyycs' apeoinxalnt ihwt meor iaenatoxlpn sehto htta eden .it..

ehT neiattp si ffudeanetc by het arupitclar atuomaosl vseisreec seidsae dna hsi rbeohtr ash teh aouasolmt vriceesse aisedse ->-; hist mnaes each fo tehri sraentp rarices het AR leel.al Nwo, rfo the ipnatte to eb entufdafce ignve ttah thob ish ntparse vhea the AR aellle, ti manse ahtt eth ptaneti hsa a 23/ hecnac thta eh is yeslunaitsuolm afndfectue adn a eirrrca.

ehT eatintp's renrtap is ueteffancd dan namlor bydn-raWegeiHr eseitcng (sa taestd in het o.ep.el)hmbrnw sith si sclpaiyecilf modneen,it uyo rae ot uessma ahtt teh ptnrrae hsa a iraecrr eneyfrucq for het AR leela,l hicwh ealuq to q.2p

ehT dsiesea ahs a reecuyqfn ni eht taloouipnp of 000.410/ ihsT si ^2q g;&t-- 2q^ = 00/4.010 lSvnigo rfo q, yuo etg q = .1/200

eraiCrr ycefreuqn si .2qp Heevowr, fro a rear de,sisae pq2 โ‰ˆ 2.q ,oS teh iracerr erfnceqyu ofr the paertrn = q2 = 2 * 012/0 = .01/01

,wNo teh Q sksa utaob an sfpirognf of hte iptanet dna ish arretnp bgnei ffeatcde, os to haev na cedafetf ci,dlh hteer is a 14/ cechan of haivgn an cadeteff hclid cu(esbesa the tpaient nda hte nptrrae obht heva a 12/ cahenc fo sipsagn the llelae g--&t; ouy iletpmlu eseht terhotge 12/ * 2/).1

,oS iymlutlp /32 * 0011/ * 14/ = 06/.01 ihTs si teaPnpi(t bieng a ericra)r * tarrnPep( ebgin a rir)raec * ni(avPhg na tdeefacf frfsipnog )tgo.three

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 +0  upvote downvote
submitted by beastfromtheastx(0)
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ehT bpiyibtrloa fo eht aterfh bgnie a ceiarrr is 2/3 nisce it is okwnn ttha he seoโ€™tnd vhae eth .dsaeies Thne hte plbobirtyai of mhi pgainss ti no ot hsi ikd s:i

12/ * 23/ = 13/

ithW teh Wdgy-ierbHarne ,clenPipri uyo anc gfurie otu eth ipatoibylrb fo het tomrhe bgine a rcearir:

q = rt01,)qs4(000/ = /0210

oS, 2pq = 2 * 10/20 * /900921, chhiw praxpo is 001,/1 dna het yialtipobrb fo het chdli inegttg isht aeelll si 0/011 * 2/1 = 210/0

husT:

0/120 * 31/ = 0/106

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brill45  uoY did this thrig but I tknhi edma it a tib moer pelcodmtcia ahtn deeend ot e.b oT igrfue tou teh odoliikhel of a raomnd npeosr in eth ppuatoloni sspinag on a cievesser lealle, oyu tujs deen ot do aq)usorteq(or2 to gte ot q. Adn tujs seu htat q ot mpllityu itwh het /13 uyo gto rareil.e Teh q elvua lslet ouy hte lalele nqcyufere ni eht aopu,tliopn hrteehw eth noersp is a recirar or oozmgoushy sceveeirs .otbh You lslti tog i,t utb sjtu eniltgt you wnko hte rieaes oruet ni csae yuo ees it igaa!n +2



 +0  upvote downvote
submitted by kdckjn(0)
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yhw rheet si yitblpbriao fo hatfre bieng a eicarrr is 2/3

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drdoom  eW ssaemu itsh is a iveessecr .dsisaee nI ehort wdrs,o uyo taifemsn hte esdisea if you htineri a asdesei ea,llel ,d mofr ryou trehmo and a aedsesi lal,lee ,d rfmo uory ,arehft ggnvii uyo na eaelll nagiipr etedond by .dd dd = uyo vahe eht a.esdies heT ratfeh sdeo not veah eth e;dsasei iths naems his eenpygto anc ylon eb 1 of rehet h:tgnis DD, ,Dd ro dD. Tath ,si DD = D mofr ihs dda, D orfm ihs ;mmo Dd = D rmfo ihs d,da d frmo hsi m;mo or dD = d mrof his ,dda D rfom ish .mom oeicNt hatt ni nylo tow fo hetse 3 sisibieipltso esod hte treahf l)tyetaiol(np avhe a esdieas lleale d() that he timgh assp no ot sih g.onyrpe +

We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by โ€œdd โ€).

dd = you have the disease.

The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.

That is,

  • DD = D from his dad, D from his mom;
  • or Dd = D from his dad, d from his mom;
  • or dD = d from his dad, D from his mom.

Notice that in only two of these 3 possibilities (โ…”) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.

+1/- drdoom(1206)


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