aanindMel sieeGtn:c
anM hsa 2/3 chaenc fo enibg a rricaer. He( dose ont vaeh hte sesdia.)e onmaW arerirc riks ustm eb eccullaadt wtih p^2 + 2qp + .^q2 ^q2 = 410000/, q = 0,02/1 p is grluhoy = 21qp = 00/11 = rraerCi yeeuqnrcf .
Risk fo naghiv a dhlic hstu asuleq 3/2 x 01/01 x 4/1 = 10/06c 3eaBe/2 :us = Mna ierraCr krsi 0 /101 = Fmeela rrrCaei 1s /Ri4k = cehanC ehty chae spas on the esrveisce nege to trhie ornf.isfgp
hisT hte same as o@enkampyycs' apeoinxalnt ihwt meor iaenatoxlpn sehto htta eden .it..
ehT neiattp si ffudeanetc by het arupitclar atuomaosl vseisreec seidsae dna hsi rbeohtr ash teh aouasolmt vriceesse aisedse ->-; hist mnaes each fo tehri sraentp rarices het AR leel.al Nwo, rfo the ipnatte to eb entufdafce ignve ttah thob ish ntparse vhea the AR aellle, ti manse ahtt eth ptaneti hsa a 23/ hecnac thta eh is yeslunaitsuolm afndfectue adn a eirrrca.
ehT eatintp's renrtap is ueteffancd dan namlor bydn-raWegeiHr eseitcng (sa taestd in het o.ep.el)hmbrnw sith si sclpaiyecilf modneen,it uyo rae ot uessma ahtt teh ptnrrae hsa a iraecrr eneyfrucq for het AR leela,l hicwh ealuq to q.2p
ehT dsiesea ahs a reecuyqfn ni eht taloouipnp of 000.410/ ihsT si ^2q g;&t-- 2q^ = 00/4.010 lSvnigo rfo q, yuo etg q = .1/200
eraiCrr ycefreuqn si .2qp Heevowr, fro a rear de,sisae pq2 โ 2.q ,oS teh iracerr erfnceqyu ofr the paertrn = q2 = 2 * 012/0 = .01/01
,wNo teh Q sksa utaob an sfpirognf of hte iptanet dna ish arretnp bgnei ffeatcde, os to haev na cedafetf ci,dlh hteer is a 14/ cechan of haivgn an cadeteff hclid cu(esbesa the tpaient nda hte nptrrae obht heva a 12/ cahenc fo sipsagn the llelae g--&t; ouy iletpmlu eseht terhotge 12/ * 2/).1
,oS iymlutlp /32 * 0011/ * 14/ = 06/.01 ihTs si teaPnpi(t bieng a ericra)r * tarrnPep( ebgin a rir)raec * ni(avPhg na tdeefacf frfsipnog )tgo.three
ehT bpiyibtrloa fo eht aterfh bgnie a ceiarrr is 2/3 nisce it is okwnn ttha he seoโtnd vhae eth .dsaeies Thne hte plbobirtyai of mhi pgainss ti no ot hsi ikd s:i
12/ * 23/ = 13/
ithW teh Wdgy-ierbHarne ,clenPipri uyo anc gfurie otu eth ipatoibylrb fo het tomrhe bgine a rcearir:
q = rt01,)qs4(000/ = /0210
oS, 2pq = 2 * 10/20 * /900921
, chhiw praxpo is 001,/1 dna het yialtipobrb fo het chdli inegttg isht aeelll si 0/011 * 2/1 = 210/0
husT:
0/120 * 31/ = 0/106
yhw rheet si yitblpbriao fo hatfre bieng a eicarrr is 2/3
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by โdd โ).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (โ ) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by โdrdoom(1206)
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lcsaCunloita for dda. The lioapbrbiyt of hte etarhf bngie a acerirr is 2/3 senci ti si nwnko htta eh sdenoโt heva the seadsi.e hTne het oritlibaybp fo him snspiag ti no ot sih ikd si 21,/ :thus
uliacaCntols rof mmo. hitW eht gWaHb-nyriered rPnii,pcel you cna gifrue otu eth btbipailroy of eth toemhr neibg a aer:irrc
q = sq410,/00)t(0r = 00/12
o,S
q2p = 2 * 200/1 * 02/9019
, wcihh is opaprx 01/.10For hte lichd ot get het lelael fmor ,omm tow sntghi eend to npph:ae 1() mmo tmsu eb a crreira zt[eeegyt]โohโor dan (2) mom msut spsa het ealell ot icldh:
iuPngt it lal rgeeotth. ,owN nbeiocm all oetghte:r
= lory(tbiabip fo dad bgein riercra) * tibaboiylrp( fo dad ngpasis on ssdaiee lalel)e * pbiytlroaib( of mom gnieb rar)icer * (iapybotbril fo mom sainsgp no aeissde e)leall
=
/32 * 12/ * 0/110 * 21/
=
1 in 600