eaalnnMdi ince:Gset
nMa sah 2/3 encach fo inbge a rcreari. H(e edos not ahve teh ).sasedei ao mnW irarecr kris mtus eb adlcteluca whit 2^p + pq2 + q2.^ 2 ^q = 401/0,00 q = ,/2100 p si oulyhgr = q2 1p = 10/10 = erCrari ueeyrqcnf .
iskR fo ihnvag a idlch usht laqseu 32/ x 1/100 x /14 = /0160 ecB2u:e/ a3s = naM erarCri krsi 101/ 0 = Felaem irCrrea 4 sRki1/ = haeCcn etyh echa saps no eht iveescser ngee ot hetri rgifonfsp.
siTh the aesm as ke@acpom'syny inletxanpao htiw mreo atpxiolnnae soeht htat need .t.i.
Teh attneip si dntaeuceff yb teh raluipctra tmoaousla ercisseve adseies nda his brhreot hsa teh otumaaols esisercev sisaede t;g-&- tihs seanm hcae fo ihter srpntea easrrci hte RA e.llela wNo, rfo teh itpntea ot eb eatceufdfn ngevi ahtt hobt his pnsrtea veah teh RA lee,all ti nmesa htta eht npteati ash a 32/ cneahc ahtt eh is ulioamusltnesy nffcdeetua nad a a.rierrc
heT tt'sniaep atreprn si enefafctud dna ralonm dWeiryb-raHgne gceesint as( dsteta ni eht e)nlp..whobmre ihst si fiecllsyacip ,otenienmd uoy rea ot smeasu htat teh rneptar sah a rreacir feyecurnq for the RA le,alle wchhi eaulq ot q.p2
ehT easiesd sha a euycrfqne in hte utpoanploi of 104./000 hTsi is 2^q -&-tg; ^2q = ./100004 Signvol rof q, uyo etg q = 10./20
eirarrC uecqryenf is q.2p eHrveow, rof a raer siad,ese p2q ≈ 2.q o,S teh erircar rnyfecqeu rfo the trenrap = q2 = 2 * 02/10 = 011./0
N,wo hte Q saks tabuo na pfsirogfn fo eht piteatn dan hsi rapenrt gbien tcfafdee, so ot eahv na aeedtffc ,dihlc ehtre si a 14/ aecnch fo vhnagi na ffactdee lchid euaec(ssb eht paitnte dan teh ntaeprr tboh haev a 21/ achnce of piangss hte aellel g-&t;- uoy pelmltui teehs ettgoreh 21/ * .1)/2
,oS utiyllmp 32/ * 0/110 * /41 = /00.61 isTh is ePpta(nti eingb a )rrreica * e(Praptnr ebngi a irerrac) * n(vghaiP an effadetc fopfgsrni hr.ott)eeg
heT iayltobbipr of hte hreaft beign a rarerci is 23/ iscne ti is wnnok hatt he deot’sn hvae het s.eeaisd Tehn teh taroiblybip fo hmi gsinpas ti on to his dik :is
2/1 * 2/3 = 1/3
Wtih hte brnieHadWr-eyg ir,Pilpecn yuo nac uerifg tuo het oprabtiiybl of the emotrh being a :icearrr
q = )/41,q0t0r0s0( = 0/210
S,o 2qp = 2 * 010/2 * 010992/, hhicw oxrapp si 100,/1 nad het ipilbytraob of teh lcidh igetgtn hsit lallee si /1010 * 1/2 = 1002/
:ushT
0012/ * 13/ = 6001/
yhw erhet si aytiilorpbb fo tfaehr nebgi a rrecira si 3/2
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49ulCastlniaco orf dda. Teh ltybiobprai of eht etrahf gienb a rreraic is 3/2 nsice ti si nknwo htat eh sedton’ haev hte .seesdai hnTe het raotbibpyil fo him aspnsgi it no to ihs idk is ,/21 u:tsh
aCtonasciull fro mmo. thiW eth dnraWir-ygbeHe rnlPc,ipie yuo nac ruefgi out eht paorbilbity fo eth ehmtro nbieg a errr:aic
q = 4),0tsq0r/100( = 021/0o,S
2pq = 2 * 21/00 * 20019/9, hhwic is opraxp 1/.010orF the dhicl to gte eht aellle romf om,m wot hstgni nede ot :nhppea )1( omm stum eb a ercriar geotzre“thyo[”e] and 2() mmo tsum psas eht lelael to dli:hc
ginutP ti lla rgeteoht. w,No oniecbm all :thgetore
= bailpyotir(b fo add egbin rrrie)ca * otbyliiprba( of dda npsgias no essidea lea)ell * pbr(iyibalot fo mom gibne rcr)eari * (riiolbbyapt of omm pniasgs on isdeesa lee)lal
=
3/2 * 21/ * 10/01 * 2/1=
1 ni 600$279$49