adaiMlenn isetGnc:e
nMa sha /23 cahcen of nbeig a r.cirear eH( odse not heva het sdsi).eae namo W rerraci skri tums be altcladceu ihtw ^p2 + 2pq + .^q2 q^ 2 = /000041, q = 0/021, p si rhygoul = pq 21 = 010/1 = rarrieC ercfeyunq .
iksR of ghainv a clhid usth selqau /23 x 010/1 x /14 = 10/60c3e:2Bse u/a = Man rirearC krsi 00/1 1 = maFeel erriarC k4si1/R = hnaecC they hace asps on eht essecirev nege ot ehrit gfn.sfpior
sihT hte emas sa @opay'cskmyen ontaaplixen htiw ermo npeinltoaax seoth ahtt ende .i.t.
ehT tpenati si nufatfeecd yb eht calarrptiu mosaoutla evcirssee aeiedss dna ihs rroebth sha the laootmuas siscrveee edasesi &g-t-; isth amesn aehc fo teirh anrtpes aecrisr hte AR elll.ae wN,o rof hte patneti to eb edacfnfeut eving tath tobh ihs nsetrpa vhea the AR lalle,e ti emsan ttah hte taipnet has a 32/ hceanc hatt eh si msytuoialenslu deeuffncta adn a ir.rraec
The espitta'n etaprrn si adtfnefuce nad romlna -reierygWndHab eenctsig sa( atsetd in eth .rmw)ne.beophl tsih si felcscypliia onen,itdme uoy rea to aemuss hatt het pnerrta has a rreraci cefnueyqr rof hte RA ,leaell hicwh elqua to 2p.q
The edesias ash a qneceufry ni het npplouotai fo 1.00/004 Thsi is ^2q gt-;&- 2q^ = 001/.004 gnvlioS fro ,q you get q = 201/.0
Crreari yunrceefq is qp.2 reveoHw, rof a rera ,ieaedss 2pq โ .2q o,S eht iarrcre ncufreyqe rfo eht rneaprt = 2q = 2 * 2/001 = 10/.01
,wNo the Q ksas tobau an sofinpfgr fo het ipnteat adn ish atrrenp geinb fetadefc, os to veha na effcetda hl,dci eetrh is a /41 echnac of ingavh an faedtcfe lihdc scubsaee( the etnpiat dna eth nrpetra thbo ahev a 1/2 chacne fo gaspnis the lelela g&;--t uoy uielpmtl tsehe ttrheoge /21 * 21)/.
o,S ilyulmtp 32/ * 1/001 * 1/4 = 16/0.0 This si atet(ipnP iengb a ir)cerar * p(terarPn bieng a )aerrcri * hngiv(aP na teecafdf iffprgnso r)hgotete.
ehT obapiiblryt of the aehftr egnib a eciarrr is 2/3 eisnc it si known ttah he eโtndso ahve eth s.aedsie neTh the arlibpbtioy fo mhi saipgns it on ot sih kdi i:s
/21 * /23 = 3/1
tWih teh nirdgreHayeWb- n,icrepilP ouy cna grufei uot eht obatbrypiil fo eht mrtheo ebnig a aicrer:r
q = t,(41q0s00)r/0 = 020/1
oS, 2pq = 2 * 020/1 * 900192/, hhciw xrpapo si 0,110/ adn eth ltbipboyari fo eht ilhcd ttiggen this llleea si 11/00 * 2/1 = 1/020
usTh:
10/20 * 1/3 = 6010/
hwy rtehe si ibbrtylpaio of hfeart bgein a irrcrae is /32
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by โdd โ).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (โ ) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by โdrdoom(1206)
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$279$49uaioltCscanl rfo dda. hTe rpiyabiobtl fo eth rhfeat enbig a iacrerr is /32 cisne it si nokwn htat eh oedntsโ ahev the a.edessi ehnT eht iploatibryb fo ihm gnsspia ti no ot ish dik is 2,/1 :suht
acloCtaunlis orf mmo. Whti het neWig-redHybra irPp,iceln yuo anc ieurgf out hte bilyirapbot of teh ehtmor binge a acrrre:i
q = 4t)(sr00,10q0/ = 02/01oS,
2pq = 2 * 2100/ * 9/01920, iwhch si paorpx 01./10Fro teh hlcdi ot get the ellale form mo,m wto sthngi ened ot n:appeh 1() omm stmu eb a erairrc et[oztgyre]โohโe dna )(2 mom ustm sspa eht aeelll to i:dlhc
Pigtun it lla tegeothr. ,Nwo ibomnec lal :rgohttee
= bayti(biorlp fo dda negbi raie)rrc * tbryilaobpi( fo dda ssigapn no seiadse llal)ee * orpblbiati(y of mom ebgni rri)rcea * blrpiyot(aib of mom snapisg on sdeasie aellel)
=
23/ * /12 * 01/10 * 1/2=
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