aMenldnia :isetGecn
anM sah /23 eacchn of ngebi a acrrir.e e(H sedo not veah the e.eds)ais moWa n reirrca kris tsum be eclctaldau hwti 2p^ + 2pq + .2^q ^ q2 = 00/,4010 q = 1,0/20 p is hrulgoy = 1q 2p = 1/010 = arCrrei cruefqney .
Rkis fo iagnhv a hclid usht aqsuel /23 x 101/0 x 41/ = 1/0062:eBs/ua3c e = Man earrrCi ksri 0011/ = leaFem ireaCrr 4R1ik/ s = caCneh ehty aehc assp no het vecsirees egne to ihrte pfognif.rs
hsTi eht saem sa pyo@seamy'cnk inpxatnaeol hitw mero nitolnexaap seoht taht edne .i..t
hTe ntaipte is fteefudacn yb hte acrarlupit luaoosatm csrseieev aiessde nda sih brhorte sha het osloaautm rsceivese sieased -;&-gt shti nasem hace of ierth eapsntr rrasiec eth AR ella.le oNw, ofr teh naittpe ot eb fafcndeteu enivg htat htbo sih asetprn vaeh the AR laell,e it nsmea taht eth pnaeitt ash a 3/2 hcaenc hatt he si ilyeusoalunsmt fdfecetanu dna a rareir.c
ehT 'iastenpt apntrre si uenecdffat adn loranm riWbnaeydeHg-r ectsinge a(s aedtst in eth .mo.pnh)rebewl stih si elciflsyacpi ,ndmeiteon uoy rea ot mseaus ttah teh terranp ahs a errirac fcnqeyrue fro teh RA lelea,l hchiw aquel ot q2.p
Teh aeiesds sha a enfreyuqc in eht atuploiopn of 0./10004 Thsi is ^q2 tg;&-- 2q^ = /04000.1 violngS rof ,q yuo egt q = /.0012
iaerrCr erencyfqu si .qp2 oeHrwev, rfo a aerr d,seaesi 2pq ≈ q2. ,So eht erriarc feycnrque for eth raptner = q2 = 2 * /0021 = /1.100
ow,N teh Q kssa oatbu an fgpsniorf of hte ptetnia adn his rrteapn iebng tdefefac, os ot eavh na cfdefeat hldci, treeh si a 41/ enchac of vnigha na cedatfef ldcih (sbaceuse eht ettainp and teh rearptn tobh ehva a 2/1 accenh of spagsni the ellale -g-&t; you euiltlpm sthee eertotgh 1/2 * ./)12
o,S lyptluim 3/2 * /1001 * 41/ = 0610./ shiT is (eapniPtt enibg a rieacrr) * (rpnrPeat ebing a crea)rir * (iagvhnP na ftedafec nsffigrpo rht)gt.oee
Teh albyorpitib fo het efhart gebni a crrraei is 2/3 nsice ti si wknon tath he sde’ton veha eth eassie.d Tneh teh oibatpribyl fo him psgasin ti no ot ihs idk s:i
/12 * 23/ = /13
iWth het rnHib-Wgereayd p,licreinP oyu can ufegri tuo eth oibltybiapr fo hte rtomeh neibg a recri:ar
q = 04t(/0r,)0sq01 = 0/120
S,o 2pq = 2 * 01/20 * /009129, ihhwc oparpx is /1100, nda het batipobirly of teh ilhdc ttegngi shit ealell is 01/01 * 21/ = 002/1
h:sTu
0/201 * /31 = 610/0
why eerht is rptaobiibly fo fhaert ngbie a rearicr is 23/
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49tousllnaaCic rof dda. eTh ptbilbrayio fo eht hafret inbge a carrire si /32 ncesi it si wnnko taht he te’dsno aveh eht dia.sese hnTe teh lobirtapiyb of him ssngipa ti on to shi dik is 2,1/ uhs:t
Coctsaaillnu rfo mom. ihtW the neyrea-rHgdWbi pnPieilr,c you acn urefgi uto hte aiopbritbyl of eth tmeroh ienbg a :cerarir
q = 1q)04(r0t/,00s = 002/1S,o
2pq = 2 * 00/12 * 91/0029, ichwh si rpxopa 1010/.Fro het dhcil to egt eth lleela rmof mom, otw ingths dnee to ae:ppnh ()1 mmo muts eb a rrrceai otetze[]eg”“rhoy nad ()2 mom tusm sasp het elelal ot cdlhi:
itgnuP it lal oethrteg. wN,o ebomnic lla reh:ttego
= olbaybirt(pi fo dda ngibe iea)crrr * a(tbyoilripb fo dda iasgnsp no saeides lle)ale * pilbyrbio(ta fo mmo bgnie icerrar) * boiy(tapibrl of mmo psigsan no disseea lle)lea
=
/23 * 1/2 * 00/11 * 2/1=
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