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Retired NBME 22 Answers

nbme22/Block 2/Question#34 (reveal difficulty score)
A 30-year-old man and a 24-year-old woman ...
1 in 600 🔍 / 📺 / 🌳 / 📖
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 +27  upvote downvote
submitted by ∗drdoom(1206)
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tlsauilaConc orf add. ehT pablibytori fo the ferhat bgnei a carerri si 2/3 eincs ti si wnkno htta he n’oetsd hvea het as.sedie nheT teh boitilpyarb of him pgnssia ti on ot hsi dki is /,12 shu:t

  • obPbitilray of add eibgn crrirea = /32
  • loiatiybPrb of add gssapin on adesise lllaee = 1/2

canoltuisaCl orf mom. iWth eth erdnyHb-argWei Prceiinl,p you nac irefgu out teh triyopblbia of hte hterom ibegn a r:racrei

q = )0/4rs000(tq1, = 2/010

S,o 2pq = 2 * 0021/ * 0120/99, ihwhc is xrapop 10/10.

rFo het hcild ot get the eelall fomr mom, wot tsnhig eend ot p:neaph )(1 omm utms be a ciaerrr ezt“]”yot[regohe nad )2( omm sutm sspa teh aleell ot d:hicl

  • otibyrPibal fo omm begni rraicre = 1/001
  • yrboPtiabli fo omm anpsisg no sasidee eallle = /12

igPunt ti lla teeorgth. o,wN bniecmo all e:ethorgt

= ltb(roiaiybp of dad nebig acirrre) * bilty(iorbap of add sspangi no iseedsa le)lale * bboai(iltpry fo mmo begin rrric)ae * lbiayt(pbiro of mom agsnpis no essaeid l)lelae

= 2/3 * 21/ * 1010/ * 1/2
= 1 in 600

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kernicterusthefrog  To equot hgyroT ,rTho rdag :euqen ",we seJus, sr"ogs +52
niboonsh  Tsih nsqitueo ksema em tnwa ot vtiom +14
drdoom  llo +
5thgencephalosporin  yoka wow +
tekkenman101  uoY can emak isth a tlo qrukice by siugn spimle resul orf olaosuamt rvieseesc es)sids.1ea eenfadtUfc pneatr whti cfeftdea elegnai wlli eb a ceirarr 32/ of eht imte 2)) (Aa eruqeycfn ni pitlonpuao is surpe owl os ouy cna gioner P nad ustj use 2)(q in rerod to ctleaaucl arcreri nqecryeuf. So atek hte qseaur oort fo het gyoumoohzs vsrcsieee yreuqfcen 10/(04)0,0 nda sjut plgu it n:i 520(0.) = 0 .)31 hTe dsdo fo rethi lcdhi engbi fefaetdc ihwt hte two sartpen iengb aedussm hlchittpoyae arrcisre is 4/1 a()a or sd5 a'..2D crriare echcan (2/3) x om'sM rrierac cnahce .()10 x icdlsh' ncheac of ibnge rceevsesi 2).5( +1

Instead of doing all those calculations for the mom, you can also just multiply the dad's probability by 1/200 → q, the probability of the allele in the general population

+1/- hungrybox(1277)

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 +4  upvote downvote
submitted by ∗keycompany(351)
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nalaeniMd ist:ecGen

aMn hsa /32 haccne fo enibg a a.eicrrr (eH osed otn veah eth sseiae).d oWa mn riacrer ksri tums be latcdeaclu htwi p^2 + 2qp + .^q2 q ^2 = 0,/00410 q = /0012, p si rulgyoh = q12p = 110/0 = errrCia cyrenefqu .

skiR fo ahvnig a dcihl hust eqsalu 2/3 x 10/10 x 14/ = 1006/ cse:au2/e 3B = aMn raiCerr irks 101 /0 = leFema Cearrri 4is1/Rk = cCnhae thye ceha sasp on hte ecirseevs eegn ot hiter rnoip.ffsg

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hello  eeS ym tnnaiaxloep fi oyu ndee oemr dwrso to xipnlea hits naiepoxantl +2


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 +3  upvote downvote
submitted by ∗hello(429)
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ihsT the saem as @ykpe'osanycm annexiptloa hitw omer eaxapnnitlo hsoet taht need .t..i

The ipatnte si dntfceauef yb het claitrrpua osatuloma ssrcieeve iasdese and his htrrbeo sah eht aalutoosm ericeevss sdiseea t-&g;- itsh asemn ehac of iehrt trnepsa reasric teh AR l.eleal oNw, rof het tintepa to eb enefdftcua vigne ttha obht hsi prsaent have eht RA eel,lla it aensm htta het ttpnaie ash a 3/2 haeccn htat he si aunmlsyoetuils fedfautecn and a .rerrica

hTe iets'tpna nrarpte is eenffdautc dan monarl Webergay-dHirn esicengt as( adttes ni eht .opern.emhbw)l hist si fclyaciipsel nemdieto,n uoy are to aemuss htta teh pearntr hsa a iercarr qfncueyer ofr het RA leae,ll ihwch queal ot p2q.

hTe esdieas ash a eufyceqnr in hte lupiotpnoa of 10400./0 sihT si ^2q ;t-&g- 2^q = 0.4100/0 Snloigv ofr ,q oyu teg q = 02./01

arrCeir nuycefeqr si q.2p Hovewre, rof a rrae siedea,s qp2 ≈ 2q. So, eht racreri cyequrfne rfo eht taperrn = q2 = 2 * 0021/ = 10.10/

,woN the Q sask obtau an pfgronsfi fo teh nitpaet dna ish rrptaen nbige ectdffea, os to vahe an tefdface lc,hdi theer si a 1/4 ncceah of ganihv an fedcetfa hclid uc(ssabee teh etntipa nda eth neatrpr btoh have a /21 ceahcn of paissgn het lellea g-t&-; uyo iltmelpu ethes orghteet 1/2 * .1)2/

S,o lyupmilt 3/2 * 00/11 * 1/4 = 0./160 hisT is n(tPtaiep being a irr)race * P(atnrrep niebg a e)irrcar * vnigPa(h na tdeacffe figsoprfn gte.teohr)

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 +0  upvote downvote
submitted by beastfromtheastx(0)
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ehT ypartiilobb fo hte hfater benig a ricrrea si /23 iencs it is ownkn atth eh onest’d aveh het iedessa. hTne het obliarbypit of hmi gnipsas it no ot sih dki i:s

2/1 * 23/ = /31

Wthi eth nHW-aiereybgdr pcinel,Pri yuo nac euigfr otu eht oriybiatplb fo teh tmeorh bgeni a rerraci:

q = /0q,0s04)t10r( = 102/0

So, q2p = 2 * 2100/ * 9120/90, hwcih opxrpa is ,0/011 nad the bbaytoplrii of teh dhicl gtigten stih aleell is 1/001 * 12/ = 1020/

hT:us

/1200 * 31/ = 001/6

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brill45  oYu did itsh irtgh ubt I kinth eadm it a bti roem tdecipcalom anth deeedn ot e.b To euigrf otu eth ieollhokid fo a nrdoma erpons in eht ptaolpouin ignsaps no a veesicres ,llaele you sjut deen ot do ruqqe)2(straoo ot teg to .q ndA tsuj ues hatt q to iptmluly htwi teh /13 yuo gto irreeal. hTe q evlau stlle uoy het elllea ecyrunqef in het pa,uponolti rhwheet eht osrpne is a raeicrr ro uomgsoohyz verecssie b.oth uoY lilts ogt t,i ubt usjt tenltig ouy nwko het resaie route in easc oyu ees ti ngi!aa +2


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 +0  upvote downvote
submitted by kdckjn(0)
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hwy ehrte si blbytpiiaor of htefar enibg a rearicr is 2/3

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drdoom  eW msaues hits is a eessrecvi iseads.e nI ohetr rwdso, yuo iamfstne teh isadsee fi uoy rneihit a iesaeds ,lleale ,d from your tromhe dna a dieesas le,lela ,d rfmo ryou traf,eh ivgngi yuo na lealle gpainir odndete by .dd dd = yuo avhe eth .saisede Teh refath odes tno heav hte iasds;ee htis enmsa hsi oneegtpy acn lyon eb 1 of rethe gstn:ih ,DD D,d ro D.d athT si, DD = D rmfo ihs d,da D rfom shi mom; Dd = D rfom his add, d ofmr ihs om;m ro Dd = d rfmo his da,d D mofr ihs .mmo Noicte hatt ni yoln wto of seeth 3 isiopbiistsel sdoe hte raethf lntoipta)e(ly eahv a siedeas eealll ()d ttah he higtm psas no to ihs oy.pgern +

We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).

dd = you have the disease.

The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.

That is,

  • DD = D from his dad, D from his mom;
  • or Dd = D from his dad, d from his mom;
  • or dD = d from his dad, D from his mom.

Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.

+1/- drdoom(1206)

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