aeMlnidan eGsinet:c
aMn has 23/ canech of bgien a .erriacr e(H dsoe ton ahev hte easesi)d. ona mW iacerrr kisr mstu eb eucctllada twhi ^p2 + p2q + 2q^. ^2q = /,040010 q = /02,10 p is lourgyh = 2 1qp = 1010/ = arrCeir qfueyecnr .
isRk of hvgnai a cihdl hsut lqusae 23/ x 0110/ x 41/ = 160/0s:c3e2/uBe a = nMa rCerria irsk 1/0 01 = mFelea reaCrir 4i 1Rsk/ = hCenca yhte aceh ssap on het rssecivee geen ot itehr gorsffi.pn
hTsi teh msae sa @ksmpenyyo'ac tlonaaepnix hwit meor olatnanpiex esoht that eend i...t
ehT tietpan is daefnctefu by het alrcuatirp oaulamtos sseeircev isaedse dna ihs rohbert sah eth stmuoolaa irsesveec disesea -t&g;- iths manse chae fo ireht eapnstr isacrer hte RA le.llea w,oN fro teh taipten ot eb enadcfftue viegn atth thob sih sprenta ahev the AR llele,a it seanm ttah eht ttpnaei has a /23 acchen ttha eh si euoysusatlmiln enfctaeufd nad a erca.irr
ehT tep'antis rnterpa is tfndcueafe adn oamlrn eHye-idWbrgarn icnetsge (as dttsea ni het p)erl.nhomwb.e ihst si cyicseiflpla ,eeionmtdn you era ot masuse ttah eth trenpar ash a aricrer nerucfqye rfo het RA e,lllae hchwi qelau to p2.q
Teh aiesdse ash a cfureenqy in eth lootuinppa fo 01.040/0 siTh si q2^ g;&--t 2^q = 0010.04/ olivgSn ofr q, oyu tge q = .200/1
rCearri fqrenecuy is .2pq wHorvee, orf a earr ssed,eia q2p ≈ q.2 S,o teh rcerrai nucreqfey ofr eth nertpra = 2q = 2 * 21/00 = 0.1/10
oNw, eht Q assk obatu na osnpfrigf of teh eanptti dan ihs rnraept nibge fecdtaef, os ot evah an tcfeaefd cildh, erhet is a 1/4 ehcnca fo ginvah an etafcfed icldh euscbeas( teh iaetntp adn eth ptraren tohb aehv a 1/2 hccnea of snagspi the lellae ;g-&-t oyu leuplmti sthee teerhtog /12 * ).21/
oS, upyltmil /32 * 0/011 * 4/1 = 1/0.60 hTis is teai(pntP ingeb a erair)cr * te(nraPpr iegbn a rira)ecr * nvPgiah( an effcetad gipnforfs ee)toh.tgr
hTe rtpbibloiay fo hte rfeath giben a riecarr is 23/ ciens it is nkwno hatt he ds’neot ehav teh d.asiees nheT eth ltbbrayoiip fo imh psinasg ti on to shi dik :si
1/2 * 23/ = 1/3
iWht hte d-berrWHigneay rinelPi,pc oyu cna ruifeg tou eth pltrbyaboii fo hte eotmrh negib a ecri:arr
q = trq0001/4(0,)s = 2010/
S,o p2q = 2 * 2/100 * 01920/9, ihhcw xpoarp si 1100,/ nad hte piolbabrtyi fo het dclih ggietnt ihts ellela is 1001/ * 1/2 = 21/00
:Tshu
0120/ * 3/1 = 010/6
wyh hrtee is arbpobiyilt fo tarfhe ginbe a rcaierr si 2/3
We assume this is a recessive disease. In other words, you manifest the disease if you inherit a disease allele, d, from your mother and a disease allele, d, from your father (giving you the allele pairing denoted by “dd ”).
dd = you have the disease.
The father does not have the disease; this means his genotype cannot be dd and thus must be one of 3 things: DD, Dd, or dD.
That is,
Notice that in only two of these 3 possibilities (⅔) does the father (potentially) have a disease allele, d, that he might pass on to his progeny.
submitted by ∗drdoom(1206)
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$279$49latnuociCals for dad. ehT pliybrbtaio fo the earthf eigbn a crreari si 3/2 esicn ti si nnwko that he ond’ets ehva eth eiaes.ds nehT eht babpoiitylr of him spsagin it no to ish idk is 1,2/ hust:
lsoaCtanlcui rof omm. ithW the r-WybgedeiHnra lirnce,Pip yuo cna rgieuf otu eth ltaipbrioyb of the mrhote nbeig a i:craerr
q = sr01,4)0(0tq/0 = /2010S,o
2qp = 2 * /0102 * 01299/0, whhic si oxappr /0.110oFr hte hdlic ot egt het elella fmro mm,o tow gshnti dnee to :npeaph ()1 omm smut be a eicarrr etr”yze“ego]to[h nad )(2 omm umst ssap teh eallel ot d:hicl
nuPgti it all hgreetto. ,owN bmenico lla ete:ogthr
= byaripi(oltb fo dad igbne )cairrre * iptlbaybrio( fo dda agspsin on esseaid all)lee * o(ltarpiibyb fo mom begni rirera)c * ybbpaoiri(tl fo mom pgsnsai on edssiea e)allel
=
2/3 * /21 * /1100 * 2/1=
1 ni 006$279$49