NBME Answers : abkapoor's page

Subcomments ...

submitted by cassdawg(1781), visit this page

get full access to all content ⋅ become a member

This is Neurofibromatosis Type I, which is an autosomal dominant disease (FA2020 p60, 525)

Even if you did not know this fact, you could likely guess autosomal dominant based on the inheritance pattern and general disease described. It is VERY COMMON in the family on one side (the mothers) and it did not skip a generation. Autosomal recessive skips generations. Mitochondrial with variable penetrance could be possible, but the disease pattern for mitochondrial are myopathies, metabolic, or optic neuropathy. X-linked would have ALL of the sons of the mother affected (whether it was dominant or recessive).

get full access to all content ⋅ become a member

abkapoor X-linked dominant may not have all of the sons of the mother affected if she gives her other x chromosome (unaffected chromosome). It is technically possible for this disease to follow x-linked dominant inheritance. The question just requires you to assume this is NF1 +4

jdc_md if it was X-dominant not all of the sons would have it because the mom could/would most likely be Xx genotype. If the inheritance was x-recessive and the mother possessed the phenotype then all of the sons would be affected +

abkapoor Its theoretically possible for it to be X-linked dominant. Its just unlikely. +

submitted by tea-cats-biscuits(273), visit this page

get full access to all content ⋅ become a member

Fibronectin is an extracellular matrix glycoprotein, while lamin is an intermediate filament that specifically provides support to the cell nucleus. Don’t confuse lamin with laminin (science hates us clearly); laminin is like fibronectin, an ECM glycoprotein and a major component of the basal lamina of basement membranes.

get full access to all content ⋅ become a member

masonkingcobra Lamin looks like a "cross" and held up Jesus and the basal lamina is super important just like jesus (you bet there are people who believe this) https://answersingenesis.org/biology/microbiology/laminin-and-the-cross/ +45

dr.xx blasphemy @masonkingcobra +1

luciana I clearly confused lamin with laminin, now I know +3

almondbreeze FA 2019 pg 48 lamin +1

almondbreeze picked tubulin but i guess tubulin makes up microtubules and therefore is spherical +

abkapoor Also remember progeria is due to lamin a dysfunction, and progeria patients have messed up nuclei +

brise @abkapoor the f is progeria? and do we need to know it for step? +

brise @abkapoor omg jk jk wow +

submitted by drachenx(72), visit this page

get full access to all content ⋅ become a member

These kinds of questions are really hard because I've never seen female reproductive structures irl. :c

get full access to all content ⋅ become a member

nbmehelp Lmao +3

regularstudent Lmao +1

mutteringly Lmao +

rockodude lmao +

abkapoor Lmao +

dang90 LMao +

noopnoop Lmfao +

stunna216 LMAO +

icrieeverytiem lmao +

peteralamir Lmaoo +

empem28 lmao +

submitted by medstruggle(21), visit this page

get full access to all content ⋅ become a member

Why is it not ovarian follicle cells? I thought the female analog of Sertoli and Leydig is theca/granulosa cells.

get full access to all content ⋅ become a member

colonelred_ Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen. +16

brethren_md Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen +5

sympathetikey Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen +6

s1q3t3 Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen +13

masonkingcobra Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen +4

mcl Wait, but did anyone mention that females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen??? +42

mcl But seriously though, pathology outlines says sertoli-leydig tumor "may be suspected clinically in a young patient presenting with a combination of virilization, elevated testosterone levels and ovarian / pelvic mass on imaging studies." As for follicle cell tumors, granulosa cell tumors usually occur in adults and would cause elevated levels of estrogens. Theca cell tumor would also primarily produce estrogens. Putting the links at the end since idk if they're gonna turn out right lol Link pathology outlines for sertoli leydig granulosa cell tumor theca cell tumor +13

bigjimbo LOL +1

fallenistand Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen. +6

medpsychosis So after doing some intense research, UPtoDate, PubMed, an intense literature review on the topic I have come to the final conclusion that...... ...... ...... ...... Wait for it.... ..... ..... Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen. +10

charcot_bouchard Hello, i just want to add that Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen +2

giggidy Hold up, so I'm confused - I read all the posts above but I still am unsure - are sertoli-leydig cells notorious for producing androgen? +6

subclaviansteele Hold the phone.....Females can get sertoli leydig cell tumors which are notorious for producing androgen? TIL TL;DR - Females can get sertoli leydig cell tumors = high androgens +1

cinnapie I just found a recent study on PubMed saying "Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen" +3

youssefa Hahahahaha ya'll just bored +11

water Bored? you wouldn't think so if you knew that females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen +6

nbmehelp I dont get it +1

redvelvet how don't you get it that females can get Sertoli Leydig cell tumors, which are notorious for producing lots of androgen? +2

drmomo what if this means..... females can get Sertoli Leydig cell tumors, which are notorious for producing lots of androgen +1

sunshinesweetheart hahahaha this made my day #futurephysicians #lowkeyidiots +1

sunshinesweetheart @medstruggle look up placental aromatase deficiency (p. 625 FA 2019), it would have a different presentation +1

deathbystep1 i am sure i would ace STEP 1 if i only knew that females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen +3

noplanb Wait... I might actually never forget this now lol +4

drmohandes Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen. +2

lilmonkey Don't forget that females can get Sertoli-Leydig cell tumors, which are notorious for producing lots of androgens! You're welcome! +1

drpatinoire Now I get it that females can get Sertoli-Leydig cell tumors, which are notorious for producing lots of androgens. Thank you very much.. So why choose Sertoli-Leydig cell tumor again? +1

dr_ligma The reason is because females can get Sertoli-Leydig cell tumors, which are notorious for producing lots of androgens! This is easy to remember, as you can remember it through the simple mnemonic "FCGSLCTWANFPLOA" which stands for "Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen!" +22

minion7 after receiving a f*king score..... this post made me smile and thanks to the statement-- females can get sertoli-leydig cell tumours, which are notorious for producing lots of androgen! +2

djtallahassee My worthless self put adrenal zona fasciculate but now I will never forget that females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen +2

medguru2295 Wait..... so can females get Sertoli Leydig cells that produce androgens then?????? +1

peqmd Going to snapshot this to my anki deck card: "females can get Sertoli-Leydig cell tumors, which are notorious for producing lots of {{c1::androgens}}" +2

paperbackwriter Watch me f*ck up the fact that females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgens on the real deal. +3

alexxxx30 just made sure to add to my notes "Females can get sertoli leydig cell tumors, which are notorious for producing lots of androgens" +3

peridot I also just wanna add that if you look on in FA on p.696969, you'll see that they'll mention "Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen" +2

mbate4 According to the literature [lol] females can get sertoli-leydig cell tumors, which are notorious for producing lots of antigens +1

drdoom the tradition lives on +2

jamaicabliz Wait... so for clarification, is it that females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen? Or that Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen?? HELP +1

abkapoor Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgen sorry for bad Englesh +1

faus305 Sertoli-leydig cells are notorious for producing lots of androgens, females can get these. +1

djeffs1 the fact that a bunch of medstudents can get so weird about how females can get sertoli-leydig cell tumors: notorious for producing lots of androgens- just made my week!! I love you guys +1

niftykoala As an extra piece of information, I would like to add that Bungee Gum possesses the properties of both rubber and gum. +

neurotic999 Oh I get it! Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgens. Makes alot more sense now after reading it a hundred times. Thanks guys! +

rdk3434 okay , this actually made my day and i also learned that Females can get sertoli-leydig cell tumors, which are notorious for producing lots of androgens!!productive +

laravonter Since it has been a month, I feel the need to remind all that sertoli-leydig cell tumors are notorious for producing lots of androgens +

thisisnewgg FCGSLCTWANFPLOA +

submitted by cassdawg(1781), visit this page

get full access to all content ⋅ become a member

This is Neurofibromatosis Type I, which is an autosomal dominant disease (FA2020 p60, 525)

get full access to all content ⋅ become a member

abkapoor Its theoretically possible for it to be X-linked dominant. Its just unlikely. +