NBME 24 Intestinal mucosa (NBME Answers)

NBME 24 Answers

nbme24/Block 2/Question#48 (reveal difficulty score)
The breakdown of dipeptides and tripeptides ...
Intestinal mucosa 🔍 / 📺 / 🌳 / 📖
tags: GI

+381 upvote downvote
submitted by ∗seagull(1933)

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heT tcseasmin fo siht steinouq dmae em itomv ld.oob

neO dya a aenpitt lliw kolo me in teh eesy dan s,ka hree"W aer tidpesetri onbkre ?w"ond I liwl meils ta mhte nad asy, hte" tstneilian smaouc dan ton hte od"uemndu. eThl'ly mlsie ckab and 'Ill aklw yawa dan ihntk of thsi nmeotm as I jupm rfmo eht owniw.d

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sympathetikey Too real. +5

mcl how do i upvote multiple times +22

trichotillomaniac I made an account solely so I could upvote this. +40

dragon3 ty for the chuckle +8

cinnapie @trichotillomaniac Same +5

thedeadly96 XD made my day! +2

hardly43 RIP legend @seagull +2

seagull A legend never die +4

+56 upvote downvote
submitted by ∗drdoom(1205)

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eTh aunedldo mlnue an(d ricaetapcn epeastosr kile OSNPTIYYRC)HM si eht teis wrehe ctpcneiaar zyemesn eess”tdo“ep)(npaid leaevc legar tpdoplysepei itno rmlslae bist rtp=ep)ptsist,(i.depiddiee It is at eht RBHSU OERBDR weerh hte selmslat nkdis fo pspetdie ,rie)iieit(sptppeedpstdd ear oknebr donw iton hetri moain dias,c iwchh lnyailf cna be ersortao-ctdpn with N+a noit hte istiatnlne .llce

I inhtk buato it siht yw:a

hostacm adci erntaesdu dan spen“o p”u esiptnro hw(ioutt pesificc )el;aecvag
iactpecarn ezmysen thne eavlec dneatedur tsepoypilpde otni asellrm ibts;
rbsuh errbod ymensez iyllfna abrek nwod sineitt deiesptp noit saalebrbbo namoi .scdia

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regularstudent Isn't the brush border still part of the intestinal lumen? Don't the amino acids enter into the intestinal cell (the "intestinal mucosa")? +1

drdoom @regularstudent No, the lumen is literally the cavity—the empty space. +2

jj375 Still annoyed about this question, but here is a schematic in case it helps anyone else: https://doctorlib.info/physiology/medical/medical.files/image1890.jpg +2

drdoom @jj375 best schematic i’ve seen so far. superb. +2

+4 upvote downvote
submitted by ∗am4140(8)

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One of hte sDoorct ni grnTiani deoivs elakdt batou otniaospbr fo nenutsr,ti dna cafiiellypcs ietemnond that tidiepsdpe adn dpreitseitp are roctpsteonrad thiw orydehng noti the ienntIstla lmucaso lscel lwihe sinelg AAs aer odnparseotctr iwht N.a+ So otn olny od edieitpdps nad epdriietpst ekma ti onti hte ianlsittne mosuca rbeofe giben rkbone wond, hety ytluclaa etg in rsfaet anht inlgse AsA .do

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weirdmed51 Kudos! To you +1

+2 upvote downvote
submitted by ∗nerdstewiegriffin(45)

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M:e I am osryr ot ays ubt ueebcas fo eht enucnoseseqc fo oyru DM we ilwl vhea to tptaaume royu ge:iPttlnea ya,ko but I vaeh noe eitsoqnu eM: ePti: sneta?y si foseucrt rekbno dnow in titaelnsni eumnl or nstlneiiat ec:s? Muamo :.tP.. te.ani. . .e..M.: I ihknt tis itainetnsl ulnme

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+1 upvote downvote
submitted by ∗weirdmed51(30)

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Tsih unetsiqo robek me omer nhta het tisdepep.

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+1 upvote downvote
submitted by ∗medstruggle(20)

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Wyh si ldandoue unmle eicn?otrrc I ogtthuh inaatrpcce senzeym cpr,tmisonhy(y odyera)ipbtcsxepa luowd be dceoatl e.her

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colonelred_ Enterokinase actives trypsinogen and is located closer to the intestinal mucosal (“brush border”). +2

drdoom Yeah, @colonelred is right. @medstruggle: the duodenal lumen (and the pancreatic /proteases/ you mention) is the site where pancreatic enzymes (“endopeptidases”) cleave large polypeptides into smaller bits. It is at the BRUSH BORDER where the smallest kinds of peptides (dipeptides, tripeptides) are broken down into their amino acids, which finally can be co-transported with Na+ into the intestinal cell. I think about it this way: stomach acid denatures and “opens up” proteins (without any specific cleavage); pancreatic enzymes then cleave denatured polypeptides into smaller bits; brush border enzymes finally break down tiny peptides into absorbable amino acids. +4

welpdedelp http://1.bp.blogspot.com/-UDdBiBiEgec/UzM61mV4pTI/AAAAAAAABRA/_qCG05fliGk/s1600/VBN.PNG +35

drdoom Nice schematic, @welpdedelp +1

drdoom ^ linkifying @welpdedelp http://1.bp.blogspot.com/-UDdBiBiEgec/UzM61mV4pTI/AAAAAAAABRA/_qCG05fliGk/s1600/VBN.PNG +4

asmamohammadi https://www.youtube.com/watch?v=HL7-fYBtJ1Y +1

+0 upvote downvote
submitted by xs34_23(0)

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rsehet a nazik acrd ni eht IG dkec romf cozsoatn nosgiwh uilnmal sedi p/Hiitep+edd nad pHrte+e/iidtp cpetosrstr.a-onr hnTe indsie eht eittsnlain am,oucs teh di nda epsrtptieid era kberno dwon oint aomin dscia hrwee a aabsl sdie ornetrrtpas tups tmhe ntoi teh obodl etrsma

reHes a nlik ihgowsn ah:tt

6vlpYw4gzwJIeCwxrEyQSQZElw71NClKhRs7mbRr4.ox1soE/cVhzDj6y/rE1Y_.U-3tlyop_ewWxolTRJmLGi06TuybZ/NHnlmputnEJ6BcoeoUN/3Luc4ARsbxeALrJtAzK:YctKb306d6rgn-_ooDsjtgnibgDNyg

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+0 upvote downvote
submitted by ∗jbrito718(48)

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i-D dan r-iT peipsted cna tnree tnoi cneetyserto vai Tep1P toreprsatrns dna eb broekn dwon ot aionm idcas hnwtii the ectore.stnye neHce wyh het nlume si tno eth tbes esanrw

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-1 upvote downvote
submitted by ∗seagull(1933)

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ehT cisstnema fo isth stuqinoe dema me vmiot o.dobl

At talse eon ayd a niatetp wlil okol me ni eht ysee and aks " rheew rae dptterseii rnobke onwd .ta" I will smeli ta mhte adn sya t"he taenilnsit smcuao nad tno het mdu.eo"nud T'leyhl ielms ckba dna thne l'il nhet i'll alkw awya nda nkith of siht etmnom sa I pumj fmro eht d.oiwnw

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weirdmed51 You got 331 vote for this dear, need more? +1

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