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NBME 24 Answers

nbme24/Block 2/Question#5 (43.4 difficulty score)
A 55-year-old man is diagnosed with coronary ...
Decreased adherenceπŸ”

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submitted by lamhtu(113),
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aetlPtle draeehnce nad pateellt aoggtrgeain are rinffeedt stnigh nda tihs rnfereiecd MSTTREA A .OTL uckF yo,u BMNE. seTeh ceidenffres ppsyuesdlo ramett on some iqtsenuso dan ton on rtsho.e ehWer si hte ntnc?seoscyi ?lelHo

hungrybox  Agreed. This is so fucking stupid. +  
hungrybox  "Aspirin inhibits platelet aggregation and produces a mild bleeding defect by inhibiting cyclooxygenase, a platelet enzyme that is required for TXA2 synthesis." literally straight from Big Robbins +1  
susyars  Im gonna upvote this bc i love to be right +5  
regularstudent  It's always a horrible, horrible feeling to pick the wrong answer that you know they think is right. Amazing job NBME... +4  
j44n  yeah i thought adherence was the GP1B receptor that's already on the platelet +1  
j44n  im also glad we're getting exposed to this horse shit now and now when I'm in a testing center about to put my fist through a screen. +1  
jurrutia  GPiib/iiia receptor is not inhibited by aspirin. Aspirin prevents the upregulation of GPiib/iiia which is not the same as inhibiting the receptor itself. +  

submitted by susyars(29),

Im gonna fight this one because AGGREGATION is mediated by expression of Gp IIb/IIIa.

If your platelet increases TXA2 that means is gonna upregulate AGGREGATION by which receptor? ... Duh

Once Im done with this test and become a Pathologist Im gonna send you a copy of my journal and research on platelet aggregation mediated by TXA2 and Gp IIb/IIIa and also im gonna go over every single WTF NBME question and prove them so wrong

Maybe i should change my username before submitting this

corgilobacter  Dr. Tio Goljan Jr. In the house everyone. CLAPS +  
susyars  Tio Goljan would be so proud of me +  
j44n  I agree TXA2 up-regulates the GP2b3A receptor that mediates aggregation. +  

submitted by step1forthewin(2),
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aCn emonoes aeelsp laicyfr eth ewasrn. sI adedcerse aeedrcenh msea as aecdsedre otgggnre?iaa uWtl;don ioinitnihb fo hte Ib/IaIII torrepec vrnetpe i?aroagentgg

xxabi  I'm not completely sure...but I think its because its aspirin, and aspirin doesn't work on IIb/IIIa receptors. That's why i picked decreased adherence of platelets, figured that was the closest thing to decreased aggregation that still made sense with aspirin's mechanism of action. Hope that helps! +2  
ihavenolife  Aspirin irreversibly inhibits COX which leads to decreased TXA2. TXA2 normally is a vasoconstrictor and induces platelet aggregation, so aspirin inhibits platelet aggregation by downplaying TXA2 not by interacting with IIb/IIIa receptor. (Source FA and UWorld) +21  
fallenistand  In this case, inhibition of COX-1 by aspirin will also reduce the amount of precursors for vascular prostacyclin synthesis, provided, for example, from adhering platelets +1  
niboonsh  inhibition of IIb/IIIa receptor is the moa of a completely separate class of drugs - Glycoprotein IIb/IIIa (abciximab, eptifabide, tirofiban) +1  
t123  Bad question - TXA2 upregulates GpIIb/IIIa on platelets. So aspirin inhibits their expression. +1  

submitted by xw1984(4),

English is not my first language, but would it be possible that adherence is not equivalent to adhesion and somehow interchangeable to aggregation? I feel like doing a reading comprehension test, not USMLE.

submitted by thisshouldbefree(26),

TXA2 doesnt seem to mediate induction of GP2b/3a. fa19/pg403 - ADP binding to P2Y12R induces Gp2b/3a expression at surface. ADP is released from plts. One must think about the down stream functions. If TXA2 helps aggregation via decreasing blood flow. if we therefore dont decrease blood flow we cant get the plts to later adhere properly.

submitted by tiredofstudying(48),

Inhibition of GpIIb/IIIa receptors would be the mechanism of either (FA 2020 411):

Clopidogrel, prasugrel or ticlopidine via inhibition of ADP-induction of GpIIb/IIIa by blocking P2Y12


Abciximab, eptifibatide, and tirofiban by direct GpIIb/IIIa inhibition.

A lot of questions will have very similar answer choices on the real exam, but there will always be one best answer, and decreased platelet adherence was the better answer here. As stated on many other question threads, there are plenty of tricky questions to be upset about, but this was not one of them.

woodmeister  That's not what's upsetting. What's upsetting is that there is NO correct answer available. You have to put yourself into the head of whatever twit wrote this question and try to guess how much they care about the fact that aggregation (GPIIB/IIIA + TXA2 mediated) and adherence (GPIB mediated) are not the same thing. +1