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NBME 21 Answers

nbme21/Block 4/Question#45 (60.6 difficulty score)
During an experiment, an investigator ...
NMDA receptors are blocked by Mg2+ at the resting membrane potential🔍
tags: neuro magnesium pharm 

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 +42 
submitted by niboonsh(299),
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vs:twH.ohy/u?.cw/ptaDwu/-tcum=h2owob4vweQtz fi ur ylza klie me, tshi si a dogo ehefrrres eivod

d_holles  Amazing video dude. Somehow never learned this in neuro lol. +5  
aag  Awesome video! Is this why you can give Mg2+ to eclampsia patients, because if so, mind goddamn blown. +1  



 +3 
submitted by sweetmed(129),
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tA tngeirs raembemn plienaott het MNAD csepretor ear obeckld yb M2g.+ eTh eagltov depntdeen M2g+ lbokc si deeierlv upon tpoieizlarando of hte p-aotnssytcip mrmneabe . heT danlig edpeetndn atintovaic of het NDMA rceotepr ursieerq -iatcicaovont by wto sandgl,i lnemya teatmglua adn .lgnceyi




 +3 
submitted by cantaloupe5(69),
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hisT eno was kritcy utb I itnkh you e’vlocud dnoe ihst eon uwtohti gdwneleok fo MNDA ecosp.terr Smte lodt yuo tath atmateglu etavctasi ohtb DNnMAo-n dan NDAM eprrtecso tub it vatcitaed lyno N-MoADnn roetpescr in teh lerya hap.es That mnesa DMNA toerecspr teaaivtc fetra -NonnADM cteprros.e thaT maens otmehsgin aws yliadgen NDAM ertoeprc nigavcatti and het oynl nrawse taht mead ensse sa eht gM bighniiitn MDAN ta ginerst patn.tlieo ncOe eth lecl is iepdrzolead by -NnAMoDn srte,poerc MDAN eertcprso nca eb tvideta.ac

hungrybox  I forgot/didn't know this factoid and narrowed it to the correct answer and a wrong answer. Guess which one I chose? +11  
yotsubato  >That means something was delaying NMDA receptor activating and the only answer that made sense as the Mg inhibiting NMDA at resting potential. What makes the fasting gating kinetics choice incorrect then? +5  
imgdoc  NMDA receptors are both voltage gated and ligand gated channels. Glutamate and aspartate are endogenous ligands for this receptor. Binding of one of the ligands is required to open the channel thus it exhibits characteristics of a ligand channel. If Em (membrane potential) is more negative than -70 mV, binding of the ligand does NOT open the channel (Mg2+ block on the NMDA receptor). IF Em is less negative than -70 mV binding of the ligand opens the channel (even though no Mg2+ block at this Em, channel will not open without ligand binding. Out of the answer choices only NMDA receptors blocked by Mg2+ makes sense. Hope this helps. +6  
divya  sweet explanation imgdoc +  
lovebug  really~~~ sweet. thankyou :) +  



 -1 
submitted by vlodkadrinker(6),
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'dnot frogte tboau the gM c!olbk . . . . . .