The picture shown in the question is a classical description of a mild compression fracture seen in osteoporosis (see pp462 in FA2020). IL-1 is also known as an osteoclast activating factor and leads to an increase in RANK- ligand (RANK-L) signaling and subsequent osteoclast-mediated bone resorption. Recall that this can be treated by denosumab (a monoclonal antibody against RANKL).
Why couldn't this be multiple myeloma, they look fairly similar and the patient had a long illness, leading me to multiple myeloma. I see how its osteoporosis, but how would you distinguish the two.
submitted by โshak360(19)
Important cytokines
The picture shown in the question is a classical description of a mild compression fracture seen in osteoporosis (see pp462 in FA2020). IL-1 is also known as an osteoclast activating factor and leads to an increase in RANK- ligand (RANK-L) signaling and subsequent osteoclast-mediated bone resorption. Recall that this can be treated by denosumab (a monoclonal antibody against RANKL).