NBME 25 Interstitial adenosine concentration (NBME Answers)

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submitted by ∗shak360(23)

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The local metabolites that vasodilate and increase perfusion to skeletal muscle while exercising are CHALK:

CO2
H+ (Hydrogen ions)
ADENOSINE
Lactate
K+ (Potassium ions)

During rest, the sympathetic tone in arteries (alpha and beta receptors).

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shak360 Another way to think about this question is to recall the fact that adenosine primarily causes coronary dilation which is mediated by A2 receptors (the dilated coronary crown in the DJ Foxglove sketch). See this question in NBME 18. +